Metabolic Diseases Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

100 genes associated with the Metabolic Diseases phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACE angiotensin I converting enzyme
ACHE acetylcholinesterase (Yt blood group)
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
ADGRV1 adhesion G protein-coupled receptor V1
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGTR1 angiotensin II receptor, type 1
ANGPTL3 angiopoietin-like 3
APOA1 apolipoprotein A-I
APOE apolipoprotein E
AQP7 aquaporin 7
ASTN2 astrotactin 2
ATF7IP2 activating transcription factor 7 interacting protein 2
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCHE butyrylcholinesterase
BHMT betaine--homocysteine S-methyltransferase
BMP4 bone morphogenetic protein 4
CBS cystathionine-beta-synthase
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CETP cholesteryl ester transfer protein, plasma
CILP2 cartilage intermediate layer protein 2
COL5A2 collagen, type V, alpha 2
CPEB4 cytoplasmic polyadenylation element binding protein 4
CST1 cystatin SN
CTSS cathepsin S
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
DHFR dihydrofolate reductase
DNM3 dynamin 3
DOCK7 dedicator of cytokinesis 7
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
FABP2 fatty acid binding protein 2, intestinal
FHOD3 formin homology 2 domain containing 3
FTO fat mass and obesity associated
GATA4 GATA binding protein 4
GBE1 glucan (1,4-alpha-), branching enzyme 1
GHR growth hormone receptor
GRB14 growth factor receptor-bound protein 14
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4
HFE hemochromatosis
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXC13 homeobox C13
IGF2 insulin-like growth factor 2
IL1R1 interleukin 1 receptor, type I
IL6 interleukin 6
IRS1 insulin receptor substrate 1
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JAK2 Janus kinase 2
LDLR low density lipoprotein receptor
LEPR leptin receptor
LIPC lipase, hepatic
LPL lipoprotein lipase
LY86 lymphocyte antigen 86
LYPLAL1 lysophospholipase-like 1
MEIS2 Meis homeobox 2
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MTTP microsomal triglyceride transfer protein
MYL2 myosin, light chain 2, regulatory, cardiac, slow
NFE2L3 nuclear factor, erythroid 2-like 3
NISCH nischarin
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PON1 paraoxonase 1
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSRC1 proline/serine-rich coiled-coil 1
PTS 6-pyruvoyltetrahydropterin synthase
RETN resistin
RLN3 relaxin 3
RNF144A ring finger protein 144A
RSPO3 R-spondin 3
RXFP3 relaxin/insulin-like family peptide receptor 3
RXFP4 relaxin/insulin-like family peptide receptor 4
SELE selectin E
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SLC19A1 solute carrier family 19 (folate transporter), member 1
SORT1 sortilin 1
SOX5 SRY (sex determining region Y)-box 5
STARD3 StAR-related lipid transfer (START) domain containing 3
STK11 serine/threonine kinase 11
TBX15 T-box 15
TCN2 transcobalamin II
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TREML2 triggering receptor expressed on myeloid cells-like 2
UBASH3B ubiquitin associated and SH3 domain containing B
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VIMP VCP-interacting membrane selenoprotein
ZNRF3 zinc and ring finger 3