MK-886-601 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the MK-886-601 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACVR1B activin A receptor, type IB
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
AQP3 aquaporin 3 (Gill blood group)
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
ARNT aryl hydrocarbon receptor nuclear translocator
ATXN8OS ATXN8 opposite strand (non-protein coding)
BAX BCL2-associated X protein
BICD1 bicaudal D homolog 1 (Drosophila)
BRAP BRCA1 associated protein
C10ORF76 chromosome 10 open reading frame 76
C9ORF156 chromosome 9 open reading frame 156
CCDC87 coiled-coil domain containing 87
CD86 CD86 molecule
CLIC4 chloride intracellular channel 4
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CNOT4 CCR4-NOT transcription complex, subunit 4
CNTFR ciliary neurotrophic factor receptor
CRHR2 corticotropin releasing hormone receptor 2
CRYAB crystallin, alpha B
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7
DLK2 delta-like 2 homolog (Drosophila)
DTX3 deltex 3, E3 ubiquitin ligase
ENG endoglin
ERCC4 excision repair cross-complementation group 4
GADD45B growth arrest and DNA-damage-inducible, beta
GPATCH4 G patch domain containing 4
GREB1L growth regulation by estrogen in breast cancer-like
HIPK2 homeodomain interacting protein kinase 2
HLA-G major histocompatibility complex, class I, G
HMX1 H6 family homeobox 1
ICAM1 intercellular adhesion molecule 1
IL1B interleukin 1, beta
IL2RG interleukin 2 receptor, gamma
IL7R interleukin 7 receptor
KLHL28 kelch-like family member 28
LARP6 La ribonucleoprotein domain family, member 6
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LOC647070 uncharacterized LOC647070
MAN1C1 mannosidase, alpha, class 1C, member 1
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAPK1 mitogen-activated protein kinase 1
MAX MYC associated factor X
MED28 mediator complex subunit 28
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MPPED1 metallophosphoesterase domain containing 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYH7 myosin, heavy chain 7, cardiac muscle, beta
NACA nascent polypeptide-associated complex alpha subunit
NF1 neurofibromin 1
NNAT neuronatin
NOS1 nitric oxide synthase 1 (neuronal)
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRGN neurogranin (protein kinase C substrate, RC3)
PEX11A peroxisomal biogenesis factor 11 alpha
PHF20 PHD finger protein 20
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PKNOX2 PBX/knotted 1 homeobox 2
PLXNB1 plexin B1
PRELP proline/arginine-rich end leucine-rich repeat protein
PRKCA protein kinase C, alpha
RAB11B RAB11B, member RAS oncogene family
RORC RAR-related orphan receptor C
RPS2 ribosomal protein S2
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RSL1D1 ribosomal L1 domain containing 1
SDC2 syndecan 2
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SH3BP2 SH3-domain binding protein 2
SLA Src-like-adaptor
SLC43A3 solute carrier family 43, member 3
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SPDEF SAM pointed domain containing ETS transcription factor
SPIN2A spindlin family, member 2A
SPRR1B small proline-rich protein 1B
SUGP2 SURP and G patch domain containing 2
SUSD4 sushi domain containing 4
SVIL supervillin
SYT17 synaptotagmin XVII
T T, brachyury homolog (mouse)
TBX21 T-box 21
TSPAN32 tetraspanin 32
TUBA4B tubulin, alpha 4b
USP34 ubiquitin specific peptidase 34
WDR48 WD repeat domain 48
XYLT2 xylosyltransferase II
ZBED1 zinc finger, BED-type containing 1
ZC3H12A zinc finger CCCH-type containing 12A
ZCCHC24 zinc finger, CCHC domain containing 24
ZMYM6 zinc finger, MYM-type 6
ZNF250 zinc finger protein 250
ZNF473 zinc finger protein 473
ZNF589 zinc finger protein 589
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4
ACSL5 acyl-CoA synthetase long-chain family member 5
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6
ADM2 adrenomedullin 2
AHR aryl hydrocarbon receptor
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALLC allantoicase
AMT aminomethyltransferase
AURKC aurora kinase C
AXIN1 axin 1
BATF3 basic leucine zipper transcription factor, ATF-like 3
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2L14 BCL2-like 14 (apoptosis facilitator)
BEAN1 brain expressed, associated with NEDD4, 1
BEX1 brain expressed, X-linked 1
BNC1 basonuclin 1
BTNL3 butyrophilin-like 3
C4BPA complement component 4 binding protein, alpha
CAV3 caveolin 3
CCDC71 coiled-coil domain containing 71
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CENPQ centromere protein Q
COBL cordon-bleu WH2 repeat protein
COPZ2 coatomer protein complex, subunit zeta 2
CPB1 carboxypeptidase B1 (tissue)
CRIPT cysteine-rich PDZ-binding protein
CSN2 casein beta
CTSK cathepsin K
DLK1 delta-like 1 homolog (Drosophila)
EDA2R ectodysplasin A2 receptor
EGFL7 EGF-like-domain, multiple 7
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EMILIN2 elastin microfibril interfacer 2
ERN2 endoplasmic reticulum to nucleus signaling 2
F13A1 coagulation factor XIII, A1 polypeptide
FAM188A family with sequence similarity 188, member A
FAM214B family with sequence similarity 214, member B
FAM76A family with sequence similarity 76, member A
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXO2 F-box protein 2
FOXD1 forkhead box D1
GJC1 gap junction protein, gamma 1, 45kDa
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HBD hemoglobin, delta
HHLA1 HERV-H LTR-associating 1
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular)
INA internexin neuronal intermediate filament protein, alpha
IRF2 interferon regulatory factor 2
KIFC3 kinesin family member C3
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
LINC00574 long intergenic non-protein coding RNA 574
LPPR1 lipid phosphate phosphatase-related protein type 1
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3
LRP3 low density lipoprotein receptor-related protein 3
LRRC15 leucine rich repeat containing 15
MAP2 microtubule-associated protein 2
MMP2 matrix metallopeptidase 2
MT3 metallothionein 3
MVP major vault protein
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
PDE8B phosphodiesterase 8B
PFAS phosphoribosylformylglycinamidine synthase
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PRODH2 proline dehydrogenase (oxidase) 2
PRRX1 paired related homeobox 1
PTDSS2 phosphatidylserine synthase 2
RASIP1 Ras interacting protein 1
RELN reelin
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila)
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
RPS4Y1 ribosomal protein S4, Y-linked 1
SHARPIN SHANK-associated RH domain interactor
SND1-IT1 SND1 intronic transcript 1
SRPX sushi-repeat containing protein, X-linked
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TINAGL1 tubulointerstitial nephritis antigen-like 1
TMEM206 transmembrane protein 206
TMEM39A transmembrane protein 39A
TNS2 tensin 2
TOR4A torsin family 4, member A
TRIM8 tripartite motif containing 8
UBQLN4 ubiquilin 4
ULBP1 UL16 binding protein 1
VIPR1 vasoactive intestinal peptide receptor 1
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WDR19 WD repeat domain 19
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBED2 zinc finger, BED-type containing 2
ZBTB22 zinc finger and BTB domain containing 22
ZCCHC2 zinc finger, CCHC domain containing 2
ZNF134 zinc finger protein 134
ZNF34 zinc finger protein 34
ZNF770 zinc finger protein 770
ZNF816 zinc finger protein 816