LY-294002-5937 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the LY-294002-5937 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AASS aminoadipate-semialdehyde synthase
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACPP acid phosphatase, prostate
AKAP10 A kinase (PRKA) anchor protein 10
APOLD1 apolipoprotein L domain containing 1
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARID1A AT rich interactive domain 1A (SWI-like)
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
C8ORF44 chromosome 8 open reading frame 44
CALB2 calbindin 2
CCNT2 cyclin T2
CD40LG CD40 ligand
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL11A2 collagen, type XI, alpha 2
COL6A1 collagen, type VI, alpha 1
COMT catechol-O-methyltransferase
CPA4 carboxypeptidase A4
CSF1R colony stimulating factor 1 receptor
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DMPK dystrophia myotonica-protein kinase
DNASE1 deoxyribonuclease I
DOK3 docking protein 3
DVL3 dishevelled segment polarity protein 3
ENO3 enolase 3 (beta, muscle)
ETV6 ets variant 6
ETV7 ets variant 7
F9 coagulation factor IX
FAM107A family with sequence similarity 107, member A
FAM134B family with sequence similarity 134, member B
FBLN1 fibulin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GOSR2 golgi SNAP receptor complex member 2
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GPR21 G protein-coupled receptor 21
HAS1 hyaluronan synthase 1
HIST1H2AI histone cluster 1, H2ai
ICA1 islet cell autoantigen 1, 69kDa
IRS2 insulin receptor substrate 2
KLHL24 kelch-like family member 24
KRIT1 KRIT1, ankyrin repeat containing
KSR1 kinase suppressor of ras 1
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LMNA lamin A/C
LTC4S leukotriene C4 synthase
MAPK4 mitogen-activated protein kinase 4
MEF2D myocyte enhancer factor 2D
MST1 macrophage stimulating 1
NEFM neurofilament, medium polypeptide
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae)
NRL neural retina leucine zipper
NRTN neurturin
NT5E 5'-nucleotidase, ecto (CD73)
NUP214 nucleoporin 214kDa
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PDCD2 programmed cell death 2
PENK proenkephalin
PLK3 polo-like kinase 3
POPDC2 popeye domain containing 2
PRMT8 protein arginine methyltransferase 8
PROX1 prospero homeobox 1
PVR poliovirus receptor
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
RNF126P1 ring finger protein 126 pseudogene 1
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
RPL10 ribosomal protein L10
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SH3D21 SH3 domain containing 21
SIRT3 sirtuin 3
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SNCAIP synuclein, alpha interacting protein
SPARCL1 SPARC-like 1 (hevin)
SPDEF SAM pointed domain containing ETS transcription factor
SPINK5 serine peptidase inhibitor, Kazal type 5
SRGN serglycin
SS18 synovial sarcoma translocation, chromosome 18
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
TBCD tubulin folding cofactor D
TBX10 T-box 10
TBXA2R thromboxane A2 receptor
TEX15 testis expressed 15
TEX261 testis expressed 261
TNS1 tensin 1
TRIM25 tripartite motif containing 25
TXNIP thioredoxin interacting protein
UBOX5 U-box domain containing 5
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
VWA5A von Willebrand factor A domain containing 5A
YPEL1 yippee-like 1 (Drosophila)
YY2 YY2 transcription factor
ZC3H13 zinc finger CCCH-type containing 13
ZNF10 zinc finger protein 10
ZNF136 zinc finger protein 136
ZNF304 zinc finger protein 304
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
ADORA2B adenosine A2b receptor
ARC activity-regulated cytoskeleton-associated protein
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BAG2 BCL2-associated athanogene 2
BATF3 basic leucine zipper transcription factor, ATF-like 3
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCO1 beta-carotene oxygenase 1
BEGAIN brain-enriched guanylate kinase-associated
BLNK B-cell linker
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C2CD2 C2 calcium-dependent domain containing 2
CA2 carbonic anhydrase II
CALML5 calmodulin-like 5
CD302 CD302 molecule
CHML choroideremia-like (Rab escort protein 2)
CHST10 carbohydrate sulfotransferase 10
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
COL9A3 collagen, type IX, alpha 3
CPOX coproporphyrinogen oxidase
CRMP1 collapsin response mediator protein 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
DNAAF2 dynein, axonemal, assembly factor 2
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DTX2 deltex 2, E3 ubiquitin ligase
E2F8 E2F transcription factor 8
ELSPBP1 epididymal sperm binding protein 1
EXD3 exonuclease 3'-5' domain containing 3
FAM169A family with sequence similarity 169, member A
FBXO22 F-box protein 22
FGD1 FYVE, RhoGEF and PH domain containing 1
FKBP10 FK506 binding protein 10, 65 kDa
FOXN2 forkhead box N2
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GATA4 GATA binding protein 4
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GJA1 gap junction protein, alpha 1, 43kDa
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GRAMD1C GRAM domain containing 1C
GTF2I general transcription factor IIi
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HPN hepsin
ITPKB inositol-trisphosphate 3-kinase B
JAK2 Janus kinase 2
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIAA0125 KIAA0125
KIAA0895 KIAA0895
KLHL21 kelch-like family member 21
LOC390998 ribosomal protein L10 pseudogene
LY6D lymphocyte antigen 6 complex, locus D
MAGOHB mago-nashi homolog B (Drosophila)
MANEA mannosidase, endo-alpha
MEGF8 multiple EGF-like-domains 8
MSX1 msh homeobox 1
MVD mevalonate (diphospho) decarboxylase
NFE2L3 nuclear factor, erythroid 2-like 3
NME5 NME/NM23 family member 5
NPTX1 neuronal pentraxin I
NYNRIN NYN domain and retroviral integrase containing
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PARPBP PARP1 binding protein
PCDHB13 protocadherin beta 13
PER3 period circadian clock 3
PHEX phosphate regulating endopeptidase homolog, X-linked
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLA2G3 phospholipase A2, group III
PLAC8 placenta-specific 8
R3HCC1L R3H domain and coiled-coil containing 1-like
RNF146 ring finger protein 146
RPGRIP1L RPGRIP1-like
S100A2 S100 calcium binding protein A2
SAYSD1 SAYSVFN motif domain containing 1
SDC3 syndecan 3
SGK1 serum/glucocorticoid regulated kinase 1
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMCO4 single-pass membrane protein with coiled-coil domains 4
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNHG3 small nucleolar RNA host gene 3
SOAT1 sterol O-acyltransferase 1
SPAG1 sperm associated antigen 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TUBA3D tubulin, alpha 3d
VASH2 vasohibin 2
VLDLR very low density lipoprotein receptor
ZFP69B ZFP69 zinc finger protein B
ZNF329 zinc finger protein 329
ZNF428 zinc finger protein 428
ZNF532 zinc finger protein 532
ZNF750 zinc finger protein 750