LY-294002-6935 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the LY-294002-6935 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2
AK1 adenylate kinase 1
ALDOAP2 aldolase A, fructose-bisphosphate pseudogene 2
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ASPHD1 aspartate beta-hydroxylase domain containing 1
BLZF1 basic leucine zipper nuclear factor 1
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C22ORF46 chromosome 22 open reading frame 46
CCNG2 cyclin G2
CD28 CD28 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CGA glycoprotein hormones, alpha polypeptide
CHMP6 charged multivesicular body protein 6
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
CXCR2 chemokine (C-X-C motif) receptor 2
CYLD cylindromatosis (turban tumor syndrome)
CYSLTR1 cysteinyl leukotriene receptor 1
DCTN1 dynactin 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DENND3 DENN/MADD domain containing 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DRD2 dopamine receptor D2
DUSP10 dual specificity phosphatase 10
EMID1 EMI domain containing 1
EXTL3 exostosin-like glycosyltransferase 3
FAM149A family with sequence similarity 149, member A
FAM169A family with sequence similarity 169, member A
FAM214B family with sequence similarity 214, member B
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FRZB frizzled-related protein
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GFER growth factor, augmenter of liver regeneration
GLB1L2 galactosidase, beta 1-like 2
HMGN5 high mobility group nucleosome binding domain 5
HOXA4 homeobox A4
HOXC10 homeobox C10
HOXC8 homeobox C8
HYI hydroxypyruvate isomerase (putative)
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IRF9 interferon regulatory factor 9
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LIME1 Lck interacting transmembrane adaptor 1
LIMS2 LIM and senescent cell antigen-like domains 2
LOC399491
LOXL3 lysyl oxidase-like 3
LPAR4 lysophosphatidic acid receptor 4
LRMP lymphoid-restricted membrane protein
MARK4 MAP/microtubule affinity-regulating kinase 4
MIIP migration and invasion inhibitory protein
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPS12 mitochondrial ribosomal protein S12
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
NEBL nebulette
NT5E 5'-nucleotidase, ecto (CD73)
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PDE4DIP phosphodiesterase 4D interacting protein
PLD2 phospholipase D2
PRDX2 peroxiredoxin 2
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RAD51B RAD51 paralog B
RER1 retention in endoplasmic reticulum sorting receptor 1
RGS3 regulator of G-protein signaling 3
RPGR retinitis pigmentosa GTPase regulator
S100A4 S100 calcium binding protein A4
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SGSM2 small G protein signaling modulator 2
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMC5 structural maintenance of chromosomes 5
SOX10 SRY (sex determining region Y)-box 10
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SSX3 synovial sarcoma, X breakpoint 3
TIMELESS timeless circadian clock
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIM66 tripartite motif containing 66
U2SURP U2 snRNP-associated SURP domain containing
UNC5B unc-5 homolog B (C. elegans)
UNC5C unc-5 homolog C (C. elegans)
WDR62 WD repeat domain 62
WNT1 wingless-type MMTV integration site family, member 1
YLPM1 YLP motif containing 1
ZNF510 zinc finger protein 510
ZNF770 zinc finger protein 770
ZXDB zinc finger, X-linked, duplicated B

decreased expression

Symbol Name
AEN apoptosis enhancing nuclease
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ASB7 ankyrin repeat and SOCS box containing 7
BATF basic leucine zipper transcription factor, ATF-like
BBS10 Bardet-Biedl syndrome 10
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BHLHB9 basic helix-loop-helix domain containing, class B, 9
BMP4 bone morphogenetic protein 4
BORA bora, aurora kinase A activator
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C10ORF88 chromosome 10 open reading frame 88
C11ORF57 chromosome 11 open reading frame 57
C12ORF43 chromosome 12 open reading frame 43
CAPN5 calpain 5
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCDC88C coiled-coil domain containing 88C
CCDC91 coiled-coil domain containing 91
CCS copper chaperone for superoxide dismutase
CDKL3 cyclin-dependent kinase-like 3
CHMP7 charged multivesicular body protein 7
CHPF chondroitin polymerizing factor
COCH cochlin
DDIT3 DNA-damage-inducible transcript 3
DNAL4 dynein, axonemal, light chain 4
DTX4 deltex 4, E3 ubiquitin ligase
EDC3 enhancer of mRNA decapping 3
EDC4 enhancer of mRNA decapping 4
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EXOC5 exocyst complex component 5
FAM155B family with sequence similarity 155, member B
FLT4 fms-related tyrosine kinase 4
FPGS folylpolyglutamate synthase
GLCE glucuronic acid epimerase
GRWD1 glutamate-rich WD repeat containing 1
HIST1H2AJ histone cluster 1, H2aj
HIST1H3B histone cluster 1, H3b
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HP1BP3 heterochromatin protein 1, binding protein 3
ICK intestinal cell (MAK-like) kinase
IER3IP1 immediate early response 3 interacting protein 1
IGFBP6 insulin-like growth factor binding protein 6
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL4R interleukin 4 receptor
IRX4 iroquois homeobox 4
KPTN kaptin (actin binding protein)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LINS lines homolog (Drosophila)
LOC642236 FSHD region gene 1 pseudogene
LRRC20 leucine rich repeat containing 20
MAP9 microtubule-associated protein 9
MAPKBP1 mitogen-activated protein kinase binding protein 1
MAST3 microtubule associated serine/threonine kinase 3
MBOAT2 membrane bound O-acyltransferase domain containing 2
METTL4 methyltransferase like 4
MMP9 matrix metallopeptidase 9
MPI mannose phosphate isomerase
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NARFL nuclear prelamin A recognition factor-like
NOTCH1 notch 1
NPY5R neuropeptide Y receptor Y5
NRGN neurogranin (protein kinase C substrate, RC3)
OGFRL1 opioid growth factor receptor-like 1
PCOLCE2 procollagen C-endopeptidase enhancer 2
PCSK7 proprotein convertase subtilisin/kexin type 7
PEX26 peroxisomal biogenesis factor 26
PILRB paired immunoglobin-like type 2 receptor beta
PODXL2 podocalyxin-like 2
PXMP4 peroxisomal membrane protein 4, 24kDa
QTRT1 queuine tRNA-ribosyltransferase 1
RAB17 RAB17, member RAS oncogene family
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RBM41 RNA binding motif protein 41
RGS17 regulator of G-protein signaling 17
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RWDD2A RWD domain containing 2A
SCN1B sodium channel, voltage gated, type I beta subunit
SFXN3 sideroflexin 3
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SNORA21 small nucleolar RNA, H/ACA box 21
SPAG7 sperm associated antigen 7
SPATA7 spermatogenesis associated 7
STAG3L1 stromal antigen 3-like 1 (pseudogene)
TMEM165 transmembrane protein 165
TMEM184B transmembrane protein 184B
TMEM2 transmembrane protein 2
TMEM39B transmembrane protein 39B
TNS2 tensin 2
TPRA1 transmembrane protein, adipocyte asscociated 1
TTC17 tetratricopeptide repeat domain 17
TTC26 tetratricopeptide repeat domain 26
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VASH2 vasohibin 2
VGF VGF nerve growth factor inducible
XKR8 XK, Kell blood group complex subunit-related family, member 8
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZMYM3 zinc finger, MYM-type 3
ZNF324 zinc finger protein 324
ZNF675 zinc finger protein 675
ZNF813 zinc finger protein 813