Mental Disorders Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

439 genes associated with the Mental Disorders phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
AANAT aralkylamine N-acetyltransferase
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACE angiotensin I converting enzyme
ACHE acetylcholinesterase (Yt blood group)
ACTN2 actinin, alpha 2
ADA adenosine deaminase
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
ADORA2A adenosine A2a receptor
ADORA2B adenosine A2b receptor
ADORA3 adenosine A3 receptor
ADRA1A adrenoceptor alpha 1A
ADRA1B adrenoceptor alpha 1B
ADRA1D adrenoceptor alpha 1D
ADRA2A adrenoceptor alpha 2A
ADRA2C adrenoceptor alpha 2C
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRBK2 adrenergic, beta, receptor kinase 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AKAP9 A kinase (PRKA) anchor protein 9
ALAD aminolevulinate dehydratase
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKK1 ankyrin repeat and kinase domain containing 1
APOE apolipoprotein E
AR androgen receptor
ARHGAP35 Rho GTPase activating protein 35
ASTN1 astrotactin 1
ASTN2 astrotactin 2
ATF4 activating transcription factor 4
ATF5 activating transcription factor 5
ATP10A ATPase, class V, type 10A
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP7B ATPase, Cu++ transporting, beta polypeptide
AUTS2 autism susceptibility candidate 2
AVP arginine vasopressin
AVPR1A arginine vasopressin receptor 1A
AVPR1B arginine vasopressin receptor 1B
AVPR2 arginine vasopressin receptor 2
BCHE butyrylcholinesterase
BDKRB1 bradykinin receptor B1
BDKRB2 bradykinin receptor B2
BDNF brain-derived neurotrophic factor
CALCA calcitonin-related polypeptide alpha
CALCB calcitonin-related polypeptide beta
CAMK1 calcium/calmodulin-dependent protein kinase I
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CARTPT CART prepropeptide
CCK cholecystokinin
CCKAR cholecystokinin A receptor
CCKBR cholecystokinin B receptor
CDH10 cadherin 10, type 2 (T2-cadherin)
CDH9 cadherin 9, type 2 (T1-cadherin)
CHAT choline O-acetyltransferase
CHRM1 cholinergic receptor, muscarinic 1
CHRM2 cholinergic receptor, muscarinic 2
CHRM3 cholinergic receptor, muscarinic 3
CHRM5 cholinergic receptor, muscarinic 5
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle)
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CHRND cholinergic receptor, nicotinic, delta (muscle)
CHRNE cholinergic receptor, nicotinic, epsilon (muscle)
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
CLINT1 clathrin interactor 1
CLN3 ceroid-lipofuscinosis, neuronal 3
CNR1 cannabinoid receptor 1 (brain)
CNTF ciliary neurotrophic factor
CNTFR ciliary neurotrophic factor receptor
CNTN1 contactin 1
CNTN2 contactin 2 (axonal)
CNTN3 contactin 3 (plasmacytoma associated)
CNTN5 contactin 5
CNTN6 contactin 6
CNTNAP1 contactin associated protein 1
CNTNAP2 contactin associated protein-like 2
COMT catechol-O-methyltransferase
CORT cortistatin
CRH corticotropin releasing hormone
CRHBP corticotropin releasing hormone binding protein
CRHR1 corticotropin releasing hormone receptor 1
CRHR2 corticotropin releasing hormone receptor 2
CRIPT cysteine-rich PDZ-binding protein
CRTC1 CREB regulated transcription coactivator 1
CSMD1 CUB and Sushi multiple domains 1
CSNK1D casein kinase 1, delta
CSNK1E casein kinase 1, epsilon
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DEAF1 DEAF1 transcription factor
DGCR6 DiGeorge syndrome critical region gene 6
DISC1 disrupted in schizophrenia 1
DLG1 discs, large homolog 1 (Drosophila)
DLG2 discs, large homolog 2 (Drosophila)
DLG3 discs, large homolog 3 (Drosophila)
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DLX2 distal-less homeobox 2
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
DRD5 dopamine receptor D5
DTNBP1 dystrobrevin binding protein 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EN1 engrailed homeobox 1
ESR1 estrogen receptor 1
FAAH fatty acid amide hydrolase
FAM120C family with sequence similarity 120C
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FKBP5 FK506 binding protein 5
