Myelodysplastic Syndromes Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

166 genes associated with the Myelodysplastic Syndromes phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ASXL1 additional sex combs like transcriptional regulator 1
AURKA aurora kinase A
BCOR BCL6 corepressor
BCORL1 BCL6 corepressor-like 1
BMX BMX non-receptor tyrosine kinase
BTK Bruton agammaglobulinemia tyrosine kinase
C5ORF66-AS2 C5orf66 antisense RNA 2
CALR calreticulin
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
COX1
COX2
CSF1R colony stimulating factor 1 receptor
CSF3R colony stimulating factor 3 receptor (granulocyte)
CSK c-src tyrosine kinase
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DNAJC18 DnaJ (Hsp40) homolog, subfamily C, member 18
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
ECSCR endothelial cell surface expressed chemotaxis and apoptosis regulator
EED embryonic ectoderm development
EPO erythropoietin
EPOR erythropoietin receptor
ERCC2 excision repair cross-complementation group 2
ETV6 ets variant 6
EYA2 EYA transcriptional coactivator and phosphatase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FES FES proto-oncogene, tyrosine kinase
FLT3 fms-related tyrosine kinase 3
FTMT ferritin mitochondrial
GPX3 glutathione peroxidase 3
GSTA1 glutathione S-transferase alpha 1
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HAMP hepcidin antimicrobial peptide
HAX1 HCLS1 associated protein X-1
HFE hemochromatosis
HFE2 hemochromatosis type 2 (juvenile)
HINT1 histidine triad nucleotide binding protein 1
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HNRNPA1P13 heterogeneous nuclear ribonucleoprotein A1 pseudogene 13
HPSE heparanase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFNG interferon, gamma
IL10 interleukin 10
IL12A interleukin 12A
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
IL6R interleukin 6 receptor
IRF1 interferon regulatory factor 1
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KIR2DL5B killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5B
KIR2DP1 killer cell immunoglobulin-like receptor, two domains, pseudogene 1
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KIR2DS2 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
KIR2DS3 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
KIR2DS5 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
KIR3DP1 killer cell immunoglobulin-like receptor, three domains, pseudogene 1
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
KMT2A lysine (K)-specific methyltransferase 2A
KRAS Kirsten rat sarcoma viral oncogene homolog
LIG1 ligase I, DNA, ATP-dependent
LOC100128966 uncharacterized LOC100128966
LOC100130172 uncharacterized LOC100130172
LOC100131361
LOC389332 uncharacterized LOC389332
LOC391834 ankyrin repeat domain 49 pseudogene
LOC642262 nuclear receptor coactivator 4 pseudogene
LRRTM2 leucine rich repeat transmembrane neuronal 2
LTA lymphotoxin alpha
MATR3 matrin 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEFV Mediterranean fever
MGMT O-6-methylguanine-DNA methyltransferase
MIR221 microRNA 221
MIR222 microRNA 222
MIR874 microRNA 874
MPL MPL proto-oncogene, thrombopoietin receptor
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MT-ND5 NADH dehydrogenase, subunit 5 (complex I)
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
ND1
NF1 neurofibromin 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
OGG1 8-oxoguanine DNA glycosylase
PAIP2 poly(A) binding protein interacting protein 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLK2 polo-like kinase 2
POGLUT1 protein O-glucosyltransferase 1
PROB1 proline-rich basic protein 1
PRPF8 pre-mRNA processing factor 8
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAD51 RAD51 recombinase
RAD52 RAD52 homolog (S. cerevisiae)
RAET1L retinoic acid early transcript 1L
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBBP4 retinoblastoma binding protein 4
RMI1 RecQ mediated genome instability 1
RNR2 RNA, ribosomal cluster 2
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
RPL10AP10 ribosomal protein L10a pseudogene 10
RUNX1 runt-related transcription factor 1
SETBP1 SET binding protein 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SNHG4 small nucleolar RNA host gene 4
SNORA74A small nucleolar RNA, H/ACA box 74A
SNORD63 small nucleolar RNA, C/D box 63
SPATA24 spermatogenesis associated 24
SRSF2 serine/arginine-rich splicing factor 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STYK1 serine/threonine/tyrosine kinase 1
SUZ12 SUZ12 polycomb repressive complex 2 subunit
SYK spleen tyrosine kinase
TET2 tet methylcytosine dioxygenase 2
TGFB1 transforming growth factor, beta 1
TMEM173 transmembrane protein 173
TNF tumor necrosis factor
TP53 tumor protein p53
TRPC7 transient receptor potential cation channel, subfamily C, member 7
TTF1 transcription termination factor, RNA polymerase I
TYK2 tyrosine kinase 2
TYMS thymidylate synthetase
U2AF1 U2 small nuclear RNA auxiliary factor 1
UBE2D2 ubiquitin-conjugating enzyme E2D 2
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WT1 Wilms tumor 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2