Leukemia, Myelogenous, Chronic, BCR-ABL Positive Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D015464
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Genes

315 genes/proteins associated with the disease Leukemia, Myelogenous, Chronic, BCR-ABL Positive from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
BIRC5 baculoviral IAP repeat containing 5 2.88009
GSTP1 glutathione S-transferase pi 1 2.88009
WT1 Wilms tumor 1 2.88009
ARNTL aryl hydrocarbon receptor nuclear translocator-like 2.88009
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 2.88009
PRTN3 proteinase 3 2.88009
BCR breakpoint cluster region 2.88009
IFNA2 interferon, alpha 2 2.88009
CRY1 cryptochrome circadian clock 1 2.88009
ALOX5 arachidonate 5-lipoxygenase 2.88009
TERT telomerase reverse transcriptase 2.88009
PER3 period circadian clock 3 2.88009
PER2 period circadian clock 2 2.88009
MAPK14 mitogen-activated protein kinase 14 2.88009
HMMR hyaluronan-mediated motility receptor (RHAMM) 2.88009
CA9 carbonic anhydrase IX 2.88009
PRAME preferentially expressed antigen in melanoma 2.88009
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.88009
CRY2 cryptochrome circadian clock 2 2.88009
PER1 period circadian clock 1 2.88009
BCL2L1 BCL2-like 1 2.03599
PARP1 poly (ADP-ribose) polymerase 1 1.94046
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.93216
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.90392
TNF tumor necrosis factor 1.89359
BAX BCL2-associated X protein 1.88277
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.88226
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.84976
TP53 tumor protein p53 1.83485
IL6 interleukin 6 1.77743
BCL2 B-cell CLL/lymphoma 2 1.76946
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 1.73878
CDK2 cyclin-dependent kinase 2 1.73048
CCND3 cyclin D3 1.71687
BAK1 BCL2-antagonist/killer 1 1.70636
CDK1 cyclin-dependent kinase 1 1.70512
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.69909
CXCR4 chemokine (C-X-C motif) receptor 4 1.6947
MCL1 myeloid cell leukemia 1 1.69211
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.68996
DDIT3 DNA-damage-inducible transcript 3 1.67955
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.67718
CDK4 cyclin-dependent kinase 4 1.67376
MAPK3 mitogen-activated protein kinase 3 1.65511
CCNB1 cyclin B1 1.65271
MAPK8 mitogen-activated protein kinase 8 1.64708
MAPK1 mitogen-activated protein kinase 1 1.64528
RB1 retinoblastoma 1 1.64438
RAD51 RAD51 recombinase 1.64123
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.62557
CFLAR CASP8 and FADD-like apoptosis regulator 1.6206
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.6146
BAD BCL2-associated agonist of cell death 1.61014
CCL2 chemokine (C-C motif) ligand 2 1.60664
STAT1 signal transducer and activator of transcription 1, 91kDa 1.60477
VEGFA vascular endothelial growth factor A 1.59896
JUN jun proto-oncogene 1.59849
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.59427
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.59172
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.59054
MMP9 matrix metallopeptidase 9 1.56607
MAPK9 mitogen-activated protein kinase 9 1.55723
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.54669
CYCS cytochrome c, somatic 1.5433
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.54257
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.53772
BIRC3 baculoviral IAP repeat containing 3 1.53579
IL1B interleukin 1, beta 1.52938
FAS Fas cell surface death receptor 1.52667
MAP2K1 mitogen-activated protein kinase kinase 1 1.52011
IL2 interleukin 2 1.51961
CXCL8 chemokine (C-X-C motif) ligand 8 1.51911
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.5181
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.51405
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.5012
DIABLO diablo, IAP-binding mitochondrial protein 1.48351
EGFR epidermal growth factor receptor 1.48325
IFNG interferon, gamma 1.47115
CD69 CD69 molecule 1.46754
CAT catalase 1.45697
TGFB1 transforming growth factor, beta 1 1.45697
EGF epidermal growth factor 1.4522
CCL3 chemokine (C-C motif) ligand 3 1.45089
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.45063
LYN LYN proto-oncogene, Src family tyrosine kinase 1.45036
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 1.44899
CSF1R colony stimulating factor 1 receptor 1.44708
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.44653
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.42859
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 1.42183
CCND1 cyclin D1 1.41802
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.41368
ICAM1 intercellular adhesion molecule 1 1.41202
MPO myeloperoxidase 1.40897
THBS1 thrombospondin 1 1.40595
IL18 interleukin 18 1.39646
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.39646
GDF15 growth differentiation factor 15 1.39646
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.39451
DKK1 dickkopf WNT signaling pathway inhibitor 1 1.3878
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.38696
VIM vimentin 1.38696
TXNIP thioredoxin interacting protein 1.38696
