MS-275-7074 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the MS-275-7074 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADGRF5 adhesion G protein-coupled receptor F5
AKR1C1 aldo-keto reductase family 1, member C1
ANGPTL4 angiopoietin-like 4
APOLD1 apolipoprotein L domain containing 1
AQP3 aquaporin 3 (Gill blood group)
ARL14 ADP-ribosylation factor-like 14
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
BMP6 bone morphogenetic protein 6
C1ORF116 chromosome 1 open reading frame 116
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN1 claudin 1
CLU clusterin
CPA4 carboxypeptidase A4
CPM carboxypeptidase M
CREB3L1 cAMP responsive element binding protein 3-like 1
CTGF connective tissue growth factor
CXCL5 chemokine (C-X-C motif) ligand 5
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ELOVL6 ELOVL fatty acid elongase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP4 fatty acid binding protein 4, adipocyte
FGD6 FYVE, RhoGEF and PH domain containing 6
FGFBP1 fibroblast growth factor binding protein 1
FLRT3 fibronectin leucine rich transmembrane protein 3
FYB FYN binding protein
GEM GTP binding protein overexpressed in skeletal muscle
GRB10 growth factor receptor-bound protein 10
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPA2 heat shock 70kDa protein 2
IL11 interleukin 11
IL1B interleukin 1, beta
IL1R2 interleukin 1 receptor, type II
IL1RL1 interleukin 1 receptor-like 1
IL1RN interleukin 1 receptor antagonist
IL24 interleukin 24
IRS2 insulin receptor substrate 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT37 keratin 37, type I
KRT6A keratin 6A, type II
KYNU kynureninase
LIPG lipase, endothelial
LMCD1 LIM and cysteine-rich domains 1
LOC157562 uncharacterized LOC157562
LPPR4 lipid phosphate phosphatase-related protein type 4
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP13 matrix metallopeptidase 13
MMP16 matrix metallopeptidase 16 (membrane-inserted)
NAV3 neuron navigator 3
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NGF nerve growth factor (beta polypeptide)
NOV nephroblastoma overexpressed
PCDH7 protocadherin 7
PDE4B phosphodiesterase 4B, cAMP-specific
PLAC1 placenta-specific 1
PLK2 polo-like kinase 2
PPL periplakin
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB31 RAB31, member RAS oncogene family
RAP1GAP2 RAP1 GTPase activating protein 2
RGS17 regulator of G-protein signaling 17
RGS4 regulator of G-protein signaling 4
RGS7 regulator of G-protein signaling 7
RHOB ras homolog family member B
SCEL sciellin
SCG5 secretogranin V
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH2D2A SH2 domain containing 2A
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAT4 signal transducer and activator of transcription 4
STC1 stanniocalcin 1
STOM stomatin
TAGLN3 transgelin 3
TMEM2 transmembrane protein 2
TNC tenascin C
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TRIM29 tripartite motif containing 29
TRIM9 tripartite motif containing 9
TUBAL3 tubulin, alpha-like 3
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1

decreased expression

Symbol Name
ANKZF1 ankyrin repeat and zinc finger domain containing 1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APH1A APH1A gamma secretase subunit
ATAD2B ATPase family, AAA domain containing 2B
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
AXIN1 axin 1
BARD1 BRCA1 associated RING domain 1
BAX BCL2-associated X protein
BCL7A B-cell CLL/lymphoma 7A
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BRPF1 bromodomain and PHD finger containing, 1
C11ORF30 chromosome 11 open reading frame 30
CCDC6 coiled-coil domain containing 6
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CIR1 corepressor interacting with RBPJ, 1
CLCF1 cardiotrophin-like cytokine factor 1
COA7 cytochrome c oxidase assembly factor 7 (putative)
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
CRY2 cryptochrome circadian clock 2
CTCF CCCTC-binding factor (zinc finger protein)
DEPDC1 DEP domain containing 1
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
ERF Ets2 repressor factor
EYA4 EYA transcriptional coactivator and phosphatase 4
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GBX2 gastrulation brain homeobox 2
GPHN gephyrin
GPRC5C G protein-coupled receptor, class C, group 5, member C
GRPR gastrin-releasing peptide receptor
HIRA histone cell cycle regulator
HMOX1 heme oxygenase 1
HOXA10 homeobox A10
INHBB inhibin, beta B
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
ITPKB inositol-trisphosphate 3-kinase B
KIAA0355 KIAA0355
KIAA0753 KIAA0753
KIFC1 kinesin family member C1
LMNB1 lamin B1
LRRC37A3 leucine rich repeat containing 37, member A3
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGOH mago-nashi homolog, proliferation-associated (Drosophila)
MICALL2 MICAL-like 2
MNT MAX network transcriptional repressor
MON1B MON1 secretory trafficking family member B
MSL2 male-specific lethal 2 homolog (Drosophila)
MXD3 MAX dimerization protein 3
NR2C2 nuclear receptor subfamily 2, group C, member 2
NXF1 nuclear RNA export factor 1
ORC1 origin recognition complex, subunit 1
ORC2 origin recognition complex, subunit 2
PCNT pericentrin
PEX11B peroxisomal biogenesis factor 11 beta
PEX26 peroxisomal biogenesis factor 26
PFDN6 prefoldin subunit 6
PLA2G15 phospholipase A2, group XV
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
PPP2R2D protein phosphatase 2, regulatory subunit B, delta
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PSENEN presenilin enhancer gamma secretase subunit
RAD54L RAD54-like (S. cerevisiae)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM41 RNA binding motif protein 41
RCOR3 REST corepressor 3
RFWD3 ring finger and WD repeat domain 3
RNF121 ring finger protein 121
SAP130 Sin3A-associated protein, 130kDa
SCO2 SCO2 cytochrome c oxidase assembly protein
SCYL2 SCY1-like 2 (S. cerevisiae)
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC25A38 solute carrier family 25, member 38
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SMAGP small cell adhesion glycoprotein
SNX15 sorting nexin 15
SPATA2L spermatogenesis associated 2-like
STK16 serine/threonine kinase 16
SUOX sulfite oxidase
SYNE2 spectrin repeat containing, nuclear envelope 2
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TBC1D12 TBC1 domain family, member 12
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TMEM194A transmembrane protein 194A
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRAPPC12 trafficking protein particle complex 12
TROAP trophinin associated protein
UBTF upstream binding transcription factor, RNA polymerase I
UNKL unkempt family zinc finger-like
WDR19 WD repeat domain 19
WDR76 WD repeat domain 76
YIPF5 Yip1 domain family, member 5
ZC3H3 zinc finger CCCH-type containing 3
ZNF324 zinc finger protein 324
ZNF394 zinc finger protein 394
ZNF696 zinc finger protein 696