FMR1 fragile X mental retardation 1
FOXP2 forkhead box P2
FUS FUS RNA binding protein
FZD9 frizzled class receptor 9
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene)
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GAL galanin/GMAP prepropeptide
GALR1 galanin receptor 1
GALR2 galanin receptor 2
GALR3 galanin receptor 3
GDF2 growth differentiation factor 2
GDNF glial cell derived neurotrophic factor
GHRH growth hormone releasing hormone
GHRHR growth hormone releasing hormone receptor
GLO1 glyoxalase I
GLRA1 glycine receptor, alpha 1
GLRA2 glycine receptor, alpha 2
GLRA3 glycine receptor, alpha 3
GLRB glycine receptor, beta
GMFB glia maturation factor, beta
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GNRH2 gonadotropin-releasing hormone 2
GNRHR gonadotropin-releasing hormone receptor
GNRHR2 gonadotropin-releasing hormone (type 2) receptor 2, pseudogene
GPX1 glutathione peroxidase 1
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRIA3 glutamate receptor, ionotropic, AMPA 3
GRIA4 glutamate receptor, ionotropic, AMPA 4
GRIK1 glutamate receptor, ionotropic, kainate 1
GRIK2 glutamate receptor, ionotropic, kainate 2
GRIK3 glutamate receptor, ionotropic, kainate 3
GRIK4 glutamate receptor, ionotropic, kainate 4
GRIK5 glutamate receptor, ionotropic, kainate 5
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
GRIP1 glutamate receptor interacting protein 1
GRM2 glutamate receptor, metabotropic 2
GRM3 glutamate receptor, metabotropic 3
GRM4 glutamate receptor, metabotropic 4
GRM5 glutamate receptor, metabotropic 5
GRM6 glutamate receptor, metabotropic 6
GRM7 glutamate receptor, metabotropic 7
GRM8 glutamate receptor, metabotropic 8
GRP gastrin-releasing peptide
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HCRTR1 hypocretin (orexin) receptor 1
HCRTR2 hypocretin (orexin) receptor 2
HOMER1 homer scaffolding protein 1
HOMER2 homer scaffolding protein 2
HOXA1 homeobox A1
HSPG2 heparan sulfate proteoglycan 2
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
HTT huntingtin
IFNG interferon, gamma
IL10 interleukin 10
IL12A interleukin 12A
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
KNG1 kininogen 1
L1CAM L1 cell adhesion molecule
LEP leptin
LEPR leptin receptor
LHCGR luteinizing hormone/choriogonadotropin receptor
LIF leukemia inhibitory factor
LYN LYN proto-oncogene, Src family tyrosine kinase
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MAP1A microtubule-associated protein 1A
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MECP2 methyl CpG binding protein 2
MLH1 mutL homolog 1
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MSH2 mutS homolog 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NBEA neurobeachin
NCAM1 neural cell adhesion molecule 1
NCAM2 neural cell adhesion molecule 2
NDEL1 nudE neurodevelopment protein 1-like 1
NEUROD1 neuronal differentiation 1
NEUROD2 neuronal differentiation 2
NEUROD4 neuronal differentiation 4
NEUROG1 neurogenin 1
NGF nerve growth factor (beta polypeptide)
NGFR nerve growth factor receptor
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1
NKAIN1 Na+/K+ transporting ATPase interacting 1
NLGN1 neuroligin 1
NLGN2 neuroligin 2
NOS1 nitric oxide synthase 1 (neuronal)
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NOS2 nitric oxide synthase 2, inducible
NOS2P1 nitric oxide synthase 2 pseudogene 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH3 notch 3
NPPA natriuretic peptide A
NPPB natriuretic peptide B
NPPC natriuretic peptide C
NPR1 natriuretic peptide receptor 1
NPR2 natriuretic peptide receptor 2
NPR3 natriuretic peptide receptor 3
NPY neuropeptide Y
NPY2R neuropeptide Y receptor Y2
NPY5R neuropeptide Y receptor Y5
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1I3 nuclear receptor subfamily 1, group I, member 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR3C2 nuclear receptor subfamily 3, group C, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRCAM neuronal cell adhesion molecule
NRG1 neuregulin 1
NRG2 neuregulin 2
NRG3 neuregulin 3
