MS-275-7084 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the MS-275-7084 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD6 abhydrolase domain containing 6
ABLIM1 actin binding LIM protein 1
ADGRF5 adhesion G protein-coupled receptor F5
AHR aryl hydrocarbon receptor
ANGPTL4 angiopoietin-like 4
APOLD1 apolipoprotein L domain containing 1
AQP3 aquaporin 3 (Gill blood group)
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL14 ADP-ribosylation factor-like 14
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATXN1 ataxin 1
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BCL6 B-cell CLL/lymphoma 6
BMP6 bone morphogenetic protein 6
CCDC68 coiled-coil domain containing 68
CCNA1 cyclin A1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLU clusterin
CPA4 carboxypeptidase A4
CPM carboxypeptidase M
CREB5 cAMP responsive element binding protein 5
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTGF connective tissue growth factor
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DENND3 DENN/MADD domain containing 3
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFNB2 ephrin-B2
EGR2 early growth response 2
ELOVL6 ELOVL fatty acid elongase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA4 EPH receptor A4
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP4 fatty acid binding protein 4, adipocyte
FGF13 fibroblast growth factor 13
FLRT3 fibronectin leucine rich transmembrane protein 3
FYB FYN binding protein
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPA2 heat shock 70kDa protein 2
IL11 interleukin 11
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R2 interleukin 1 receptor, type II
IL1RAP interleukin 1 receptor accessory protein
IL1RL1 interleukin 1 receptor-like 1
IL1RN interleukin 1 receptor antagonist
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LIPG lipase, endothelial
LMCD1 LIM and cysteine-rich domains 1
LPPR4 lipid phosphate phosphatase-related protein type 4
MEF2C myocyte enhancer factor 2C
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP13 matrix metallopeptidase 13
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
MYLK myosin light chain kinase
NAV3 neuron navigator 3
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NKX3-1 NK3 homeobox 1
PDE4B phosphodiesterase 4B, cAMP-specific
PLK2 polo-like kinase 2
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGCC regulator of cell cycle
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS17 regulator of G-protein signaling 17
RGS4 regulator of G-protein signaling 4
RGS7 regulator of G-protein signaling 7
RHOB ras homolog family member B
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SETBP1 SET binding protein 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STC1 stanniocalcin 1
STOM stomatin
SYBU syntabulin (syntaxin-interacting)
TAGLN3 transgelin 3
THBS1 thrombospondin 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TRIM29 tripartite motif containing 29
TUBAL3 tubulin, alpha-like 3
TUFT1 tuftelin 1

decreased expression

Symbol Name
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARHGAP11A Rho GTPase activating protein 11A
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ATAD2B ATPase family, AAA domain containing 2B
BCAS3 breast carcinoma amplified sequence 3
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BRPF1 bromodomain and PHD finger containing, 1
C1ORF27 chromosome 1 open reading frame 27
CCDC28A coiled-coil domain containing 28A
CDCA3 cell division cycle associated 3
CLCF1 cardiotrophin-like cytokine factor 1
CNN2 calponin 2
CNTNAP1 contactin associated protein 1
COG7 component of oligomeric golgi complex 7
CRBN cereblon
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CTCF CCCTC-binding factor (zinc finger protein)
CXORF40A chromosome X open reading frame 40A
CXORF40B chromosome X open reading frame 40B
DCBLD2 discoidin, CUB and LCCL domain containing 2
DCLRE1A DNA cross-link repair 1A
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
DOLK dolichol kinase
DOLPP1 dolichyldiphosphatase 1
DPH2 DPH2 homolog (S. cerevisiae)
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
E4F1 E4F transcription factor 1
EXOC3 exocyst complex component 3
EXOC5 exocyst complex component 5
FKBPL FK506 binding protein like
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GRPR gastrin-releasing peptide receptor
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
HINFP histone H4 transcription factor
HIRA histone cell cycle regulator
HIST1H2BI histone cluster 1, H2bi
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
KCTD7 potassium channel tetramerization domain containing 7
KDM4A lysine (K)-specific demethylase 4A
KEAP1 kelch-like ECH-associated protein 1
KIAA0753 KIAA0753
KLHL21 kelch-like family member 21
KLHL26 kelch-like family member 26
LIAS lipoic acid synthetase
MCM10 minichromosome maintenance complex component 10
MCOLN1 mucolipin 1
NECAB3 N-terminal EF-hand calcium binding protein 3
NEU1 sialidase 1 (lysosomal sialidase)
NPM3 nucleophosmin/nucleoplasmin 3
NXF1 nuclear RNA export factor 1
ORC1 origin recognition complex, subunit 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PIAS3 protein inhibitor of activated STAT, 3
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLK1 polo-like kinase 1
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R8 protein phosphatase 1, regulatory subunit 8
PPP2R2D protein phosphatase 2, regulatory subunit B, delta
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PSENEN presenilin enhancer gamma secretase subunit
PTGFR prostaglandin F receptor (FP)
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
RAD54L RAD54-like (S. cerevisiae)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM42 RNA binding motif protein 42
SAP130 Sin3A-associated protein, 130kDa
SAP30L SAP30-like
SCYL2 SCY1-like 2 (S. cerevisiae)
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC25A38 solute carrier family 25, member 38
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMAGP small cell adhesion glycoprotein
SMTN smoothelin
STK16 serine/threonine kinase 16
STX4 syntaxin 4
STX5 syntaxin 5
SUOX sulfite oxidase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I
TESK1 testis-specific kinase 1
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TLK2 tousled-like kinase 2
TMEM115 transmembrane protein 115
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOE1 target of EGR1, member 1 (nuclear)
TRAPPC12 trafficking protein particle complex 12
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TSSC4 tumor suppressing subtransferable candidate 4
UBE2M ubiquitin-conjugating enzyme E2M
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
ZCCHC8 zinc finger, CCHC domain containing 8
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZNF124 zinc finger protein 124
ZNF263 zinc finger protein 263
ZNF282 zinc finger protein 282
ZNF586 zinc finger protein 586