Musculoskeletal Diseases Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D009140
Similar Terms
Downloads & Tools

Genes

280 genes/proteins associated with the disease Musculoskeletal Diseases from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
BCAT1 branched chain amino-acid transaminase 1, cytosolic 1.69763
LMCD1 LIM and cysteine-rich domains 1 1.57971
FHL1 four and a half LIM domains 1 1.54596
TGFB2 transforming growth factor, beta 2 1.53627
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.49482
FABP3 fatty acid binding protein 3, muscle and heart 1.4889
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1.48068
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.45484
CLU clusterin 1.45115
MCL1 myeloid cell leukemia 1 1.44599
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 1.44409
TNF tumor necrosis factor 1.42074
TGM2 transglutaminase 2 1.40732
RND1 Rho family GTPase 1 1.4026
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.37958
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 1.37619
CTSB cathepsin B 1.37504
SPP1 secreted phosphoprotein 1 1.36619
CD44 CD44 molecule (Indian blood group) 1.36591
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.34694
HSPA2 heat shock 70kDa protein 2 1.34606
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 1.32577
TUFM Tu translation elongation factor, mitochondrial 1.32577
HEXA hexosaminidase A (alpha polypeptide) 1.32577
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 1.31716
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 1.31716
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.31566
FAS Fas cell surface death receptor 1.31506
SMAD2 SMAD family member 2 1.31327
ARF4 ADP-ribosylation factor 4 1.31297
BAX BCL2-associated X protein 1.31
HOPX HOP homeobox 1.30881
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 1.30881
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 1.3039
JUN jun proto-oncogene 1.29875
ABHD2 abhydrolase domain containing 2 1.29317
PPARA peroxisome proliferator-activated receptor alpha 1.29133
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.28734
CTSL cathepsin L 1.2861
TPM1 tropomyosin 1 (alpha) 1.28425
EGFR epidermal growth factor receptor 1.28119
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 1.27875
CALR calreticulin 1.26607
MTSS1 metastasis suppressor 1 1.26514
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.26205
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 1.26175
DCTN5 dynactin 5 (p25) 1.25557
ZFP36L2 ZFP36 ring finger protein-like 2 1.25557
CYBA cytochrome b-245, alpha polypeptide 1.254
ASPH aspartate beta-hydroxylase 1.25245
IGFBP7 insulin-like growth factor binding protein 7 1.24966
FOS FBJ murine osteosarcoma viral oncogene homolog 1.24843
CCL2 chemokine (C-C motif) ligand 2 1.24244
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.24213
SRM spermidine synthase 1.24056
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 1.23743
CSK c-src tyrosine kinase 1.23488
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 1.23456
GPX3 glutathione peroxidase 3 1.2336
HSPA1B heat shock 70kDa protein 1B 1.23233
PVR poliovirus receptor 1.23201
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.23201
ADD3 adducin 3 (gamma) 1.22916
GEM GTP binding protein overexpressed in skeletal muscle 1.22916
SOCS3 suppressor of cytokine signaling 3 1.22821
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.22696
CRYAB crystallin, alpha B 1.22404
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 1.22371
IL6 interleukin 6 1.22209
TIMP1 TIMP metallopeptidase inhibitor 1 1.22048
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.21855
SLC44A2 solute carrier family 44 (choline transporter), member 2 1.21695
LCN2 lipocalin 2 1.21599
MAPT microtubule-associated protein tau 1.21468
TUBB6 tubulin, beta 6 class V 1.21304
VCAN versican 1.20558
CTSD cathepsin D 1.20196
IRF7 interferon regulatory factor 7 1.19802
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 1.19542
VCAM1 vascular cell adhesion molecule 1 1.19312
DHRS3 dehydrogenase/reductase (SDR family) member 3 1.19312
RBP4 retinol binding protein 4, plasma 1.19312
FKBP4 FK506 binding protein 4, 59kDa 1.1908
UBC ubiquitin C 1.1862
SOX4 SRY (sex determining region Y)-box 4 1.18587
LIN7B lin-7 homolog B (C. elegans) 1.18489
TUBB tubulin, beta class I 1.18424
NOS2 nitric oxide synthase 2, inducible 1.18391
CYCS cytochrome c, somatic 1.18326
IGFBP3 insulin-like growth factor binding protein 3 1.18026
RXRA retinoid X receptor, alpha 1.17926
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 1.17695
