LY-294002-6987 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the LY-294002-6987 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCK3 aarF domain containing kinase 3
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANKRD26 ankyrin repeat domain 26
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARMC4 armadillo repeat containing 4
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCL6 B-cell CLL/lymphoma 6
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CALHM2 calcium homeostasis modulator 2
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CD70 CD70 molecule
CRIPT cysteine-rich PDZ-binding protein
CTBP2 C-terminal binding protein 2
DACH1 dachshund family transcription factor 1
DEPTOR DEP domain containing MTOR-interacting protein
DGKQ diacylglycerol kinase, theta 110kDa
DOK5 docking protein 5
ECE1 endothelin converting enzyme 1
ESR1 estrogen receptor 1
EXD3 exonuclease 3'-5' domain containing 3
F11R F11 receptor
FAXDC2 fatty acid hydroxylase domain containing 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
GLS glutaminase
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GM2A GM2 ganglioside activator
GRB7 growth factor receptor-bound protein 7
GSTA4 glutathione S-transferase alpha 4
HBP1 HMG-box transcription factor 1
HIST1H2BC histone cluster 1, H2bc
HIST1H2BO histone cluster 1, H2bo
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HOXC10 homeobox C10
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ING4 inhibitor of growth family, member 4
IRS2 insulin receptor substrate 2
JAG1 jagged 1
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KIAA0430 KIAA0430
KLHL22 kelch-like family member 22
KLHL24 kelch-like family member 24
KRT8P12 keratin 8 pseudogene 12
LIME1 Lck interacting transmembrane adaptor 1
LRRC40 leucine rich repeat containing 40
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MALT1 MALT1 paracaspase
MAPT microtubule-associated protein tau
MED12 mediator complex subunit 12
MED6 mediator complex subunit 6
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
MZF1 myeloid zinc finger 1
N4BP3 NEDD4 binding protein 3
NEBL nebulette
NF2 neurofibromin 2 (merlin)
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLAGL1 pleiomorphic adenoma gene-like 1
PML promyelocytic leukemia
PNRC1 proline-rich nuclear receptor coactivator 1
PRDX2 peroxiredoxin 2
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RAB11B RAB11B, member RAS oncogene family
RBP4 retinol binding protein 4, plasma
RCAN3 RCAN family member 3
REPS2 RALBP1 associated Eps domain containing 2
RIN2 Ras and Rab interactor 2
RNF19B ring finger protein 19B
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RSL1D1 ribosomal L1 domain containing 1
RTN2 reticulon 2
SAMD4A sterile alpha motif domain containing 4A
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SH3BP2 SH3-domain binding protein 2
SIDT2 SID1 transmembrane family, member 2
SIK1 salt-inducible kinase 1
SIK3 SIK family kinase 3
SIRT3 sirtuin 3
SMAD3 SMAD family member 3
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STON1 stonin 1
TACC1 transforming, acidic coiled-coil containing protein 1
TDRKH tudor and KH domain containing
TK2 thymidine kinase 2, mitochondrial
TMEM63A transmembrane protein 63A
TMPRSS2 transmembrane protease, serine 2
TRAPPC9 trafficking protein particle complex 9
TTLL1 tubulin tyrosine ligase-like family member 1
TXNIP thioredoxin interacting protein
UBTD1 ubiquitin domain containing 1
YPEL1 yippee-like 1 (Drosophila)
ZC3H7B zinc finger CCCH-type containing 7B
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ARHGAP10 Rho GTPase activating protein 10
ARMC7 armadillo repeat containing 7
ATAD2B ATPase family, AAA domain containing 2B
ATAD3A ATPase family, AAA domain containing 3A
ATAD5 ATPase family, AAA domain containing 5
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BAG2 BCL2-associated athanogene 2
BTF3P12 basic transcription factor 3 pseudogene 12
C1ORF106 chromosome 1 open reading frame 106
C2CD2 C2 calcium-dependent domain containing 2
CAPN15 calpain 15
CARD8 caspase recruitment domain family, member 8
CCDC86 coiled-coil domain containing 86
CCDC88C coiled-coil domain containing 88C
CDK3 cyclin-dependent kinase 3
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHEK2 checkpoint kinase 2
CHKB choline kinase beta
CHUK conserved helix-loop-helix ubiquitous kinase
CISH cytokine inducible SH2-containing protein
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CTPS1 CTP synthase 1
DCAF17 DDB1 and CUL4 associated factor 17
DDIT3 DNA-damage-inducible transcript 3
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DENND1B DENN/MADD domain containing 1B
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
EGR3 early growth response 3
EIF5A2 eukaryotic translation initiation factor 5A2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FARSA phenylalanyl-tRNA synthetase, alpha subunit
FJX1 four jointed box 1 (Drosophila)
FKBP10 FK506 binding protein 10, 65 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FSD1 fibronectin type III and SPRY domain containing 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GALK1 galactokinase 1
GHR growth hormone receptor
GLB1L2 galactosidase, beta 1-like 2
GMIP GEM interacting protein
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GRWD1 glutamate-rich WD repeat containing 1
HEATR3 HEAT repeat containing 3
HELLS helicase, lymphoid-specific
HIST1H1D histone cluster 1, H1d
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
IL17RB interleukin 17 receptor B
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
JMJD4 jumonji domain containing 4
KIAA0125 KIAA0125
KIAA0895 KIAA0895
LPGAT1 lysophosphatidylglycerol acyltransferase 1
MAGEF1 melanoma antigen family F1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NUPL1 nucleoporin like 1
ORC1 origin recognition complex, subunit 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PANX1 pannexin 1
PARD6A par-6 family cell polarity regulator alpha
PELP1 proline, glutamate and leucine rich protein 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PREB prolactin regulatory element binding
PTPN9 protein tyrosine phosphatase, non-receptor type 9
RAB35 RAB35, member RAS oncogene family
RAB8B RAB8B, member RAS oncogene family
RAD54L RAD54-like (S. cerevisiae)
RAI14 retinoic acid induced 14
RARS arginyl-tRNA synthetase
RBL1 retinoblastoma-like 1
RFTN1 raftlin, lipid raft linker 1
RGS19 regulator of G-protein signaling 19
RHOBTB1 Rho-related BTB domain containing 1
RPUSD2 RNA pseudouridylate synthase domain containing 2
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A4 S100 calcium binding protein A4
SALL2 spalt-like transcription factor 2
SERTAD3 SERTA domain containing 3
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SMYD5 SMYD family member 5
SPHK1 sphingosine kinase 1
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
SYT17 synaptotagmin XVII
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TIPIN TIMELESS interacting protein
TRAF5 TNF receptor-associated factor 5
TTC27 tetratricopeptide repeat domain 27
UBQLN4 ubiquilin 4
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZC3H12A zinc finger CCCH-type containing 12A