Multiple sclerosis Gene Set

Dataset GWAS Catalog SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring. (Human Disease Ontology, DOID_2377)
External Link https://www.ebi.ac.uk/gwas/search?query=Multiple sclerosis
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Genes

78 genes associated with the Multiple sclerosis phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
HLA-DRA major histocompatibility complex, class II, DR alpha 2.46192
CLEC16A C-type lectin domain family 16, member A 0.912347
CD58 CD58 molecule 0.888021
C6ORF10 chromosome 6 open reading frame 10 0.870394
EVI5 ecotropic viral integration site 5 0.827738
TAGAP T-cell activation RhoGTPase activating protein 0.824605
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.786836
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.767895
AHI1 Abelson helper integration site 1 0.765464
ZFP36L1 ZFP36 ring finger protein-like 1 0.658916
LOC285626 uncharacterized LOC285626 0.656287
CD86 CD86 molecule 0.656287
IL2RA interleukin 2 receptor, alpha 0.626595
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.626595
LOC101928791 uncharacterized LOC101928791 0.572839
SP140 SP140 nuclear body protein 0.572839
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase 0.572839
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.572839
SLC30A7 solute carrier family 30 (zinc transporter), member 7 0.560615
KIF1B kinesin family member 1B 0.560615
NCOA5 nuclear receptor coactivator 5 0.5451
C1ORF106 chromosome 1 open reading frame 106 0.499091
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 0.499091
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1 0.483518
MALT1 MALT1 paracaspase 0.483518
CD6 CD6 molecule 0.472799
ZNF767P zinc finger family member 767, pseudogene 0.463473
MAPK1 mitogen-activated protein kinase 1 0.463473
DKKL1 dickkopf-like 1 0.463473
ZMIZ1 zinc finger, MIZ-type containing 1 0.455873
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 0.455873
CLECL1 C-type lectin-like 1 0.434785
MERTK MER proto-oncogene, tyrosine kinase 0.434785
MPV17L2 MPV17 mitochondrial membrane protein-like 2 0.434785
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 0.405958
IL7R interleukin 7 receptor 0.405958
BATF basic leucine zipper transcription factor, ATF-like 0.405958
ODF3B outer dense fiber of sperm tails 3B 0.405958
MLANA melan-A 0.389385
LOC100506047 uncharacterized LOC100506047 0.389385
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.377988
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.346786
MANBA mannosidase, beta A, lysosomal 0.342586
ZBTB46 zinc finger and BTB domain containing 46 0.342586
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 0.314454
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.295129
CXCR5 chemokine (C-X-C motif) receptor 5 0.295129
SPEF2 sperm flagellar 2 0.280662
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) 0.266721
SAE1 SUMO1 activating enzyme subunit 1 0.266721
RGS14 regulator of G-protein signaling 14 0.266721
MPHOSPH9 M-phase phosphoprotein 9 0.246511
MYNN myoneurin 0.246511
RAD21L1 RAD21-like 1 (S. pombe) 0.238523
SYK spleen tyrosine kinase 0.22914
VAV2 vav 2 guanine nucleotide exchange factor 0.220915
LOC100128088 matrix metallopeptidase 1-like 0.220915
GPC5 glypican 5 0.220915
PVR poliovirus receptor 0.220915
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.165905
PDZRN4 PDZ domain containing ring finger 4 0.165905
CSMD1 CUB and Sushi multiple domains 1 0.165905
NDFIP1 Nedd4 family interacting protein 1 0.165905
FCRL3 Fc receptor-like 3 0.129504
RREB1 ras responsive element binding protein 1 0.129504
TRIM2 tripartite motif containing 2 0.104568
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12 0.104568
PLCL2 phospholipase C-like 2 0.104568
EGFL6 EGF-like-domain, multiple 6 0.104568
ALPK2 alpha-kinase 2 0.104568
TLL1 tolloid-like 1 0.085234
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.070053
IL12A-AS1 IL12A antisense RNA 1 0.070053
LOC100506023 uncharacterized LOC100506023 0.057619
NCKAP5 NCK-associated protein 5 0.057619
BRINP1 bone morphogenetic protein/retinoic acid inducible neural-specific 1 0.048624
SAMD12 sterile alpha motif domain containing 12 0.048624
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.048624