Leukemia, Myelocytic, Acute Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells. (Human Disease Ontology, DOID_9119)
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Genes

48 genes associated with the Leukemia, Myelocytic, Acute phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
BCR breakpoint cluster region
BRCA1 breast cancer 1, early onset
CDA cytidine deaminase
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DHFR dihydrofolate reductase
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC5 excision repair cross-complementation group 5
FAS Fas cell surface death receptor
FLT3 fms-related tyrosine kinase 3
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HLX H2.0-like homeobox
JAK2 Janus kinase 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KMT2A lysine (K)-specific methyltransferase 2A
KRAS Kirsten rat sarcoma viral oncogene homolog
LTA lymphotoxin alpha
MLH1 mutL homolog 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYH11 myosin, heavy chain 11, smooth muscle
NOD2 nucleotide-binding oligomerization domain containing 2
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NR1I2 nuclear receptor subfamily 1, group I, member 2
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PML promyelocytic leukemia
RAD51 RAD51 recombinase
RUNX1 runt-related transcription factor 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TPMT thiopurine S-methyltransferase
VEGFA vascular endothelial growth factor A
XPA xeroderma pigmentosum, complementation group A
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBTB16 zinc finger and BTB domain containing 16