STC2 stanniocalcin 2 1.17497
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 1.17366
AP3M1 adaptor-related protein complex 3, mu 1 subunit 1.17366
EGR1 early growth response 1 1.17168
GPNMB glycoprotein (transmembrane) nmb 1.16866
ARHGAP24 Rho GTPase activating protein 24 1.16833
GNS glucosamine (N-acetyl)-6-sulfatase 1.16833
BUB3 BUB3 mitotic checkpoint protein 1.16833
CUX2 cut-like homeobox 2 1.16833
ABLIM3 actin binding LIM protein family, member 3 1.16302
EDN1 endothelin 1 1.1607
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 1.16001
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 1.1529
UBE2J1 ubiquitin-conjugating enzyme E2, J1 1.1529
ABHD6 abhydrolase domain containing 6 1.1529
TIFA TRAF-interacting protein with forkhead-associated domain 1.1529
GJA1 gap junction protein, alpha 1, 43kDa 1.15022
FNTA farnesyltransferase, CAAX box, alpha 1.1485
RFTN1 raftlin, lipid raft linker 1 1.14816
MEN1 multiple endocrine neoplasia I 1.14816
RNASET2 ribonuclease T2 1.14781
CCNG2 cyclin G2 1.14438
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 1.1437
MTCH2 mitochondrial carrier 2 1.1437
BCL2 B-cell CLL/lymphoma 2 1.14234
ENC1 ectodermal-neural cortex 1 (with BTB domain) 1.14064
ETF1 eukaryotic translation termination factor 1 1.13895
RBM24 RNA binding motif protein 24 1.13862
SRPRB signal recognition particle receptor, B subunit 1.13862
NOS3 nitric oxide synthase 3 (endothelial cell) 1.13724
NEFH neurofilament, heavy polypeptide 1.13689
HDAC1 histone deacetylase 1 1.13655
CKB creatine kinase, brain 1.13655
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.13586
KIF3A kinesin family member 3A 1.13415
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.13313
MGP matrix Gla protein 1.1294
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.12872
IFRD1 interferon-related developmental regulator 1 1.12771
NRP1 neuropilin 1 1.12564
LMNA lamin A/C 1.12391
MAPK8 mitogen-activated protein kinase 8 1.12357
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.12323
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.12048
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 1.11741
UCK2 uridine-cytidine kinase 2 1.11741
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.11639
MMP14 matrix metallopeptidase 14 (membrane-inserted) 1.11571
TAGLN transgelin 1.11396
FLT1 fms-related tyrosine kinase 1 1.11396
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 1.10942
RANGAP1 Ran GTPase activating protein 1 1.10942
FDFT1 farnesyl-diphosphate farnesyltransferase 1 1.10769
MAPK3 mitogen-activated protein kinase 3 1.10665
LBH limb bud and heart development 1.10596
DPP7 dipeptidyl-peptidase 7 1.10562
GADD45G growth arrest and DNA-damage-inducible, gamma 1.10211
MEST mesoderm specific transcript 1.10211
NAV2 neuron navigator 2 1.1014
MAPK1 mitogen-activated protein kinase 1 1.09927
BCL2L1 BCL2-like 1 1.09822
CLIP1 CAP-GLY domain containing linker protein 1 1.09822
ATF3 activating transcription factor 3 1.09822
CSE1L CSE1 chromosome segregation 1-like (yeast) 1.09786
CES2 carboxylesterase 2 1.09786
SOD1 superoxide dismutase 1, soluble 1.09646
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 1.09436
HBEGF heparin-binding EGF-like growth factor 1.09436
PSIP1 PC4 and SFRS1 interacting protein 1 1.09436
TCF3 transcription factor 3 1.09436
RCAN2 regulator of calcineurin 2 1.09401
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.09154
SET SET nuclear proto-oncogene 1.09154
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.09154
ADCY7 adenylate cyclase 7 1.09047
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 1.08975
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.08975
LDHA lactate dehydrogenase A 1.08833
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 1.08833
RGS2 regulator of G-protein signaling 2 1.08833
PRKCDBP protein kinase C, delta binding protein 1.08762
HFE hemochromatosis 1.08726
EMP2 epithelial membrane protein 2 1.0869
GLUL glutamate-ammonia ligase 1.0869
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.0869
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase 1.0869
CACYBP calcyclin binding protein 1.0869
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.08442
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 1.08407
TM7SF2 transmembrane 7 superfamily member 2 1.08407
RIPK2 receptor-interacting serine-threonine kinase 2 1.08372
PCTP phosphatidylcholine transfer protein 1.08337
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 1.08337
THBS1 thrombospondin 1 1.08055
MXI1 MAX interactor 1, dimerization protein 1.08055
