Motor Neuron Disease Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A neurodegenerative disease that is located_in the motor neurones. (Human Disease Ontology, DOID_231)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D016472
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Genes

139 genes/proteins associated with the disease Motor Neuron Disease from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
PRDX3 peroxiredoxin 3 2.88009
PNPLA6 patatin-like phospholipase domain containing 6 2.88009
VIM vimentin 2.88009
SOD1 superoxide dismutase 1, soluble 2.88009
CAT catalase 1.57114
SOD2 superoxide dismutase 2, mitochondrial 1.55402
IFNG interferon, gamma 1.53086
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.51886
MAPK1 mitogen-activated protein kinase 1 1.48196
IL6 interleukin 6 1.47915
TGFB1 transforming growth factor, beta 1 1.46832
FAS Fas cell surface death receptor 1.46542
HMOX1 heme oxygenase 1 1.46146
BAX BCL2-associated X protein 1.45036
TNF tumor necrosis factor 1.44735
DDIT3 DNA-damage-inducible transcript 3 1.44409
GSR glutathione reductase 1.42047
BCL2L1 BCL2-like 1 1.39282
IL1B interleukin 1, beta 1.39226
GADD45A growth arrest and DNA-damage-inducible, alpha 1.36876
F2 coagulation factor II (thrombin) 1.36019
GSTM1 glutathione S-transferase mu 1 1.3443
TP53 tumor protein p53 1.34198
ACO2 aconitase 2, mitochondrial 1.3385
GCLC glutamate-cysteine ligase, catalytic subunit 1.33672
HSPA8 heat shock 70kDa protein 8 1.33316
EGR1 early growth response 1 1.33169
NOS2 nitric oxide synthase 2, inducible 1.33052
JUN jun proto-oncogene 1.31686
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 1.31476
NAMPT nicotinamide phosphoribosyltransferase 1.31357
DUSP1 dual specificity phosphatase 1 1.30512
FLT1 fms-related tyrosine kinase 1 1.30117
MMP2 matrix metallopeptidase 2 1.29595
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.28088
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.27626
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.25838
BIRC2 baculoviral IAP repeat containing 2 1.25838
RRM2 ribonucleotide reductase M2 1.254
MAPK3 mitogen-activated protein kinase 3 1.25369
GPX1 glutathione peroxidase 1 1.25369
GPX3 glutathione peroxidase 3 1.2456
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.2437
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 1.2415
LEP leptin 1.2393
SELE selectin E 1.23899
NELFA negative elongation factor complex member A 1.2336
NFE2L2 nuclear factor, erythroid 2-like 2 1.23328
BTG2 BTG family, member 2 1.22696
CD14 CD14 molecule 1.22048
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.21887
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.21695
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.21663
CTSD cathepsin D 1.21435
NQO1 NAD(P)H dehydrogenase, quinone 1 1.21173
PRKCD protein kinase C, delta 1.20719
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.20719
CP ceruloplasmin (ferroxidase) 1.20687
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.2059
CYCS cytochrome c, somatic 1.19802
SLCO4C1 solute carrier organic anion transporter family, member 4C1 1.19445
APP amyloid beta (A4) precursor protein 1.19379
MT2A metallothionein 2A 1.19312
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.19179
BIRC3 baculoviral IAP repeat containing 3 1.18948
VEGFA vascular endothelial growth factor A 1.18226
MKI67 marker of proliferation Ki-67 1.17629
GSTO1 glutathione S-transferase omega 1 1.17134
IGF1 insulin-like growth factor 1 (somatomedin C) 1.16967
TOP2A topoisomerase (DNA) II alpha 170kDa 1.16799
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 1.16799
COX1 1.16733
TLR4 toll-like receptor 4 1.165
BCL2 B-cell CLL/lymphoma 2 1.16203
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.1617
GHR growth hormone receptor 1.15357
EPAS1 endothelial PAS domain protein 1 1.14989
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.14885
ACHE acetylcholinesterase (Yt blood group) 1.1461
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.13929
HSPB1 heat shock 27kDa protein 1 1.13827
CXCL10 chemokine (C-X-C motif) ligand 10 1.13484
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.13449
FOS FBJ murine osteosarcoma viral oncogene homolog 1.13211
CCNE1 cyclin E1 1.13109
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.12495
FKBP5 FK506 binding protein 5 1.12357
PRL prolactin 1.12288
CXCL8 chemokine (C-X-C motif) ligand 8 1.12254
BMP4 bone morphogenetic protein 4 1.12014
AVP arginine vasopressin 1.11673
S100A9 S100 calcium binding protein A9 1.11186
FN1 fibronectin 1 1.11186
GSTP1 glutathione S-transferase pi 1 1.10631
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 1.10069
FNBP1 formin binding protein 1 1.09716
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.09681
S100A8 S100 calcium binding protein A8 1.09681
PDHB pyruvate dehydrogenase (lipoamide) beta 1.08797
CCNG1 cyclin G1 1.08513
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.08407
INHA inhibin, alpha 1.08055
CXCL2 chemokine (C-X-C motif) ligand 2 1.08055
MMP9 matrix metallopeptidase 9 1.07768
MGST1 microsomal glutathione S-transferase 1 1.07553
CNR1 cannabinoid receptor 1 (brain) 1.0637
SORT1 sortilin 1 1.06225
MDK midkine (neurite growth-promoting factor 2) 1.059
TUBA4A tubulin, alpha 4a 1.059
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 1.05721
GRB2 growth factor receptor-bound protein 2 1.05386
VCAM1 vascular cell adhesion molecule 1 1.05163
ACTB actin, beta 1.05089
TIMP2 TIMP metallopeptidase inhibitor 2 1.04352
SQSTM1 sequestosome 1 1.03939
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.03939
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 1.03715
CXCL12 chemokine (C-X-C motif) ligand 12 1.03604
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.03456
CCND1 cyclin D1 1.03456
FMO3 flavin containing monooxygenase 3 1.03456
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 1.03419
GFAP glial fibrillary acidic protein 1.03009
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 1.02746
PARP1 poly (ADP-ribose) polymerase 1 1.02708
COL6A3 collagen, type VI, alpha 3 1.02671
IL1A interleukin 1, alpha 1.02671
COX4I1 cytochrome c oxidase subunit IV isoform 1 1.02522
ATF5 activating transcription factor 5 1.02447
NOS1 nitric oxide synthase 1 (neuronal) 1.02447
IL2 interleukin 2 1.0241
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.02373
MT1A metallothionein 1A 1.02225
EDN1 endothelin 1 1.02003
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.02003
LPIN1 lipin 1 1.01739
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 1.01739
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.01663
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.01137