FASLG Fas ligand (TNF superfamily, member 6) 1.38441
ALB albumin 1.37902
HMOX1 heme oxygenase 1 1.37475
CD38 CD38 molecule 1.37446
GADD45A growth arrest and DNA-damage-inducible, alpha 1.37303
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.37246
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.37132
CXCL9 chemokine (C-X-C motif) ligand 9 1.36933
GSR glutathione reductase 1.3682
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.36361
F3 coagulation factor III (thromboplastin, tissue factor) 1.36218
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 1.36161
CCND2 cyclin D2 1.36047
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.35877
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.35877
HSPB1 heat shock 27kDa protein 1 1.35734
COL1A1 collagen, type I, alpha 1 1.35473
VCAM1 vascular cell adhesion molecule 1 1.35299
CXCL10 chemokine (C-X-C motif) ligand 10 1.35242
CCNE1 cyclin E1 1.34782
BTG1 B-cell translocation gene 1, anti-proliferative 1.34723
ACTA2 actin, alpha 2, smooth muscle, aorta 1.34635
BID BH3 interacting domain death agonist 1.34401
CCNA2 cyclin A2 1.3382
GFI1 growth factor independent 1 transcription repressor 1.33553
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 1.33257
COL1A2 collagen, type I, alpha 2 1.33257
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 1.32637
EGR1 early growth response 1 1.32458
ATF3 activating transcription factor 3 1.32192
IRF1 interferon regulatory factor 1 1.30696
ATF5 activating transcription factor 5 1.30574
CCL5 chemokine (C-C motif) ligand 5 1.29843
NGF nerve growth factor (beta polypeptide) 1.28919
GSK3B glycogen synthase kinase 3 beta 1.28549
HSPA8 heat shock 70kDa protein 8 1.28487
CDKN2A cyclin-dependent kinase inhibitor 2A 1.28487
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.28364
SNAI1 snail family zinc finger 1 1.27751
IL4 interleukin 4 1.27689
H2AFX H2A histone family, member X 1.27657
ADM adrenomedullin 1.27471
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.27409
CHUK conserved helix-loop-helix ubiquitous kinase 1.2707
GADD45B growth arrest and DNA-damage-inducible, beta 1.267
BIRC2 baculoviral IAP repeat containing 2 1.26514
FOS FBJ murine osteosarcoma viral oncogene homolog 1.26052
RRAS related RAS viral (r-ras) oncogene homolog 1.25868
FYN FYN proto-oncogene, Src family tyrosine kinase 1.25776
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 1.25776
IGF2 insulin-like growth factor 2 1.25776
COL3A1 collagen, type III, alpha 1 1.25059
BCL2A1 BCL2-related protein A1 1.24687
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.24655
SGK1 serum/glucocorticoid regulated kinase 1 1.2368
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.2368
CDC42 cell division cycle 42 1.23648
BRCA2 breast cancer 2, early onset 1.23137
DUSP2 dual specificity phosphatase 2 1.22758
SP1 Sp1 transcription factor 1.22501
KAT2B K(lysine) acetyltransferase 2B 1.22339
PCNA proliferating cell nuclear antigen 1.22177
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.22177
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.21823
SOD2 superoxide dismutase 2, mitochondrial 1.21791
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 1.21695
HSF1 heat shock transcription factor 1 1.21663
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.21631
FANCD2 Fanconi anemia, complementation group D2 1.21141
HDAC1 histone deacetylase 1 1.20913
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.20719
TPD52L1 tumor protein D52-like 1 1.20361
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.19999
PRKCD protein kinase C, delta 1.19933
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 1.1977
CTSH cathepsin H 1.19574
PLAU plasminogen activator, urokinase 1.19477
NQO2 NAD(P)H dehydrogenase, quinone 2 1.19246
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.1908
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 1.18587
SNAI2 snail family zinc finger 2 1.18159
KDR kinase insert domain receptor 1.17993
CCL4 chemokine (C-C motif) ligand 4 1.17827
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 1.17794
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.17695
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 1.17134
LCK LCK proto-oncogene, Src family tyrosine kinase 1.17134
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 1.17101
MMP2 matrix metallopeptidase 2 1.166
TJP1 tight junction protein 1 1.16533
IGFBP5 insulin-like growth factor binding protein 5 1.16533
PPARG peroxisome proliferator-activated receptor gamma 1.16368
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.16335
S100A9 S100 calcium binding protein A9 1.16335
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.16203
HIST1H1C histone cluster 1, H1c 1.16137
MKI67 marker of proliferation Ki-67 1.16001
F2RL1 coagulation factor II (thrombin) receptor-like 1 1.15797
TIMP1 TIMP metallopeptidase inhibitor 1 1.15763
CDK6 cyclin-dependent kinase 6 1.15729
MMP1 matrix metallopeptidase 1 1.15593
TOP2A topoisomerase (DNA) II alpha 170kDa 1.14919
BORA bora, aurora kinase A activator 1.14816