ANXA2 annexin A2 1.08055
ABHD4 abhydrolase domain containing 4 1.08019
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 1.08019
SLCO4A1 solute carrier organic anion transporter family, member 4A1 1.07732
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 1.07696
MGEA5 meningioma expressed antigen 5 (hyaluronidase) 1.07696
HTRA2 HtrA serine peptidase 2 1.07696
ANXA5 annexin A5 1.0766
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 1.07376
ELL2 elongation factor, RNA polymerase II, 2 1.07376
SORBS1 sorbin and SH3 domain containing 1 1.07128
CXADR coxsackie virus and adenovirus receptor 1.07057
CCNL1 cyclin L1 1.07022
ACTN1 actinin, alpha 1 1.07022
CYR61 cysteine-rich, angiogenic inducer, 61 1.06808
FZD2 frizzled class receptor 2 1.06771
LAMB1 laminin, beta 1 1.06771
GLDC glycine dehydrogenase (decarboxylating) 1.06698
PEPD peptidase D 1.06698
CCND3 cyclin D3 1.06588
CCNB2 cyclin B2 1.06479
PALLD palladin, cytoskeletal associated protein 1.06406
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 1.0637
STAT2 signal transducer and activator of transcription 2, 113kDa 1.0637
TP53 tumor protein p53 1.06261
BIRC5 baculoviral IAP repeat containing 5 1.06008
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.059
CAT catalase 1.05864
RAMP1 receptor (G protein-coupled) activity modifying protein 1 1.05828
MRPL51 mitochondrial ribosomal protein L51 1.05793
PTPN6 protein tyrosine phosphatase, non-receptor type 6 1.05535
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 1.05461
IFITM1 interferon induced transmembrane protein 1 1.05237
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 1.052
ZBTB16 zinc finger and BTB domain containing 16 1.05163
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 1.04574
RBM3 RNA binding motif (RNP1, RRM) protein 3 1.04574
ERBB2 erb-b2 receptor tyrosine kinase 2 1.04538
ADCK3 aarF domain containing kinase 3 1.04276
LAMP2 lysosomal-associated membrane protein 2 1.04276
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 1.04276
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.04201
SP1 Sp1 transcription factor 1.04088
NINJ1 ninjurin 1 1.04014
ATF4 activating transcription factor 4 1.03976
HOXA3 homeobox A3 1.03939
ACTB actin, beta 1.03901
CLK1 CDC-like kinase 1 1.03789
WARS tryptophanyl-tRNA synthetase 1.03752
HMG20A high mobility group 20A 1.03715
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.03715
SDF2L1 stromal cell-derived factor 2-like 1 1.03715
C3 complement component 3 1.03604
CAV1 caveolin 1, caveolae protein, 22kDa 1.03604
CD14 CD14 molecule 1.03493
MX1 MX dynamin-like GTPase 1 1.03419
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 1.03271
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 1.03159
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.03084
KLHL41 kelch-like family member 41 1.02971
ALDH1B1 aldehyde dehydrogenase 1 family, member B1 1.02971
TUBB2A tubulin, beta 2A class IIa 1.02896
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase 1.02858
FAM188A family with sequence similarity 188, member A 1.02821
SQSTM1 sequestosome 1 1.02746
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 1.02671
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 1.02634
CFH complement factor H 1.02634
MVP major vault protein 1.02634
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.02522
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 1.0241
APP amyloid beta (A4) precursor protein 1.0241
TNNI3 troponin I type 3 (cardiac) 1.0241
PCNA proliferating cell nuclear antigen 1.02299
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 1.02262
CP ceruloplasmin (ferroxidase) 1.02151
MAP2K3 mitogen-activated protein kinase kinase 3 1.02114
S1PR1 sphingosine-1-phosphate receptor 1 1.02114
SLC35B4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 1.01928
MUC1 mucin 1, cell surface associated 1.01928
MRPS23 mitochondrial ribosomal protein S23 1.01928
AK4 adenylate kinase 4 1.0189
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 1.01852
XPA xeroderma pigmentosum, complementation group A 1.01663
COL6A3 collagen, type VI, alpha 3 1.01625
GSTA4 glutathione S-transferase alpha 4 1.01474
SOD2 superoxide dismutase 2, mitochondrial 1.01437
MAP3K8 mitogen-activated protein kinase kinase kinase 8 1.01399
PHLDA3 pleckstrin homology-like domain, family A, member 3 1.01361
SLCO2B1 solute carrier organic anion transporter family, member 2B1 1.01212
DBP D site of albumin promoter (albumin D-box) binding protein 1.01137
AMZ2 archaelysin family metallopeptidase 2 1.01137
RNF126 ring finger protein 126 1.01099