Mitral Valve Prolapse Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A mitral valve disease where one or both of the cusps of the mitral valve bulge or collapse backward in the left atrium during systole. (Human Disease Ontology, DOID_988)
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19 genes associated with the Mitral Valve Prolapse phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
BDNF brain-derived neurotrophic factor
COL3A1 collagen, type III, alpha 1
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
FBN1 fibrillin 1
HSPG2 heparan sulfate proteoglycan 2
IL10 interleukin 10
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
PLAU plasminogen activator, urokinase
TGFB1 transforming growth factor, beta 1
TSHR thyroid stimulating hormone receptor