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.14713
TIMP3 TIMP metallopeptidase inhibitor 3 1.14336
PRKCB protein kinase C, beta 1.14336
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.13963
SMAD3 SMAD family member 3 1.13963
EPO erythropoietin 1.13963
DUSP4 dual specificity phosphatase 4 1.13895
ANXA2 annexin A2 1.13758
BBC3 BCL2 binding component 3 1.13758
RARA retinoic acid receptor, alpha 1.13758
INPP1 inositol polyphosphate-1-phosphatase 1.12564
RRM2 ribonucleotide reductase M2 1.12117
KRT8 keratin 8, type II 1.11945
PRKDC protein kinase, DNA-activated, catalytic polypeptide 1.11877
WEE1 WEE1 G2 checkpoint kinase 1.1129
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.11255
GSTM1 glutathione S-transferase mu 1 1.11116
IL1RN interleukin 1 receptor antagonist 1.11081
BCL6 B-cell CLL/lymphoma 6 1.11046
LMNB1 lamin B1 1.11046
BRCA1 breast cancer 1, early onset 1.10907
PECAM1 platelet/endothelial cell adhesion molecule 1 1.10769
IL10 interleukin 10 1.10631
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 1.10562
ACAN aggrecan 1.10562
IFNB1 interferon, beta 1, fibroblast 1.10493
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 1.10493
EIF4E eukaryotic translation initiation factor 4E 1.10246
MT1X metallothionein 1X 1.10211
CAPN2 calpain 2, (m/II) large subunit 1.10211
ALDOC aldolase C, fructose-bisphosphate 1.09963
IGFBP4 insulin-like growth factor binding protein 4 1.09963
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.09716
EP300 E1A binding protein p300 1.09681
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.09646
MERTK MER proto-oncogene, tyrosine kinase 1.09611
XBP1 X-box binding protein 1 1.09401
GATA3 GATA binding protein 3 1.0919
SON SON DNA binding protein 1.09119
SUMO1 small ubiquitin-like modifier 1 1.09119
IL1A interleukin 1, alpha 1.08975
FAM19A5 family with sequence similarity 19 (chemokine (C-C motif)-like), member A5 1.08797
BTG2 BTG family, member 2 1.08726
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.08726
IL6ST interleukin 6 signal transducer 1.08655
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 1.08655
ATF4 activating transcription factor 4 1.08549
NFE2L2 nuclear factor, erythroid 2-like 2 1.08301
PELI1 pellino E3 ubiquitin protein ligase 1 1.08231
ATM ATM serine/threonine kinase 1.08231
CD14 CD14 molecule 1.07911
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 1.07911
HCK HCK proto-oncogene, Src family tyrosine kinase 1.07804
CD44 CD44 molecule (Indian blood group) 1.07768
SCPEP1 serine carboxypeptidase 1 1.07768
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 1.07768
IL12B interleukin 12B 1.07732
NOS2 nitric oxide synthase 2, inducible 1.07447
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 1.0734
IGF1 insulin-like growth factor 1 (somatomedin C) 1.07305
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 1.07199
CTSD cathepsin D 1.07128
SQSTM1 sequestosome 1 1.06987
FSCN1 fascin actin-bundling protein 1 1.06917
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.06917
TGFBR3 transforming growth factor, beta receptor III 1.06917
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.06661
CXCL12 chemokine (C-X-C motif) ligand 12 1.06515
GHR growth hormone receptor 1.06479
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.0608
ERBB4 erb-b2 receptor tyrosine kinase 4 1.0608
IL13 interleukin 13 1.05793
PDX1 pancreatic and duodenal homeobox 1 1.05757
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 1.05685
GPX1 glutathione peroxidase 1 1.05685
ELAVL1 ELAV like RNA binding protein 1 1.05648
BECN1 beclin 1, autophagy related 1.05573
LIF leukemia inhibitory factor 1.05535
KLF4 Kruppel-like factor 4 (gut) 1.05535
NQO1 NAD(P)H dehydrogenase, quinone 1 1.05423
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 1.05126
CDC6 cell division cycle 6 1.05089
NOS3 nitric oxide synthase 3 (endothelial cell) 1.05015
OCLN occludin 1.04904
MGP matrix Gla protein 1.04868
SRGN serglycin 1.04868
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 1.04647
NR1H3 nuclear receptor subfamily 1, group H, member 3 1.04647
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 1.04465
LGALS1 lectin, galactoside-binding, soluble, 1 1.04427
NAMPT nicotinamide phosphoribosyltransferase 1.04427
TP53INP1 tumor protein p53 inducible nuclear protein 1 1.04088
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1.04014
EEF2 eukaryotic translation elongation factor 2 1.03789
NOTCH1 notch 1 1.03752
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 1.03345
BCL2L2 BCL2-like 2 1.03345
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.03308
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.03159
IFITM1 interferon induced transmembrane protein 1 1.03009
CASP4 caspase 4, apoptosis-related cysteine peptidase 1.02933
SOX17 SRY (sex determining region Y)-box 17 1.02634
ATG5 autophagy related 5 1.02634
DHFR dihydrofolate reductase 1.0189
JUNB jun B proto-oncogene 1.01663
LMCD1 LIM and cysteine-rich domains 1 1.01587
CD36 CD36 molecule (thrombospondin receptor) 1.01512
PTEN phosphatase and tensin homolog 1.01249
HSPB2 heat shock 27kDa protein 2 1.01062