MG-262-7063 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the MG-262-7063 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ABHD4 abhydrolase domain containing 4
AEN apoptosis enhancing nuclease
AKR1C1 aldo-keto reductase family 1, member C1
ANKRD11 ankyrin repeat domain 11
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BIN1 bridging integrator 1
BMP7 bone morphogenetic protein 7
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CARS cysteinyl-tRNA synthetase
CCNT2 cyclin T2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CREM cAMP responsive element modulator
CRY2 cryptochrome circadian clock 2
CSRP2 cysteine and glycine-rich protein 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV5 ets variant 5
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
FERMT2 fermitin family member 2
FHL1 four and a half LIM domains 1
FLOT1 flotillin 1
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
FSCN1 fascin actin-bundling protein 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GOSR2 golgi SNAP receptor complex member 2
GRB10 growth factor receptor-bound protein 10
HBEGF heparin-binding EGF-like growth factor
HMOX1 heme oxygenase 1
HRK harakiri, BCL2 interacting protein
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL15RA interleukin 15 receptor, alpha
INHBE inhibin, beta E
JUN jun proto-oncogene
LARP6 La ribonucleoprotein domain family, member 6
LINC00260 long intergenic non-protein coding RNA 260
LPIN1 lipin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MMP19 matrix metallopeptidase 19
N4BP2L2 NEDD4 binding protein 2-like 2
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
OSGIN1 oxidative stress induced growth inhibitor 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDLIM5 PDZ and LIM domain 5
PGF placental growth factor
PLK3 polo-like kinase 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PVT1 Pvt1 oncogene (non-protein coding)
REEP1 receptor accessory protein 1
RGS2 regulator of G-protein signaling 2
RND1 Rho family GTPase 1
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3BGR SH3 domain binding glutamate-rich protein
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A7 solute carrier family 38, member 7
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SNAI2 snail family zinc finger 2
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome)
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
STYK1 serine/threonine/tyrosine kinase 1
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TES testin LIM domain protein
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TSPYL2 TSPY-like 2
UBB ubiquitin B
VEGFA vascular endothelial growth factor A
WDR33 WD repeat domain 33
ZFP69B ZFP69 zinc finger protein B
ZNF473 zinc finger protein 473

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ACYP1 acylphosphatase 1, erythrocyte (common) type
AGR2 anterior gradient 2
AMD1 adenosylmethionine decarboxylase 1
ARID5B AT rich interactive domain 5B (MRF1-like)
BACE1 beta-site APP-cleaving enzyme 1
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C1GALT1C1 C1GALT1-specific chaperone 1
C9ORF40 chromosome 9 open reading frame 40
CA2 carbonic anhydrase II
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CAMTA2 calmodulin binding transcription activator 2
CCNE2 cyclin E2
CD302 CD302 molecule
CD9 CD9 molecule
CENPB centromere protein B, 80kDa
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COA3 cytochrome c oxidase assembly factor 3
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CXCL12 chemokine (C-X-C motif) ligand 12
DKK1 dickkopf WNT signaling pathway inhibitor 1
E2F8 E2F transcription factor 8
EFCAB2 EF-hand calcium binding domain 2
EFNA1 ephrin-A1
EGR3 early growth response 3
EMC9 ER membrane protein complex subunit 9
EMP2 epithelial membrane protein 2
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERCC6L excision repair cross-complementation group 6-like
ETAA1 Ewing tumor-associated antigen 1
FADS2 fatty acid desaturase 2
FAM111A family with sequence similarity 111, member A
FAM127A family with sequence similarity 127, member A
FAM127B family with sequence similarity 127, member B
FBXL15 F-box and leucine-rich repeat protein 15
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FOXD1 forkhead box D1
GALE UDP-galactose-4-epimerase
GJA1 gap junction protein, alpha 1, 43kDa
GPR19 G protein-coupled receptor 19
GTF2H5 general transcription factor IIH, polypeptide 5
H1FX H1 histone family, member X
H2BFS H2B histone family, member S (pseudogene)
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AG histone cluster 1, H2ag
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
HOXC6 homeobox C6
IRX5 iroquois homeobox 5
LINC00115 long intergenic non-protein coding RNA 115
LOC730101 uncharacterized LOC730101
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
MAGOHB mago-nashi homolog B (Drosophila)
MAN1A1 mannosidase, alpha, class 1A, member 1
MANEA mannosidase, endo-alpha
MFSD5 major facilitator superfamily domain containing 5
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MXD3 MAX dimerization protein 3
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
NME5 NME/NM23 family member 5
NPY1R neuropeptide Y receptor Y1
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRGN neurogranin (protein kinase C substrate, RC3)
OPN3 opsin 3
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PARD6A par-6 family cell polarity regulator alpha
PCNA proliferating cell nuclear antigen
PEX11B peroxisomal biogenesis factor 11 beta
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PP14571 uncharacterized LOC100130449
PSRC1 proline/serine-rich coiled-coil 1
RECQL4 RecQ protein-like 4
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SLC35A5 solute carrier family 35, member A5
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SPINK4 serine peptidase inhibitor, Kazal type 4
STARD13 StAR-related lipid transfer (START) domain containing 13
SULF1 sulfatase 1
TMEM120B transmembrane protein 120B
TMEM187 transmembrane protein 187
TMEM251 transmembrane protein 251
TPBG trophoblast glycoprotein
WDR25 WD repeat domain 25
WEE1 WEE1 G2 checkpoint kinase
XYLT2 xylosyltransferase II
ZBED8 zinc finger, BED-type containing 8
ZMYM3 zinc finger, MYM-type 3
ZNF324 zinc finger protein 324
ZNF606 zinc finger protein 606