Meningococcal Infections Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Infections with bacteria of the species NEISSERIA MENINGITIDIS. (Experimental Factor Ontology, EFO_0004249)
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Genes

165 genes associated with the Meningococcal Infections phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ADD1 adducin 1 (alpha)
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AICDA activation-induced cytidine deaminase
AKT1 v-akt murine thymoma viral oncogene homolog 1
BAG6 BCL2-associated athanogene 6
BCL6 B-cell CLL/lymphoma 6
BTK Bruton agammaglobulinemia tyrosine kinase
C3 complement component 3
C6 complement component 6
CARD8 caspase recruitment domain family, member 8
CCHCR1 coiled-coil alpha-helical rod protein 1
CD14 CD14 molecule
CD163 CD163 molecule
CD22 CD22 molecule
CD28 CD28 molecule
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD5 CD5 molecule
CD58 CD58 molecule
CD69 CD69 molecule
CD70 CD70 molecule
CD80 CD80 molecule
CD86 CD86 molecule
CDC42 cell division cycle 42
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFH complement factor H
CFHR3 complement factor H-related 3
CIITA class II, major histocompatibility complex, transactivator
CISH cytokine inducible SH2-containing protein
CLEC7A C-type lectin domain family 7, member A
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRP C-reactive protein, pentraxin-related
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CXCR5 chemokine (C-X-C motif) receptor 5
DCPS decapping enzyme, scavenger
DEFA4 defensin, alpha 4, corticostatin
DEFB1 defensin, beta 1
DEXI Dexi homolog (mouse)
FAS Fas cell surface death receptor
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FOXRED1 FAD-dependent oxidoreductase domain containing 1
GATA3 GATA binding protein 3
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GPNMB glycoprotein (transmembrane) nmb
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
ICOS inducible T-cell co-stimulator
ICOSLG inducible T-cell co-stimulator ligand
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IFNL1 interferon, lambda 1
IFNL3 interferon, lambda 3
IFNLR1 interferon, lambda receptor 1
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL10RB interleukin 10 receptor, beta
IL12RB1 interleukin 12 receptor, beta 1
IL12RB2 interleukin 12 receptor, beta 2
IL15 interleukin 15
IL15RA interleukin 15 receptor, alpha
IL19 interleukin 19
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
IL1RL1 interleukin 1 receptor-like 1
IL1RL2 interleukin 1 receptor-like 2
IL1RN interleukin 1 receptor antagonist
IL22 interleukin 22
IL22RA1 interleukin 22 receptor, alpha 1
IL22RA2 interleukin 22 receptor, alpha 2
IL26 interleukin 26
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
IL7 interleukin 7
IL7R interleukin 7 receptor
IRAK3 interleukin-1 receptor-associated kinase 3
IRAK4 interleukin-1 receptor-associated kinase 4
IRF1 interferon regulatory factor 1
IRF4 interferon regulatory factor 4
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAK1 Janus kinase 1
JAK3 Janus kinase 3
LGMN legumain
LST1 leukocyte specific transcript 1
LTA lymphotoxin alpha
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K6 mitogen-activated protein kinase kinase 6
MAPK8 mitogen-activated protein kinase 8
MBL2 mannose-binding lectin (protein C) 2, soluble
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MX1 MX dynamin-like GTPase 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOTCH4 notch 4
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PARP1 poly (ADP-ribose) polymerase 1
PAX5 paired box 5
PRDM1 PR domain containing 1, with ZNF domain
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RANGAP1 Ran GTPase activating protein 1
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RFXAP regulatory factor X-associated protein
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFTPD surfactant protein D
SPI1 Spi-1 proto-oncogene
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
TBX21 T-box 21
TGFB1 transforming growth factor, beta 1
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TMEM37 transmembrane protein 37
TNF tumor necrosis factor
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8
TOLLIP toll interacting protein
TONSL tonsoku-like, DNA repair protein
TRAF3 TNF receptor-associated factor 3
TRAF5 TNF receptor-associated factor 5
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
WDR27 WD repeat domain 27
XBP1 X-box binding protein 1
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa