Multiple Myeloma Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A myeloma that is located_in the plasma cells in bone marrow. (Human Disease Ontology, DOID_9538)
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Genes

241 genes associated with the Multiple Myeloma phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AFF1 AF4/FMR2 family, member 1
AHR aryl hydrocarbon receptor
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AOC1 amine oxidase, copper containing 1
BAX BCL2-associated X protein
BIRC2 baculoviral IAP repeat containing 2
BRAF B-Raf proto-oncogene, serine/threonine kinase
CARD11 caspase recruitment domain family, member 11
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CBX7 chromobox homolog 7
CCND1 cyclin D1
CCR7 chemokine (C-C motif) receptor 7
CD27 CD27 molecule
CD28 CD28 molecule
CD3EAP CD3e molecule, epsilon associated protein
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD5 CD5 molecule
CD70 CD70 molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CD81 CD81 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CETP cholesteryl ester transfer protein, plasma
CFLAR CASP8 and FADD-like apoptosis regulator
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CHUK conserved helix-loop-helix ubiquitous kinase
CINP cyclin-dependent kinase 2 interacting protein
COL18A1 collagen, type XVIII, alpha 1
COL1A1 collagen, type I, alpha 1
CROT carnitine O-octanoyltransferase
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTSS cathepsin S
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
DNAH11 dynein, axonemal, heavy chain 11
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
DTNB dystrobrevin, beta
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
EPHB2 EPH receptor B2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC5 excision repair cross-complementation group 5
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
FADD Fas (TNFRSF6)-associated via death domain
FAM179B family with sequence similarity 179, member B
FAM46C family with sequence similarity 46, member C
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FDPS farnesyl diphosphate synthase
GAN gigaxonin
GBA glucosidase, beta, acid
GJE1 gap junction protein, epsilon 1, 23kDa
GSK3B glycogen synthase kinase 3 beta
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GYS1 glycogen synthase 1 (muscle)
HFE hemochromatosis
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-C major histocompatibility complex, class I, C
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HPSE heparanase
ICAM1 intercellular adhesion molecule 1
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
ICAM5 intercellular adhesion molecule 5, telencephalin
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP1 insulin-like growth factor binding protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL10RB interleukin 10 receptor, beta
IL12A interleukin 12A
IL12B interleukin 12B
IL12RB1 interleukin 12 receptor, beta 1
IL12RB2 interleukin 12 receptor, beta 2
IL13 interleukin 13
IL15 interleukin 15
IL18 interleukin 18
IL19 interleukin 19
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5 interleukin 5
IL6 interleukin 6
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
IL9 interleukin 9
IRF4 interferon regulatory factor 4
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
JAK1 Janus kinase 1
JAK3 Janus kinase 3
KDR kinase insert domain receptor
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT81 keratin 81, type II
LIG4 ligase IV, DNA, ATP-dependent
LTA lymphotoxin alpha
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
MBL2 mannose-binding lectin (protein C) 2, soluble
MIR196A2 microRNA 196a-2
MMP2 matrix metallopeptidase 2
MPO myeloperoxidase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MYD88 myeloid differentiation primary response 88
MYNN myoneurin
NAIP NLR family, apoptosis inhibitory protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NFRKB nuclear factor related to kappaB binding protein
NOTCH1 notch 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR1I3 nuclear receptor subfamily 1, group I, member 3
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PON1 paraoxonase 1
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSORS1C1 psoriasis susceptibility 1 candidate 1
PSORS1C2 psoriasis susceptibility 1 candidate 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RB1 retinoblastoma 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPS19 ribosomal protein S19
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPP1 secreted phosphoprotein 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TANK TRAF family member-associated NFKB activator
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TARBP2 TAR (HIV-1) RNA binding protein 2
TCF4 transcription factor 4
TERC telomerase RNA component
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TLR1 toll-like receptor 1
TLR10 toll-like receptor 10
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR6 toll-like receptor 6
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TRADD TNFRSF1A-associated via death domain
TRAF2 TNF receptor-associated factor 2
TRAF3 TNF receptor-associated factor 3
TRAF5 TNF receptor-associated factor 5
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TYMS thymidylate synthetase
ULK4 unc-51 like kinase 4
VCAM1 vascular cell adhesion molecule 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
XPA xeroderma pigmentosum, complementation group A
XPO5 exportin 5
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)