Metabolic Syndrome X Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description OMIM mapping confirmed by DO. [SN]. (Human Disease Ontology, DOID_14221)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D024821
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Genes

150 genes/proteins associated with the disease Metabolic Syndrome X from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
IL18 interleukin 18 2.88009
CRP C-reactive protein, pentraxin-related 2.88009
SHBG sex hormone-binding globulin 2.88009
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 2.88009
LBP lipopolysaccharide binding protein 2.88009
HMGA1 high mobility group AT-hook 1 2.88009
CCL2 chemokine (C-C motif) ligand 2 2.88009
ADIPOQ adiponectin, C1Q and collagen domain containing 2.88009
PON1 paraoxonase 1 2.88009
TRIB3 tribbles pseudokinase 3 2.88009
INS insulin 2.88009
NR1I2 nuclear receptor subfamily 1, group I, member 2 2.88009
NR1I3 nuclear receptor subfamily 1, group I, member 3 2.88009
LEP leptin 2.88009
IL6 interleukin 6 2.88009
NOS3 nitric oxide synthase 3 (endothelial cell) 2.88009
RETN resistin 2.88009
NEIL1 nei endonuclease VIII-like 1 (E. coli) 2.88009
SIRT1 sirtuin 1 2.88009
SREBF1 sterol regulatory element binding transcription factor 1 1.95737
TNF tumor necrosis factor 1.95072
FASN fatty acid synthase 1.94015
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.91067
LPL lipoprotein lipase 1.86756
PPARG peroxisome proliferator-activated receptor gamma 1.79254
CAT catalase 1.75023
ALB albumin 1.73129
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.7185
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 1.66576
NCF1 neutrophil cytosolic factor 1 1.6491
EDN1 endothelin 1 1.62983
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.58113
MAPK1 mitogen-activated protein kinase 1 1.55378
NOS2 nitric oxide synthase 2, inducible 1.52388
IL1B interleukin 1, beta 1.51632
APOC3 apolipoprotein C-III 1.5133
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.48838
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.47889
TGFB1 transforming growth factor, beta 1 1.47322
APOB apolipoprotein B 1.46754
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.46356
SOD1 superoxide dismutase 1, soluble 1.45352
FOS FBJ murine osteosarcoma viral oncogene homolog 1.45352
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.45299
IGF1 insulin-like growth factor 1 (somatomedin C) 1.44056
MAPK3 mitogen-activated protein kinase 3 1.41396
SCARB1 scavenger receptor class B, member 1 1.41257
VCAM1 vascular cell adhesion molecule 1 1.39507
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.38724
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.38015
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 1.37987
TP53 tumor protein p53 1.37874
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.37761
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.37075
LDLR low density lipoprotein receptor 1.36763
CREB1 cAMP responsive element binding protein 1 1.35589
CD36 CD36 molecule (thrombospondin receptor) 1.34401
GSK3B glycogen synthase kinase 3 beta 1.33701
APOE apolipoprotein E 1.33701
PPARA peroxisome proliferator-activated receptor alpha 1.3311
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.31626
BCL2 B-cell CLL/lymphoma 2 1.30177
GCG glucagon 1.30056
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.29719
HMOX1 heme oxygenase 1 1.29103
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.27966
CP ceruloplasmin (ferroxidase) 1.27471
AHR aryl hydrocarbon receptor 1.26236
ADIPOR2 adiponectin receptor 2 1.2596
BDNF brain-derived neurotrophic factor 1.25028
SOD2 superoxide dismutase 2, mitochondrial 1.24244
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.23837
CYBB cytochrome b-245, beta polypeptide 1.22371
NPPB natriuretic peptide B 1.21791
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 1.2137
MMP2 matrix metallopeptidase 2 1.21108
IFNG interferon, gamma 1.20848
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 1.20526
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.20394
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.19999
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic 1.19509
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.19412
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 1.18849
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.18521
BAX BCL2-associated X protein 1.18424
TH tyrosine hydroxylase 1.18424
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.18359
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.17563
LEPR leptin receptor 1.17399
CPT1A carnitine palmitoyltransferase 1A (liver) 1.169
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.16766
CROT carnitine O-octanoyltransferase 1.16368
CCL3 chemokine (C-C motif) ligand 3 1.16302
FABP4 fatty acid binding protein 4, adipocyte 1.1607
TIMP2 TIMP metallopeptidase inhibitor 2 1.1607
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.15865
VEGFA vascular endothelial growth factor A 1.15526
JUN jun proto-oncogene 1.15458
NOX4 NADPH oxidase 4 1.15189
NR1H3 nuclear receptor subfamily 1, group H, member 3 1.15189
EGR1 early growth response 1 1.14989
FAS Fas cell surface death receptor 1.14781
GSTP1 glutathione S-transferase pi 1 1.14747
FN1 fibronectin 1 1.14507
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 1.14473
GFAP glial fibrillary acidic protein 1.14268
INSR insulin receptor 1.1403
ICAM1 intercellular adhesion molecule 1 1.13793
REN renin 1.13655
ALAD aminolevulinate dehydratase 1.12703
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1.12461
NFE2L2 nuclear factor, erythroid 2-like 2 1.12357
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 1.12357
CCL5 chemokine (C-C motif) ligand 5 1.12117
EDNRA endothelin receptor type A 1.11431
FGF9 fibroblast growth factor 9 1.1136
PYY peptide YY 1.10175
SPP1 secreted phosphoprotein 1 1.09963
APOA1 apolipoprotein A-I 1.09576
G6PD glucose-6-phosphate dehydrogenase 1.09436
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.09226
NRF1 nuclear respiratory factor 1 1.08833
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.0869
NPPA natriuretic peptide A 1.08619
XDH xanthine dehydrogenase 1.08619
PON2 paraoxonase 2 1.08266
CFD complement factor D (adipsin) 1.08231
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 1.07447
CPT2 carnitine palmitoyltransferase 2 1.07376
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 1.07376
CXCL8 chemokine (C-X-C motif) ligand 8 1.07022
PLP1 proteolipid protein 1 1.06917
NPY neuropeptide Y 1.06225
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 1.06188
CCK cholecystokinin 1.06008
SGK1 serum/glucocorticoid regulated kinase 1 1.04941
CALM1 calmodulin 1 (phosphorylase kinase, delta) 1.04611
CCND1 cyclin D1 1.04574
APP amyloid beta (A4) precursor protein 1.04314
PCNA proliferating cell nuclear antigen 1.04239
IL10 interleukin 10 1.03864
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.03678
ATF4 activating transcription factor 4 1.03567
PRL prolactin 1.03493
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.03419
DRD2 dopamine receptor D2 1.02783
PTH1R parathyroid hormone 1 receptor 1.02746
CDK2 cyclin-dependent kinase 2 1.0241
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.01966
KLK1 kallikrein 1 1.01174