Migraine Disorders Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

200 genes associated with the Migraine Disorders phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional)
ADD1 adducin 1 (alpha)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADRA2B adrenoceptor alpha 2B
ADRB2 adrenoceptor beta 2, surface
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AJAP1 adherens junctions associated protein 1
ANKK1 ankyrin repeat and kinase domain containing 1
APOA1BP apolipoprotein A-I binding protein
APOE apolipoprotein E
AQP4 aquaporin 4
AR androgen receptor
ASTN2 astrotactin 2
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
BACE1 beta-site APP-cleaving enzyme 1
BDNF brain-derived neurotrophic factor
C3 complement component 3
C5 complement component 5
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CALCA calcitonin-related polypeptide alpha
CBS cystathionine-beta-synthase
CCL11 chemokine (C-C motif) ligand 11
CCR3 chemokine (C-C motif) receptor 3
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CNR1 cannabinoid receptor 1 (brain)
COMT catechol-O-methyltransferase
CPQ carboxypeptidase Q
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DIDO1 death inducer-obliterator 1
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
DRD5 dopamine receptor D5
EDN1 endothelin 1
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
EFHC1 EF-hand domain (C-terminal) containing 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
F13A1 coagulation factor XIII, A1 polypeptide
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
F8 coagulation factor VIII, procoagulant component
FGB fibrinogen beta chain
FHL5 four and a half LIM domains 5
FMR1 fragile X mental retardation 1
FSHR follicle stimulating hormone receptor
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GC group-specific component (vitamin D binding protein)
GNAS GNAS complex locus
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRIA3 glutamate receptor, ionotropic, AMPA 3
GRIA4 glutamate receptor, ionotropic, AMPA 4
GRM7 glutamate receptor, metabotropic 7
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HCRTR1 hypocretin (orexin) receptor 1
HCRTR2 hypocretin (orexin) receptor 2
HFE hemochromatosis
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HNMT histamine N-methyltransferase
HRH3 histamine receptor H3
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
ICAM1 intercellular adhesion molecule 1
IL10 interleukin 10
IL13 interleukin 13
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
IL9 interleukin 9
INSR insulin receptor
IRX4 iroquois homeobox 4
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3
KCNG4 potassium channel, voltage gated modifier subfamily G, member 4
KCNK18 potassium channel, two pore domain subfamily K, member 18
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3
LDLR low density lipoprotein receptor
LRP1 low density lipoprotein receptor-related protein 1
LTA lymphotoxin alpha
LTC4S leukotriene C4 synthase
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MDFI MyoD family inhibitor
MEF2D myocyte enhancer factor 2D
MEP1A meprin A, alpha (PABA peptide hydrolase)
MEPE matrix extracellular phosphoglycoprotein
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MT-ND4 NADH dehydrogenase, subunit 4 (complex I)
MT-TL1 tRNA
MTDH metadherin
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
NGFR nerve growth factor receptor
NNMT nicotinamide N-methyltransferase
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH3 notch 3
NOTCH4 notch 4
NPPA natriuretic peptide A
NRIP1 nuclear receptor interacting protein 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
PGR progesterone receptor
PHACTR1 phosphatase and actin regulator 1
POLG polymerase (DNA directed), gamma
PON1 paraoxonase 1
PRDM16 PR domain containing 16
PRNP prion protein
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RHAG Rh-associated glycoprotein
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCN1A sodium channel, voltage gated, type I alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELE selectin E
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC25A27 solute carrier family 25, member 27
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STX1A syntaxin 1A (brain)
SUGCT succinyl-CoA:glutarate-CoA transferase
TBC1D7 TBC1 domain family, member 7
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TH tyrosine hydroxylase
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPH1 tryptophan hydroxylase 1
TPH2 tryptophan hydroxylase 2
TRPA1 transient receptor potential cation channel, subfamily A, member 1
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TRPC4 transient receptor potential cation channel, subfamily C, member 4
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TRPM6 transient receptor potential cation channel, subfamily M, member 6
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TRPM8 transient receptor potential cation channel, subfamily M, member 8
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV2 transient receptor potential cation channel, subfamily V, member 2
TRPV3 transient receptor potential cation channel, subfamily V, member 3
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TSPAN2 tetraspanin 2
TYMS thymidylate synthetase
USP9Y ubiquitin specific peptidase 9, Y-linked
VCAM1 vascular cell adhesion molecule 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VWA8 von Willebrand factor A domain containing 8