NRP1 neuropilin 1
NRXN1 neurexin 1
NRXN2 neurexin 2
NRXN3 neurexin 3
NSD1 nuclear receptor binding SET domain protein 1
NSF N-ethylmaleimide-sensitive factor
NSUN4 NOP2/Sun domain family, member 4
NTF3 neurotrophin 3
NTF4 neurotrophin 4
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
NTS neurotensin
NTSR1 neurotensin receptor 1 (high affinity)
NTSR2 neurotensin receptor 2
OPRD1 opioid receptor, delta 1
OPRK1 opioid receptor, kappa 1
OPRM1 opioid receptor, mu 1
OSM oncostatin M
OTX1 orthodenticle homeobox 1
OXT oxytocin/neurophysin I prepropeptide
OXTR oxytocin receptor
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PAH phenylalanine hydroxylase
PARK2 parkin RBR E3 ubiquitin protein ligase
PCNT pericentrin
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4D phosphodiesterase 4D, cAMP-specific
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PDYN prodynorphin
PENK proenkephalin
PHF8 PHD finger protein 8
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha
PICK1 protein interacting with PRKCA 1
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLCB4 phospholipase C, beta 4
PLCD1 phospholipase C, delta 1
PLCD4 phospholipase C, delta 4
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLD1 phospholipase D1, phosphatidylcholine-specific
PLD2 phospholipase D2
PMCH pro-melanin-concentrating hormone
PNMT phenylethanolamine N-methyltransferase
POMC proopiomelanocortin
PPARG peroxisome proliferator-activated receptor gamma
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme
PREB prolactin regulatory element binding
PRKCA protein kinase C, alpha
PRL prolactin
PRLR prolactin receptor
PRODH proline dehydrogenase (oxidase) 1
PTN pleiotrophin
PYY peptide YY
RAB2A RAB2A, member RAS oncogene family
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RARA retinoic acid receptor, alpha
RARB retinoic acid receptor, beta
RARG retinoic acid receptor, gamma
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2
RELN reelin
RGS2 regulator of G-protein signaling 2
RORA RAR-related orphan receptor A
RTN4R reticulon 4 receptor
RXRA retinoid X receptor, alpha
RXRB retinoid X receptor, beta
RXRG retinoid X receptor, gamma
S100B S100 calcium binding protein B
SAT1 spermidine/spermine N1-acetyltransferase 1
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SCT secretin
SDC2 syndecan 2
SDK1 sidekick cell adhesion molecule 1
SERINC2 serine incorporator 2
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SHBG sex hormone-binding globulin
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC38A1 solute carrier family 38, member 1
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SLITRK1 SLIT and NTRK-like family, member 1
SLTM SAFB-like, transcription modulator
SNAP23 synaptosomal-associated protein, 23kDa
SNAP25 synaptosomal-associated protein, 25kDa
SNAP29 synaptosomal-associated protein, 29kDa
SNAP91 synaptosomal-associated protein, 91kDa
SOD2 superoxide dismutase 2, mitochondrial
SST somatostatin
SSTR1 somatostatin receptor 1
SSTR2 somatostatin receptor 2
SSTR3 somatostatin receptor 3
SSTR4 somatostatin receptor 4
SSTR5 somatostatin receptor 5
SYN1 synapsin I
TAC1 tachykinin, precursor 1
TAC3 tachykinin 3
TACR1 tachykinin receptor 1
TACR2 tachykinin receptor 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFIP11 tuftelin interacting protein 11
TGFB1 transforming growth factor, beta 1
TH tyrosine hydroxylase
TNF tumor necrosis factor
TPH1 tryptophan hydroxylase 1
TPH2 tryptophan hydroxylase 2
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRH thyrotropin-releasing hormone
TRHR thyrotropin-releasing hormone receptor
TSC2 tuberous sclerosis 2
TSNAX translin-associated factor X
TSNAX-DISC1 TSNAX-DISC1 readthrough (NMD candidate)
TUBA1A tubulin, alpha 1a
UBE3A ubiquitin protein ligase E3A
UCN urocortin
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VIP vasoactive intestinal peptide
VIPR1 vasoactive intestinal peptide receptor 1
VIPR2 vasoactive intestinal peptide receptor 2
WNK3 WNK lysine deficient protein kinase 3
ZNF804A zinc finger protein 804A