Lithocholic Acid Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action. (Chemical Entities of Biological Interest Ontology, CHEBI_16325)
External Link http://ctdbase.org/detail.go?type=chem&acc=D008095
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Genes

118 genes/proteins interacting with the chemical Lithocholic Acid from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALB albumin
ALPL alkaline phosphatase, liver/bone/kidney
AR androgen receptor
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BID BH3 interacting domain death agonist
BRCA2 breast cancer 2, early onset
CAMP cathelicidin antimicrobial peptide
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CFL1 cofilin 1 (non-muscle)
CREB1 cAMP responsive element binding protein 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
DIO2 deiodinase, iodothyronine, type II
DIO3 deiodinase, iodothyronine, type III
EFNA1 ephrin-A1
EFNB2 ephrin-B2
EGF epidermal growth factor
EPHA2 EPH receptor A2
EPHB4 EPH receptor B4
FAS Fas cell surface death receptor
GCG glucagon
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GNAT3 guanine nucleotide binding protein, alpha transducing 3
GPBAR1 G protein-coupled bile acid receptor 1
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GSK3B glycogen synthase kinase 3 beta
GSS glutathione synthetase
GSTA1 glutathione S-transferase alpha 1
GSTA3 glutathione S-transferase alpha 3
GSTA4 glutathione S-transferase alpha 4
GSTM1 glutathione S-transferase mu 1
GSTM2 glutathione S-transferase mu 2 (muscle)
HMOX1 heme oxygenase 1
HR hair growth associated
HSPB1 heat shock 27kDa protein 1
ICAM1 intercellular adhesion molecule 1
IL1B interleukin 1, beta
INS insulin
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
LRP2 low density lipoprotein receptor-related protein 2
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MCL1 myeloid cell leukemia 1
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MRAS muscle RAS oncogene homolog
NCOA1 nuclear receptor coactivator 1
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NFE2L2 nuclear factor, erythroid 2-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR1I3 nuclear receptor subfamily 1, group I, member 3
PARP1 poly (ADP-ribose) polymerase 1
PGK1 phosphoglycerate kinase 1
POLB polymerase (DNA directed), beta
PPARA peroxisome proliferator-activated receptor alpha
PRKCB protein kinase C, beta
PTK2 protein tyrosine kinase 2
PXN paxillin
RAB12 RAB12, member RAS oncogene family
RAB3A RAB3A, member RAS oncogene family
RAB3D RAB3D, member RAS oncogene family
RANGAP1 Ran GTPase activating protein 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RNH1 ribonuclease/angiogenin inhibitor 1
RXRA retinoid X receptor, alpha
RXRB retinoid X receptor, beta
SCARB1 scavenger receptor class B, member 1
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMAD3 SMAD family member 3
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STIM1 stromal interaction molecule 1
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
TGFB1 transforming growth factor, beta 1
TNF tumor necrosis factor
TRAP1 TNF receptor-associated protein 1
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
VCAM1 vascular cell adhesion molecule 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WDR1 WD repeat domain 1