LY-294002-996 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the LY-294002-996 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ACVR1B activin A receptor, type IB
ADAP1 ArfGAP with dual PH domains 1
ADGRG2 adhesion G protein-coupled receptor G2
ALOX15 arachidonate 15-lipoxygenase
ANKRD6 ankyrin repeat domain 6
ATAT1 alpha tubulin acetyltransferase 1
ATP9A ATPase, class II, type 9A
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BRD4 bromodomain containing 4
BTBD7 BTB (POZ) domain containing 7
BTN2A2 butyrophilin, subfamily 2, member A2
C19ORF73 chromosome 19 open reading frame 73
CBX7 chromobox homolog 7
CCDC28B coiled-coil domain containing 28B
CDADC1 cytidine and dCMP deaminase domain containing 1
CDK13 cyclin-dependent kinase 13
CUL7 cullin 7
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DPYSL4 dihydropyrimidinase-like 4
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
EHD2 EH-domain containing 2
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EPHX2 epoxide hydrolase 2, cytoplasmic
ERAP1 endoplasmic reticulum aminopeptidase 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM184A family with sequence similarity 184, member A
FAM188A family with sequence similarity 188, member A
FDPS farnesyl diphosphate synthase
FSTL3 follistatin-like 3 (secreted glycoprotein)
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GRAMD4 GRAM domain containing 4
GSK3A glycogen synthase kinase 3 alpha
GUSBP3 glucuronidase, beta pseudogene 3
HBS1L HBS1-like translational GTPase
HIPK2 homeodomain interacting protein kinase 2
HIPK3 homeodomain interacting protein kinase 3
HRK harakiri, BCL2 interacting protein
IDI2-AS1 IDI2 antisense RNA 1
IFT140 intraflagellar transport 140
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KIAA0754 KIAA0754
KMT2A lysine (K)-specific methyltransferase 2A
KPNA5 karyopherin alpha 5 (importin alpha 6)
KRAS Kirsten rat sarcoma viral oncogene homolog
LIN7A lin-7 homolog A (C. elegans)
LINC00597 long intergenic non-protein coding RNA 597
LOC644450 uncharacterized LOC644450
MAGOH2P mago-nashi homolog 2, pseudogene
MAP9 microtubule-associated protein 9
MAX MYC associated factor X
MCM3AP minichromosome maintenance complex component 3 associated protein
MED27 mediator complex subunit 27
MKL1 megakaryoblastic leukemia (translocation) 1
MTAP methylthioadenosine phosphorylase
NF1 neurofibromin 1
NPFF neuropeptide FF-amide peptide precursor
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRF1 nuclear respiratory factor 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OTUD4 OTU deubiquitinase 4
PASK PAS domain containing serine/threonine kinase
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCNX pecanex homolog (Drosophila)
PDE4DIP phosphodiesterase 4D interacting protein
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4
PRLR prolactin receptor
PVR poliovirus receptor
RALGDS ral guanine nucleotide dissociation stimulator
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
SCAF4 SR-related CTD-associated factor 4
SCAI suppressor of cancer cell invasion
SCAND2P SCAN domain containing 2 pseudogene
SCLY selenocysteine lyase
SEC63 SEC63 homolog (S. cerevisiae)
SFTPB surfactant protein B
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SSBP1 single-stranded DNA binding protein 1, mitochondrial
STK19 serine/threonine kinase 19
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TFPI2 tissue factor pathway inhibitor 2
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TRIM23 tripartite motif containing 23
TRIM33 tripartite motif containing 33
TRIM66 tripartite motif containing 66
TRPV1 transient receptor potential cation channel, subfamily V, member 1
VGF VGF nerve growth factor inducible
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YIPF2 Yip1 domain family, member 2
ZBTB44 zinc finger and BTB domain containing 44
ZER1 zyg-11 related, cell cycle regulator
ZMYM2 zinc finger, MYM-type 2
ZNF227 zinc finger protein 227
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADCY7 adenylate cyclase 7
ADGRE5 adhesion G protein-coupled receptor E5
ADM adrenomedullin
AEN apoptosis enhancing nuclease
AFAP1 actin filament associated protein 1
ASCC2 activating signal cointegrator 1 complex subunit 2
ATAD5 ATPase family, AAA domain containing 5
BAGE B melanoma antigen
BAHCC1 BAH domain and coiled-coil containing 1
BCAS1 breast carcinoma amplified sequence 1
C11ORF30 chromosome 11 open reading frame 30
C16ORF59 chromosome 16 open reading frame 59
CAPG capping protein (actin filament), gelsolin-like
CASP3 caspase 3, apoptosis-related cysteine peptidase
CENPT centromere protein T
CHML choroideremia-like (Rab escort protein 2)
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLCN6 chloride channel, voltage-sensitive 6
DNM1 dynamin 1
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
FAAH fatty acid amide hydrolase
FAM155B family with sequence similarity 155, member B
FAM160B2 family with sequence similarity 160, member B2
FAM86C1 family with sequence similarity 86, member C1
FKBP5 FK506 binding protein 5
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GLRX glutaredoxin (thioltransferase)
GPATCH3 G patch domain containing 3
GRTP1 growth hormone regulated TBC protein 1
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HDAC5 histone deacetylase 5
HIST1H2AG histone cluster 1, H2ag
HS1BP3 HCLS1 binding protein 3
IL17RB interleukin 17 receptor B
INF2 inverted formin, FH2 and WH2 domain containing
IRF7 interferon regulatory factor 7
KDM5C lysine (K)-specific demethylase 5C
KLF7 Kruppel-like factor 7 (ubiquitous)
LAMA5 laminin, alpha 5
LIN7B lin-7 homolog B (C. elegans)
LRRC61 leucine rich repeat containing 61
LYPLA2P1 lysophospholipase II pseudogene 1
MAP1S microtubule-associated protein 1S
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAPK12 mitogen-activated protein kinase 12
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MFSD11 major facilitator superfamily domain containing 11
MPI mannose phosphate isomerase
MRPL44 mitochondrial ribosomal protein L44
NKAIN1 Na+/K+ transporting ATPase interacting 1
NRGN neurogranin (protein kinase C substrate, RC3)
OLFML2A olfactomedin-like 2A
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
OTUD3 OTU deubiquitinase 3
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
P3H1 prolyl 3-hydroxylase 1
PGR progesterone receptor
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PISD phosphatidylserine decarboxylase
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PTDSS2 phosphatidylserine synthase 2
PTPRU protein tyrosine phosphatase, receptor type, U
PYCRL pyrroline-5-carboxylate reductase-like
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RECQL4 RecQ protein-like 4
RFTN1 raftlin, lipid raft linker 1
RNF2 ring finger protein 2
RNF31 ring finger protein 31
RNF39 ring finger protein 39
RPH3AL rabphilin 3A-like (without C2 domains)
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SCD5 stearoyl-CoA desaturase 5
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SPIDR scaffolding protein involved in DNA repair
STARD5 StAR-related lipid transfer (START) domain containing 5
STK25 serine/threonine kinase 25
STRN striatin, calmodulin binding protein
SYNGR3 synaptogyrin 3
TBC1D22A TBC1 domain family, member 22A
THBS3 thrombospondin 3
TNS2 tensin 2
TPTE transmembrane phosphatase with tensin homology
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
UBXN6 UBX domain protein 6
UNC13B unc-13 homolog B (C. elegans)
USP20 ubiquitin specific peptidase 20
ZBTB22 zinc finger and BTB domain containing 22
ZNF408 zinc finger protein 408
ZNF41 zinc finger protein 41
ZNF432 zinc finger protein 432
ZNF510 zinc finger protein 510