Mismatch Repair Gene Set

Dataset Reactome Pathways
Category structural or functional annotations
Type pathway
Description A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. (Gene Ontology, GO_0006298)
External Link http://www.reactome.org/PathwayBrowser/#/R-HSA-5358508
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Genes

16 proteins participating in the Mismatch Repair pathway from the Reactome Pathways dataset.

Symbol Name
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
EXO1 exonuclease 1
LIG1 ligase I, DNA, ATP-dependent
MLH1 mutL homolog 1
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MSH6 mutS homolog 6
PCNA proliferating cell nuclear antigen
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLD3 polymerase (DNA-directed), delta 3, accessory subunit
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
RPA1 replication protein A1, 70kDa
RPA2 replication protein A2, 32kDa
RPA3 replication protein A3, 14kDa