Leukemia, Myelogenous, Chronic, BCR-ABL Positive Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

143 genes associated with the Leukemia, Myelogenous, Chronic, BCR-ABL Positive phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C3 aldo-keto reductase family 1, member C3
AKT1 v-akt murine thymoma viral oncogene homolog 1
APAF1 apoptotic peptidase activating factor 1
ARHGAP26 Rho GTPase activating protein 26
ASXL1 additional sex combs like transcriptional regulator 1
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL2L2 BCL2-like 2
BCL6 B-cell CLL/lymphoma 6
BCR breakpoint cluster region
BIRC5 baculoviral IAP repeat containing 5
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD38 CD38 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EPO erythropoietin
ERCC2 excision repair cross-complementation group 2
ESR1 estrogen receptor 1
ETV6 ets variant 6
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FLT3 fms-related tyrosine kinase 3
GATA2 GATA binding protein 2
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB3 major histocompatibility complex, class II, DR beta 3
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HLA-DRB5 major histocompatibility complex, class II, DR beta 5
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFNA1 interferon, alpha 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IL10 interleukin 10
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
IL6 interleukin 6
IRF8 interferon regulatory factor 8
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
KDR kinase insert domain receptor
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KIR2DL5B killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5B
KIR2DP1 killer cell immunoglobulin-like receptor, two domains, pseudogene 1
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KIR2DS2 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
KIR2DS3 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
KIR2DS5 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
KIR3DP1 killer cell immunoglobulin-like receptor, three domains, pseudogene 1
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRAS Kirsten rat sarcoma viral oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEFV Mediterranean fever
MPL MPL proto-oncogene, thrombopoietin receptor
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
ORM1 orosomucoid 1
ORM2 orosomucoid 2
PDCD1 programmed cell death 1
PML promyelocytic leukemia
PTK2 protein tyrosine kinase 2
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RUNX1 runt-related transcription factor 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
TET2 tet methylcytosine dioxygenase 2
TGFB1 transforming growth factor, beta 1
TLX1 T-cell leukemia homeobox 1
TNF tumor necrosis factor
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TP53 tumor protein p53
TYK2 tyrosine kinase 2
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
ULK3 unc-51 like kinase 3
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
WT1 Wilms tumor 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
ZBTB2 zinc finger and BTB domain containing 2