Mood Disorders Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

277 genes associated with the Mood Disorders phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABI3BP ABI family, member 3 (NESH) binding protein
ACE angiotensin I converting enzyme
ACHE acetylcholinesterase (Yt blood group)
ACTN2 actinin, alpha 2
ADCY7 adenylate cyclase 7
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADH6 alcohol dehydrogenase 6 (class V)
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
ADORA2A adenosine A2a receptor
ADRA1A adrenoceptor alpha 1A
ADRA2A adrenoceptor alpha 2A
ADRA2B adrenoceptor alpha 2B
ADRA2C adrenoceptor alpha 2C
ADRB2 adrenoceptor beta 2, surface
ADRBK2 adrenergic, beta, receptor kinase 2
AKR1C4 aldo-keto reductase family 1, member C4
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKK1 ankyrin repeat and kinase domain containing 1
APOE apolipoprotein E
AR androgen receptor
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ARRB2 arrestin, beta 2
AUTS2 autism susceptibility candidate 2
AVP arginine vasopressin
AVPR1A arginine vasopressin receptor 1A
AVPR1B arginine vasopressin receptor 1B
BDNF brain-derived neurotrophic factor
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CARTPT CART prepropeptide
CAT catalase
CCK cholecystokinin
CCKAR cholecystokinin A receptor
CCKBR cholecystokinin B receptor
CCL2 chemokine (C-C motif) ligand 2
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CHRM1 cholinergic receptor, muscarinic 1
CHRM2 cholinergic receptor, muscarinic 2
CHRM3 cholinergic receptor, muscarinic 3
CHRM4 cholinergic receptor, muscarinic 4
CHRM5 cholinergic receptor, muscarinic 5
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLINT1 clathrin interactor 1
CLOCK clock circadian regulator
CNR1 cannabinoid receptor 1 (brain)
CNTN5 contactin 5
CNTN6 contactin 6
COMT catechol-O-methyltransferase
CORT cortistatin
CREB1 cAMP responsive element binding protein 1
CRH corticotropin releasing hormone
CRHBP corticotropin releasing hormone binding protein
CRHR1 corticotropin releasing hormone receptor 1
CRHR2 corticotropin releasing hormone receptor 2
CRIPT cysteine-rich PDZ-binding protein
CRP C-reactive protein, pentraxin-related
CRY1 cryptochrome circadian clock 1
CRY2 cryptochrome circadian clock 2
CSNK1E casein kinase 1, epsilon
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DAO D-amino-acid oxidase
DAOA D-amino acid oxidase activator
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DBP D site of albumin promoter (albumin D-box) binding protein
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DGCR6 DiGeorge syndrome critical region gene 6
DISC1 disrupted in schizophrenia 1
DLG1 discs, large homolog 1 (Drosophila)
DLG2 discs, large homolog 2 (Drosophila)
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
DRD5 dopamine receptor D5
EDN1 endothelin 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FAAH fatty acid amide hydrolase
FEV FEV (ETS oncogene family)
FKBP5 FK506 binding protein 5
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FZD3 frizzled class receptor 3
FZD9 frizzled class receptor 9
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GAL galanin/GMAP prepropeptide
GALR1 galanin receptor 1
GALR3 galanin receptor 3
GCHFR GTP cyclohydrolase I feedback regulator
GDF2 growth differentiation factor 2
GLO1 glyoxalase I
GLRA1 glycine receptor, alpha 1
GLRA2 glycine receptor, alpha 2
GLRB glycine receptor, beta
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNRHR2 gonadotropin-releasing hormone (type 2) receptor 2, pseudogene
GPHN gephyrin
GPR50 G protein-coupled receptor 50
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRIK1 glutamate receptor, ionotropic, kainate 1
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
GRM1 glutamate receptor, metabotropic 1
GRM2 glutamate receptor, metabotropic 2
GRM3 glutamate receptor, metabotropic 3
GRM5 glutamate receptor, metabotropic 5
GRM7 glutamate receptor, metabotropic 7
GRM8 glutamate receptor, metabotropic 8
GSK3B glycogen synthase kinase 3 beta
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HCRT hypocretin (orexin) neuropeptide precursor
HCRTR1 hypocretin (orexin) receptor 1
HCRTR2 hypocretin (orexin) receptor 2
HES6 hes family bHLH transcription factor 6
HOMER1 homer scaffolding protein 1
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
HSPA1L heat shock 70kDa protein 1-like
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
HTT huntingtin
IFNG interferon, gamma
IL10 interleukin 10
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JUN jun proto-oncogene
LEP leptin
LIN7C lin-7 homolog C (C. elegans)
LRRK2 leucine-rich repeat kinase 2
MAGEL2 melanoma antigen family L2
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MPDZ multiple PDZ domain protein
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NFIL3 nuclear factor, interleukin 3 regulated
NGF nerve growth factor (beta polypeptide)
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1
NLGN1 neuroligin 1
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NOS2 nitric oxide synthase 2, inducible
NOTCH4 notch 4
NPAS2 neuronal PAS domain protein 2
NPPC natriuretic peptide C
NPR3 natriuretic peptide receptor 3
NPTX2 neuronal pentraxin II
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NPY2R neuropeptide Y receptor Y2
NPY5R neuropeptide Y receptor Y5
NR1D1 nuclear receptor subfamily 1, group D, member 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR3C2 nuclear receptor subfamily 3, group C, member 2
NRG3 neuregulin 3
NRXN3 neurexin 3
NSF N-ethylmaleimide-sensitive factor
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
NTSR1 neurotensin receptor 1 (high affinity)
NTSR2 neurotensin receptor 2
OATP1 ornithine aminotransferase pseudogene 1
OPRD1 opioid receptor, delta 1
OPRK1 opioid receptor, kappa 1
OPRL1 opiate receptor-like 1
OPRM1 opioid receptor, mu 1
OXT oxytocin/neurophysin I prepropeptide
OXTR oxytocin receptor
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PAWR PRKC, apoptosis, WT1, regulator
PBRM1 polybromo 1
PDYN prodynorphin
PENK proenkephalin
PER1 period circadian clock 1
PER2 period circadian clock 2
PER3 period circadian clock 3
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCB4 phospholipase C, beta 4
PLCD1 phospholipase C, delta 1
PNOC prepronociceptin
POMC proopiomelanocortin
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme
PRKCE protein kinase C, epsilon
PRL prolactin
PRLR prolactin receptor
PRODH proline dehydrogenase (oxidase) 1
RORA RAR-related orphan receptor A
RTN4R reticulon 4 receptor
S100B S100 calcium binding protein B
SAT1 spermidine/spermine N1-acetyltransferase 1
SCT secretin
SDK1 sidekick cell adhesion molecule 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7
SMOX spermine oxidase
SMS spermine synthase
SOD2 superoxide dismutase 2, mitochondrial
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SSTR5 somatostatin receptor 5
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
TAAR6 trace amine associated receptor 6
TAC1 tachykinin, precursor 1
TACR1 tachykinin receptor 1
TBX1 T-box 1
TFIP11 tuftelin interacting protein 11
TIMELESS timeless circadian clock
TNF tumor necrosis factor
TPH1 tryptophan hydroxylase 1
TPH2 tryptophan hydroxylase 2
TRH thyrotropin-releasing hormone
TSNAX translin-associated factor X
TSPO translocator protein (18kDa)
UST uronyl-2-sulfotransferase
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VIP vasoactive intestinal peptide
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae)
WFS1 Wolfram syndrome 1 (wolframin)
XK X-linked Kx blood group