Lupus Erythematosus, Systemic Gene Set

Dataset dbGAP Gene-Trait Associations
Category disease or phenotype associations
Type trait
Description A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart. (Human Disease Ontology, DOID_9074)
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Genes

86 genes associated with the trait Lupus Erythematosus, Systemic in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

Symbol Name Standardized Value
MSH5 mutS homolog 5 1.93306
STAT4 signal transducer and activator of transcription 4 1.82746
TNXB tenascin XB 1.66279
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.63528
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.50783
DXO decapping exoribonuclease 1.33675
STK19 serine/threonine kinase 19 1.33675
ZBTB12 zinc finger and BTB domain containing 12 1.33177
C2 complement component 2 1.33177
TNPO3 transportin 3 1.31782
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.31165
CFB complement factor B 1.30723
C6ORF10 chromosome 6 open reading frame 10 1.27512
BTNL2 butyrophilin-like 2 1.26361
BAG6 BCL2-associated athanogene 6 1.2566
PRRC2A proline-rich coiled-coil 2A 1.24672
CSNK2B casein kinase 2, beta polypeptide 1.23283
GPANK1 G patch domain and ankyrin repeats 1 1.23283
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 1.23281
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 1.22015
NOTCH4 notch 4 1.14898
DPCR1 diffuse panbronchiolitis critical region 1 1.10727
VARS2 valyl-tRNA synthetase 2, mitochondrial 1.09267
TCF19 transcription factor 19 1.08054
WDFY4 WDFY family member 4 1.02473
LRRC18 leucine rich repeat containing 18 1.02473
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.995026
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4 0.995026
DHFRP2 dihydrofolate reductase pseudogene 2 0.991905
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 0.982475
ZSCAN31 zinc finger and SCAN domain containing 31 0.964565
BTN2A1 butyrophilin, subfamily 2, member A1 0.939444
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.934589
HLA-DRB9 major histocompatibility complex, class II, DR beta 9 (pseudogene) 0.93084
HLA-DRA major histocompatibility complex, class II, DR alpha 0.92171
PHRF1 PHD and ring finger domains 1 0.907793
BTN3A2 butyrophilin, subfamily 3, member A2 0.899158
BANK1 B-cell scaffold protein with ankyrin repeats 1 0.897125
UBQLN1P1 ubiquilin 1 pseudogene 1 0.881313
C6ORF15 chromosome 6 open reading frame 15 0.860794
PSORS1C1 psoriasis susceptibility 1 candidate 1 0.860794
ZSCAN12P1 zinc finger and SCAN domain containing 12 pseudogene 1 0.855691
HCG18 HLA complex group 18 (non-protein coding) 0.853812
TNIP1 TNFAIP3 interacting protein 1 0.836775
HIST1H1B histone cluster 1, H1b 0.809374
EHMT2 euchromatic histone-lysine N-methyltransferase 2 0.787424
PGBD1 piggyBac transposable element derived 1 0.782943
PXK PX domain containing serine/threonine kinase 0.781064
AFF1 AF4/FMR2 family, member 1 0.774665
OR12D3 olfactory receptor, family 12, subfamily D, member 3 0.774296
ELF1 E74-like factor 1 (ets domain transcription factor) 0.763999
GPSM3 G-protein signaling modulator 3 0.761603
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 0.757522
ZSCAN26 zinc finger and SCAN domain containing 26 0.746688
HNRNPA1P1 heterogeneous nuclear ribonucleoprotein A1 pseudogene 1 0.742986
HIP1 huntingtin interacting protein 1 0.731179
BLK BLK proto-oncogene, Src family tyrosine kinase 0.731179
CLDN10 claudin 10 0.712186
ZNF112 zinc finger protein 112 0.546884
MUC21 mucin 21, cell surface associated 0.544038
LAMC2 laminin, gamma 2 0.539181
DLG2 discs, large homolog 2 (Drosophila) 0.471111
UBE2L3 ubiquitin-conjugating enzyme E2L 3 0.443956
LEF1 lymphoid enhancer-binding factor 1 0.443956
AUH AU RNA binding protein/enoyl-CoA hydratase 0.428779
NTNG2 netrin G2 0.406869
LY6G6C lymphocyte antigen 6 complex, locus G6C 0.343893
IRF5 interferon regulatory factor 5 0.337303
ZNRD1 zinc ribbon domain containing 1 0.335686
NEGR1 neuronal growth regulator 1 0.323533
OR4A15 olfactory receptor, family 4, subfamily A, member 15 0.323533
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.310838
TMC2 transmembrane channel-like 2 0.310838
HSPA1B heat shock 70kDa protein 1B 0.309212
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 0.303994
HCG9 HLA complex group 9 (non-protein coding) 0.278853
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 0.276601
SRCIN1 SRC kinase signaling inhibitor 1 0.275137
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.267438
PLXNA4 plexin A4 0.24847
RNF39 ring finger protein 39 0.242627
PUM1 pumilio RNA-binding family member 1 0.236272
PVT1 Pvt1 oncogene (non-protein coding) 0.201297
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.190042
TSPAN11 tetraspanin 11 0.182969
VWA7 von Willebrand factor A domain containing 7 0.176009