LY-294002-6186 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the LY-294002-6186 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ACACB acetyl-CoA carboxylase beta
ACTC1 actin, alpha, cardiac muscle 1
ADAM3A ADAM metallopeptidase domain 3A (pseudogene)
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
AQP9 aquaporin 9
ATN1 atrophin 1
AURKA aurora kinase A
BAIAP2 BAI1-associated protein 2
BAIAP3 BAI1-associated protein 3
BRS3 bombesin-like receptor 3
C11ORF16 chromosome 11 open reading frame 16
C11ORF63 chromosome 11 open reading frame 63
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP4 caspase 4, apoptosis-related cysteine peptidase
CHGB chromogranin B
CKM creatine kinase, muscle
DAPK3 death-associated protein kinase 3
DICER1 dicer 1, ribonuclease type III
DLG1 discs, large homolog 1 (Drosophila)
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like
EED embryonic ectoderm development
EPS8L3 EPS8-like 3
FAXDC2 fatty acid hydroxylase domain containing 2
FBXO31 F-box protein 31
FGF16 fibroblast growth factor 16
FGFR1 fibroblast growth factor receptor 1
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GAREM GRB2 associated, regulator of MAPK1
GIMAP4 GTPase, IMAP family member 4
GLRA3 glycine receptor, alpha 3
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTPBP1 GTP binding protein 1
HAMP hepcidin antimicrobial peptide
HIST1H2AK histone cluster 1, H2ak
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H3H histone cluster 1, H3h
HOMER2 homer scaffolding protein 2
IL15RA interleukin 15 receptor, alpha
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
LTBP2 latent transforming growth factor beta binding protein 2
MAP2K6 mitogen-activated protein kinase kinase 6
MAP2K7 mitogen-activated protein kinase kinase 7
MAPK11 mitogen-activated protein kinase 11
MLXIP MLX interacting protein
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC13 mucin 13, cell surface associated
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NF2 neurofibromin 2 (merlin)
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NIPAL2 NIPA-like domain containing 2
NNAT neuronatin
OLFML2B olfactomedin-like 2B
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PARD6A par-6 family cell polarity regulator alpha
PCLO piccolo presynaptic cytomatrix protein
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDE4DIP phosphodiesterase 4D interacting protein
PEX11A peroxisomal biogenesis factor 11 alpha
PKP3 plakophilin 3
PLD2 phospholipase D2
PLD3 phospholipase D family, member 3
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
RAB13 RAB13, member RAS oncogene family
RGS5 regulator of G-protein signaling 5
RPL13P5 ribosomal protein L13 pseudogene 5
RPL7 ribosomal protein L7
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SARM1 sterile alpha and TIR motif containing 1
SCN11A sodium channel, voltage gated, type XI alpha subunit
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SERHL2 serine hydrolase-like 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC22A17 solute carrier family 22, member 17
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SOX10 SRY (sex determining region Y)-box 10
STK17A serine/threonine kinase 17a
TEF thyrotrophic embryonic factor
TEK TEK tyrosine kinase, endothelial
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TRIM10 tripartite motif containing 10
TRIM23 tripartite motif containing 23
TRIM36 tripartite motif containing 36
ZBTB20 zinc finger and BTB domain containing 20
ZER1 zyg-11 related, cell cycle regulator
ZNF132 zinc finger protein 132
ZXDB zinc finger, X-linked, duplicated B

decreased expression

Symbol Name
ADORA3 adenosine A3 receptor
ANKRD55 ankyrin repeat domain 55
ANXA3 annexin A3
ARRB1 arrestin, beta 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
BATF3 basic leucine zipper transcription factor, ATF-like 3
C5 complement component 5
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CBS cystathionine-beta-synthase
CCDC86 coiled-coil domain containing 86
CCDC88C coiled-coil domain containing 88C
CCL2 chemokine (C-C motif) ligand 2
CCNA1 cyclin A1
CD69 CD69 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CTH cystathionine gamma-lyase
CTSG cathepsin G
CUX2 cut-like homeobox 2
DDIT4 DNA-damage-inducible transcript 4
DDN dendrin
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DHRS9 dehydrogenase/reductase (SDR family) member 9
DIXDC1 DIX domain containing 1
ECM1 extracellular matrix protein 1
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ERAP2 endoplasmic reticulum aminopeptidase 2
FAM86B1 family with sequence similarity 86, member B1
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FPGS folylpolyglutamate synthase
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
HP haptoglobin
IL1R2 interleukin 1 receptor, type II
JMJD4 jumonji domain containing 4
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNK5 potassium channel, two pore domain subfamily K, member 5
KIAA1024 KIAA1024
KIF21B kinesin family member 21B
KLF11 Kruppel-like factor 11
KLHL26 kelch-like family member 26
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIN7A lin-7 homolog A (C. elegans)
MDN1 MDN1, midasin homolog (yeast)
MON1B MON1 secretory trafficking family member B
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBEAL2 neurobeachin-like 2
NOL6 nucleolar protein 6 (RNA-associated)
NPIPB3 nuclear pore complex interacting protein family, member B3
NT5DC3 5'-nucleotidase domain containing 3
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
ORM1 orosomucoid 1
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDZD7 PDZ domain containing 7
PFAS phosphoribosylformylglycinamidine synthase
PHC1 polyhomeotic homolog 1 (Drosophila)
PID1 phosphotyrosine interaction domain containing 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
POMZP3 POM121 and ZP3 fusion
PPARG peroxisome proliferator-activated receptor gamma
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSAT1 phosphoserine aminotransferase 1
PUS7 pseudouridylate synthase 7 (putative)
QTRT1 queuine tRNA-ribosyltransferase 1
RFTN1 raftlin, lipid raft linker 1
RGS13 regulator of G-protein signaling 13
RGS16 regulator of G-protein signaling 16
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNF122 ring finger protein 122
S100P S100 calcium binding protein P
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SIGLEC9 sialic acid binding Ig-like lectin 9
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
STC2 stanniocalcin 2
TERT telomerase reverse transcriptase
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TGM5 transglutaminase 5
THBS4 thrombospondin 4
TICAM1 toll-like receptor adaptor molecule 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB3 tribbles pseudokinase 3
UPK3A uroplakin 3A
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
VN1R1 vomeronasal 1 receptor 1
WDR3 WD repeat domain 3
WNT10B wingless-type MMTV integration site family, member 10B
ZHX2 zinc fingers and homeoboxes 2
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF354A zinc finger protein 354A