Multiple Sclerosis Gene Set

Dataset dbGAP Gene-Trait Associations
Category disease or phenotype associations
Type trait
Description A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring. (Human Disease Ontology, DOID_2377)
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Genes

82 genes associated with the trait Multiple Sclerosis in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

Symbol Name Standardized Value
HLA-DRA major histocompatibility complex, class II, DR alpha 2.77373
C6ORF10 chromosome 6 open reading frame 10 1.81672
NOTCH4 notch 4 1.71039
TNXB tenascin XB 1.64709
BAG6 BCL2-associated athanogene 6 1.38963
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 1.20287
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 1.19896
EHMT2 euchromatic histone-lysine N-methyltransferase 2 1.13255
C2 complement component 2 1.11285
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 1.10853
MCCD1 mitochondrial coiled-coil domain 1 1.10853
HLA-DRB9 major histocompatibility complex, class II, DR beta 9 (pseudogene) 1.10332
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.01814
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 1.00047
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.995026
BTNL2 butyrophilin-like 2 0.989992
METTL1 methyltransferase like 1 0.965948
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 0.965948
PSORS1C1 psoriasis susceptibility 1 candidate 1 0.944474
CDSN corneodesmosin 0.944474
NELFE negative elongation factor complex member E 0.932185
CFB complement factor B 0.932185
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase 0.922056
KIF1B kinesin family member 1B 0.907793
CD58 CD58 molecule 0.907793
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.907793
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 0.829829
HLA-DMB major histocompatibility complex, class II, DM beta 0.825651
POU5F1 POU class 5 homeobox 1 0.808779
CD6 CD6 molecule 0.807263
IL2RA interleukin 2 receptor, alpha 0.711358
MLANA melan-A 0.711358
TCF19 transcription factor 19 0.684357
CLEC16A C-type lectin domain family 16, member A 0.609816
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 0.609816
IL7R interleukin 7 receptor 0.585749
SPEF2 sperm flagellar 2 0.567219
TAGAP T-cell activation RhoGTPase activating protein 0.567219
ZMIZ1 zinc finger, MIZ-type containing 1 0.567219
SUMF1 sulfatase modifying factor 1 0.539181
TRIM26 tripartite motif containing 26 0.532217
MPHOSPH9 M-phase phosphoprotein 9 0.527821
RAD21L1 RAD21-like 1 (S. pombe) 0.518003
ZNF433 zinc finger protein 433 0.50084
VAV2 vav 2 guanine nucleotide exchange factor 0.50084
GPC5 glypican 5 0.50084
FLOT1 flotillin 1 0.480163
TRIM10 tripartite motif containing 10 0.458071
HCG9 HLA complex group 9 (non-protein coding) 0.448361
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.443956
LINC01551 long intergenic non-protein coding RNA 1551 0.443956
LEKR1 leucine, glutamate and lysine rich 1 0.443956
CSMD1 CUB and Sushi multiple domains 1 0.443956
PDZRN4 PDZ domain containing ring finger 4 0.443956
RPL5 ribosomal protein L5 0.406869
RELN reelin 0.406869
TRIM2 tripartite motif containing 2 0.378873
NLRP11 NLR family, pyrin domain containing 11 0.378873
BICD1 bicaudal D homolog 1 (Drosophila) 0.378873
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 0.378873
PCSK5 proprotein convertase subtilisin/kexin type 5 0.356676
TRIM40 tripartite motif containing 40 0.354694
TBC1D2 TBC1 domain family, member 2 0.34545
AXDND1 axonemal dynein light chain domain containing 1 0.33862
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.33862
MET MET proto-oncogene, receptor tyrosine kinase 0.33862
CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8 0.323533
IGF2R insulin-like growth factor 2 receptor 0.323533
FOXO3 forkhead box O3 0.323533
POPDC3 popeye domain containing 3 0.310838
BRINP1 bone morphogenetic protein/retinoic acid inducible neural-specific 1 0.310838
SVIL supervillin 0.310838
MXI1 MAX interactor 1, dimerization protein 0.310838
NCKAP5 NCK-associated protein 5 0.310838
ZNRD1-AS1 ZNRD1 antisense RNA 1 0.29992
KCNIP1 Kv channel interacting protein 1 0.29992
SLC44A4 solute carrier family 44, member 4 0.290397
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 0.28197
TRIM15 tripartite motif containing 15 0.267438
HCG18 HLA complex group 18 (non-protein coding) 0.261062
STAU2 staufen double-stranded RNA binding protein 2 0.234424
DCHS2 dachsous cadherin-related 2 0.220667