Lupus Nephritis Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982). (Experimental Factor Ontology, EFO_0005761)
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Genes

99 genes associated with the Lupus Nephritis phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACE angiotensin I converting enzyme
ACTN4 actinin, alpha 4
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
APOH apolipoprotein H (beta-2-glycoprotein I)
APOL1 apolipoprotein L, 1
APOL3 apolipoprotein L, 3
BANK1 B-cell scaffold protein with ankyrin repeats 1
BLK BLK proto-oncogene, Src family tyrosine kinase
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C1QC complement component 1, q subcomponent, C chain
C5 complement component 5
CARD11 caspase recruitment domain family, member 11
CCL2 chemokine (C-C motif) ligand 2
CCL3L1 chemokine (C-C motif) ligand 3-like 1
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD244 CD244 molecule, natural killer cell receptor 2B4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CRP C-reactive protein, pentraxin-related
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DNASE1 deoxyribonuclease I
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGB fibrinogen beta chain
HAS2 hyaluronan synthase 2
HCG27 HLA complex group 27 (non-protein coding)
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL10 interleukin 10
IL12B interleukin 12B
IL12RB1 interleukin 12 receptor, beta 1
IL18 interleukin 18
IL1RN interleukin 1 receptor antagonist
IL21 interleukin 21
IRAK1 interleukin-1 receptor-associated kinase 1
IRF5 interferon regulatory factor 5
IRF7 interferon regulatory factor 7
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KLK1 kallikrein 1
LMAN1 lectin, mannose-binding, 1
LTA lymphotoxin alpha
MBL2 mannose-binding lectin (protein C) 2, soluble
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MECP2 methyl CpG binding protein 2
MSH5 mutS homolog 5
MTMR3 myotubularin related protein 3
MYH9 myosin, heavy chain 9, non-muscle
NFE2L2 nuclear factor, erythroid 2-like 2
NOS3 nitric oxide synthase 3 (endothelial cell)
OAZ1 ornithine decarboxylase antizyme 1
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PARP1 poly (ADP-ribose) polymerase 1
PDCD1 programmed cell death 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHRF1 PHD and ring finger domains 1
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
PON1 paraoxonase 1
PON3 paraoxonase 3
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PXK PX domain containing serine/threonine kinase
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SPP1 secreted phosphoprotein 1
STAT4 signal transducer and activator of transcription 4
TGFB1 transforming growth factor, beta 1
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNIP1 TNFAIP3 interacting protein 1
TP53 tumor protein p53
TRAF1 TNF receptor-associated factor 1
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7
VEGFA vascular endothelial growth factor A