LY-294002-6976 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the LY-294002-6976 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ALMS1 Alstrom syndrome protein 1
ANXA2P3 annexin A2 pseudogene 3
ARHGAP33 Rho GTPase activating protein 33
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASZ1 castor zinc finger 1
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CIC capicua transcriptional repressor
CUL9 cullin 9
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DTNA dystrobrevin, alpha
DZIP3 DAZ interacting zinc finger protein 3
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
ERAP1 endoplasmic reticulum aminopeptidase 1
FAM110B family with sequence similarity 110, member B
FAM193B family with sequence similarity 193, member B
FAM53B family with sequence similarity 53, member B
FGD6 FYVE, RhoGEF and PH domain containing 6
FILIP1L filamin A interacting protein 1-like
FZD7 frizzled class receptor 7
GLDC glycine dehydrogenase (decarboxylating)
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GPRASP1 G protein-coupled receptor associated sorting protein 1
HEXA hexosaminidase A (alpha polypeptide)
HPS4 Hermansky-Pudlak syndrome 4
IRF1 interferon regulatory factor 1
IRF6 interferon regulatory factor 6
JAG1 jagged 1
KCNK12 potassium channel, two pore domain subfamily K, member 12
KIAA0485 uncharacterized LOC57235
LAT2 linker for activation of T cells family, member 2
LMO2 LIM domain only 2 (rhombotin-like 1)
LPIN1 lipin 1
LRRC14 leucine rich repeat containing 14
LRRC37A3 leucine rich repeat containing 37, member A3
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAPT microtubule-associated protein tau
MED15 mediator complex subunit 15
MMP15 matrix metallopeptidase 15 (membrane-inserted)
NCAPH2 non-SMC condensin II complex, subunit H2
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NEBL nebulette
NOP16 NOP16 nucleolar protein
NPIPB3 nuclear pore complex interacting protein family, member B3
NUMA1 nuclear mitotic apparatus protein 1
OPLAH 5-oxoprolinase (ATP-hydrolysing)
OR3A3 olfactory receptor, family 3, subfamily A, member 3
PALM paralemmin
PAQR6 progestin and adipoQ receptor family member VI
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX5 paired box 5
PDE4DIP phosphodiesterase 4D interacting protein
PENK proenkephalin
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PXDC1 PX domain containing 1
RAD54B RAD54 homolog B (S. cerevisiae)
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RNF123 ring finger protein 123
RPL35A ribosomal protein L35a
RPS14 ribosomal protein S14
RRBP1 ribosome binding protein 1
RTEL1 regulator of telomere elongation helicase 1
RUNX1 runt-related transcription factor 1
SAA4 serum amyloid A4, constitutive
SCD5 stearoyl-CoA desaturase 5
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SFXN3 sideroflexin 3
SH3GL3 SH3-domain GRB2-like 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SMG5 SMG5 nonsense mediated mRNA decay factor
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome)
STAG3L1 stromal antigen 3-like 1 (pseudogene)
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
THBS1 thrombospondin 1
TIMELESS timeless circadian clock
TLR5 toll-like receptor 5
TMC5 transmembrane channel-like 5
TRIM25 tripartite motif containing 25
UBTD1 ubiquitin domain containing 1
UTRN utrophin
VDAC3 voltage-dependent anion channel 3
VIPR2 vasoactive intestinal peptide receptor 2
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
ZFP37 ZFP37 zinc finger protein
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AGBL5 ATP/GTP binding protein-like 5
ANKRD28 ankyrin repeat domain 28
BATF basic leucine zipper transcription factor, ATF-like
BBS4 Bardet-Biedl syndrome 4
BPGM 2,3-bisphosphoglycerate mutase
BTF3P12 basic transcription factor 3 pseudogene 12
C16ORF59 chromosome 16 open reading frame 59
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
CCDC85C coiled-coil domain containing 85C
CCDC88C coiled-coil domain containing 88C
CCDC91 coiled-coil domain containing 91
CDC42BPB CDC42 binding protein kinase beta (DMPK-like)
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit
CNPY3 canopy FGF signaling regulator 3
CSTA cystatin A (stefin A)
CUEDC1 CUE domain containing 1
DNAAF2 dynein, axonemal, assembly factor 2
DNAL4 dynein, axonemal, light chain 4
DVL1 dishevelled segment polarity protein 1
EFCAB2 EF-hand calcium binding domain 2
EFHD2 EF-hand domain family, member D2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FAM86C1 family with sequence similarity 86, member C1
FBXO31 F-box protein 31
FOSL1 FOS-like antigen 1
FXN frataxin
GALK1 galactokinase 1
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GLCE glucuronic acid epimerase
GMPPA GDP-mannose pyrophosphorylase A
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
HHLA3 HERV-H LTR-associating 3
HIST1H1C histone cluster 1, H1c
HLA-J major histocompatibility complex, class I, J (pseudogene)
HMGB3P1 high mobility group box 3 pseudogene 1
HOXA5 homeobox A5
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
ING3 inhibitor of growth family, member 3
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JUNB jun B proto-oncogene
KIZ kizuna centrosomal protein
KLHL21 kelch-like family member 21
LIN7A lin-7 homolog A (C. elegans)
LINC00339 long intergenic non-protein coding RNA 339
LRRC37A2 leucine rich repeat containing 37, member A2
LRRC8E leucine rich repeat containing 8 family, member E
LYPD1 LY6/PLAUR domain containing 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MTCL1 microtubule crosslinking factor 1
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
NINJ1 ninjurin 1
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OR7E37P olfactory receptor, family 7, subfamily E, member 37 pseudogene
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PPT2 palmitoyl-protein thioesterase 2
PRR7 proline rich 7 (synaptic)
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
PYCRL pyrroline-5-carboxylate reductase-like
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RGS19 regulator of G-protein signaling 19
RIBC2 RIB43A domain with coiled-coils 2
S100A4 S100 calcium binding protein A4
SF3A2 splicing factor 3a, subunit 2, 66kDa
SFT2D2 SFT2 domain containing 2
SH2B3 SH2B adaptor protein 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein
SMAGP small cell adhesion glycoprotein
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SNUPN snurportin 1
SNX24 sorting nexin 24
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SYT17 synaptotagmin XVII
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TESK2 testis-specific kinase 2
TFF3 trefoil factor 3 (intestinal)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TSPAN1 tetraspanin 1
TTC4 tetratricopeptide repeat domain 4
ULBP2 UL16 binding protein 2
VASH2 vasohibin 2
VGF VGF nerve growth factor inducible
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZDHHC18 zinc finger, DHHC-type containing 18
ZNF211 zinc finger protein 211
ZNF280D zinc finger protein 280D
ZNF350 zinc finger protein 350