Myocardial Ischemia Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles. (Human Disease Ontology, DOID_3393)
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Genes

114 genes associated with the Myocardial Ischemia phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACE angiotensin I converting enzyme
ADD1 adducin 1 (alpha)
ADORA1 adenosine A1 receptor
ADORA3 adenosine A3 receptor
ADRA1A adrenoceptor alpha 1A
ADRA2A adrenoceptor alpha 2A
ADRA2B adrenoceptor alpha 2B
ADRA2C adrenoceptor alpha 2C
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AMPD1 adenosine monophosphate deaminase 1
APOA1 apolipoprotein A-I
APOB apolipoprotein B
APOC3 apolipoprotein C-III
APOE apolipoprotein E
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
CBS cystathionine-beta-synthase
CCL2 chemokine (C-C motif) ligand 2
CD14 CD14 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CETP cholesteryl ester transfer protein, plasma
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
COL3A1 collagen, type III, alpha 1
COMT catechol-O-methyltransferase
CRP C-reactive protein, pentraxin-related
CYBA cytochrome b-245, alpha polypeptide
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DRP2 dystrophin related protein 2
EDN1 endothelin 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHX2 epoxide hydrolase 2, cytoplasmic
ESR1 estrogen receptor 1
F13A1 coagulation factor XIII, A1 polypeptide
F2 coagulation factor II (thrombin)
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FGB fibrinogen beta chain
FLG filaggrin
GCKR glucokinase (hexokinase 4) regulator
GHRL ghrelin/obestatin prepropeptide
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GP1BA glycoprotein Ib (platelet), alpha polypeptide
HBB hemoglobin, beta
HFE hemochromatosis
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMOX1 heme oxygenase 1
HRES1 HTLV-1 related endogenous sequence
IL10 interleukin 10
IL4 interleukin 4
IL6 interleukin 6
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KIF6 kinesin family member 6
LCAT lecithin-cholesterol acyltransferase
LDLR low density lipoprotein receptor
LIPC lipase, hepatic
LPA lipoprotein, Lp(a)
LPL lipoprotein lipase
LTC4S leukotriene C4 synthase
MBL2 mannose-binding lectin (protein C) 2, soluble
MEF2A myocyte enhancer factor 2A
MOK MOK protein kinase
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MTTP microsomal triglyceride transfer protein
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NR1H3 nuclear receptor subfamily 1, group H, member 3
PCSK9 proprotein convertase subtilisin/kexin type 9
PDE4D phosphodiesterase 4D, cAMP-specific
PON1 paraoxonase 1
PON2 paraoxonase 2
PPARA peroxisome proliferator-activated receptor alpha
RNLS renalase, FAD-dependent amine oxidase
SCN5A sodium channel, voltage gated, type V alpha subunit
SELPLG selectin P ligand
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
TGFB1 transforming growth factor, beta 1
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TRIB1 tribbles pseudokinase 1
TRNL
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
VEGFA vascular endothelial growth factor A
ZNF202 zinc finger protein 202