Lymphatic Metastasis Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

240 genes associated with the Lymphatic Metastasis phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACE angiotensin I converting enzyme
AGTR2 angiotensin II receptor, type 2
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALK anaplastic lymphoma receptor tyrosine kinase
APC adenomatous polyposis coli
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARNT aryl hydrocarbon receptor nuclear translocator
ATM ATM serine/threonine kinase
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BID BH3 interacting domain death agonist
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC5 baculoviral IAP repeat containing 5
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRMS1 breast cancer metastasis suppressor 1
C1QA complement component 1, q subcomponent, A chain
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CCR2 chemokine (C-C motif) receptor 2
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CELF4 CUGBP, Elav-like family member 4
CHEK2 checkpoint kinase 2
CLDN1 claudin 1
CLDN7 claudin 7
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
CRP C-reactive protein, pentraxin-related
CTBP2 C-terminal binding protein 2
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DLX4 distal-less homeobox 4
EEFSEC eukaryotic elongation factor, selenocysteine-tRNA-specific
EFNA1 ephrin-A1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EHBP1 EH domain binding protein 1
EPHB4 EPH receptor B4
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC5 excision repair cross-complementation group 5
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR4 fibroblast growth factor receptor 4
FHIT fragile histidine triad
FOXE1 forkhead box E1
FUT2 fucosyltransferase 2 (secretor status included)
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-G major histocompatibility complex, class I, G
HMOX1 heme oxygenase 1
HPSE heparanase
HRAS Harvey rat sarcoma viral oncogene homolog
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HYAL3 hyaluronoglucosaminidase 3
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IL10 interleukin 10
IL12B interleukin 12B
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
IL6R interleukin 6 receptor
INHBC inhibin, beta C
IQGAP1 IQ motif containing GTPase activating protein 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA6 integrin, alpha 6
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAZF1 JAZF zinc finger 1
KDR kinase insert domain receptor
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLK3 kallikrein-related peptidase 3
KRAS Kirsten rat sarcoma viral oncogene homolog
LACC1 laccase (multicopper oxidoreductase) domain containing 1
LIG4 ligase IV, DNA, ATP-dependent
LMTK2 lemur tyrosine kinase 2
LSP1 lymphocyte-specific protein 1
LTA lymphotoxin alpha
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED12 mediator complex subunit 12
MFSD2A major facilitator superfamily domain containing 2A
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR146A microRNA 146a
MIR155 microRNA 155
MIR196A2 microRNA 196a-2
MIR21 microRNA 21
MIR27A microRNA 27a
MLH1 mutL homolog 1
MMP1 matrix metallopeptidase 1
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MSMB microseminoprotein, beta-
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUS81 MUS81 structure-specific endonuclease subunit
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NBN nibrin
NEIL1 nei endonuclease VIII-like 1 (E. coli)
NEIL2 nei endonuclease VIII-like 2 (E. coli)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NKX2-1 NK2 homeobox 1
NKX3-1 NK3 homeobox 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NR1I2 nuclear receptor subfamily 1, group I, member 2
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRP1 neuropilin 1
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OGG1 8-oxoguanine DNA glycosylase
PALB2 partner and localizer of BRCA2
PARP1 poly (ADP-ribose) polymerase 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PGR progesterone receptor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
POLB polymerase (DNA directed), beta
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POPDC3 popeye domain containing 3
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A
PPP1R3A protein phosphatase 1, regulatory subunit 3A
PSCA prostate stem cell antigen
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PWAR1 Prader Willi/Angelman region RNA 1
RAD51 RAD51 recombinase
RAP1A RAP1A, member of RAS oncogene family
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RET ret proto-oncogene
RFC1 replication factor C (activator 1) 1, 145kDa
RIPK2 receptor-interacting serine-threonine kinase 2
RRP1B ribosomal RNA processing 1B
RUNX1 runt-related transcription factor 1
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIPA1 signal-induced proliferation-associated 1
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMAD6 SMAD family member 6
SOD2 superoxide dismutase 2, mitochondrial
SPP1 secreted phosphoprotein 1
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
STK11 serine/threonine kinase 11
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TCF20 transcription factor 20 (AR1)
TGFB1 transforming growth factor, beta 1
THADA thyroid adenoma associated
THBS1 thrombospondin 1
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR10 toll-like receptor 10
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR8 toll-like receptor 8
TLR9 toll-like receptor 9
TMC8 transmembrane channel-like 8
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TOP2A topoisomerase (DNA) II alpha 170kDa
TOPBP1 topoisomerase (DNA) II binding protein 1
TOX3 TOX high mobility group box family member 3
TP53 tumor protein p53
TRIT1 tRNA isopentenyltransferase 1
TYMS thymidylate synthetase
UBE2I ubiquitin-conjugating enzyme E2I
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UQCRB ubiquinol-cytochrome c reductase binding protein
VCP valosin containing protein
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
XAF1 XIAP associated factor 1
XPC xeroderma pigmentosum, complementation group C
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3