LY-294002-461 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the LY-294002-461 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSM3 acyl-CoA synthetase medium-chain family member 3
AFF1 AF4/FMR2 family, member 1
AGRN agrin
AKAP8L A kinase (PRKA) anchor protein 8-like
AKAP9 A kinase (PRKA) anchor protein 9
AMT aminomethyltransferase
ANG angiogenin, ribonuclease, RNase A family, 5
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASB13 ankyrin repeat and SOCS box containing 13
ATXN1 ataxin 1
BCL6 B-cell CLL/lymphoma 6
BGN biglycan
BICD1 bicaudal D homolog 1 (Drosophila)
BMP5 bone morphogenetic protein 5
BRAF B-Raf proto-oncogene, serine/threonine kinase
C6ORF62 chromosome 6 open reading frame 62
CADM3 cell adhesion molecule 3
CAMKV CaM kinase-like vesicle-associated
CAV3 caveolin 3
CD2AP CD2-associated protein
CD4 CD4 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD79A CD79a molecule, immunoglobulin-associated alpha
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CELF2 CUGBP, Elav-like family member 2
CFAP74 cilia and flagella associated protein 74
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC1A C-type lectin domain family 1, member A
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CPB1 carboxypeptidase B1 (tissue)
CTBS chitobiase, di-N-acetyl-
CYB5R2 cytochrome b5 reductase 2
DENND1C DENN/MADD domain containing 1C
EXTL2 exostosin-like glycosyltransferase 2
FAM63A family with sequence similarity 63, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FOXA2 forkhead box A2
GAB2 GRB2-associated binding protein 2
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GK glycerol kinase
GPR35 G protein-coupled receptor 35
HERC2P3 hect domain and RLD 2 pseudogene 3
HHIPL2 HHIP-like 2
HIST1H2BG histone cluster 1, H2bg
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXA9 homeobox A9
IFNA4 interferon, alpha 4
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRF8 interferon regulatory factor 8
KIAA1033 KIAA1033
KLHL24 kelch-like family member 24
KLHL35 kelch-like family member 35
KRT17 keratin 17, type I
LUZP4 leucine zipper protein 4
MAGEA5 melanoma antigen family A5
MBNL2 muscleblind-like splicing regulator 2
MTF1 metal-regulatory transcription factor 1
MXD3 MAX dimerization protein 3
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PAQR6 progestin and adipoQ receptor family member VI
PEX11A peroxisomal biogenesis factor 11 alpha
PIGR polymeric immunoglobulin receptor
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLSCR4 phospholipid scramblase 4
PRDM11 PR domain containing 11
PSG3 pregnancy specific beta-1-glycoprotein 3
PSIP1 PC4 and SFRS1 interacting protein 1
PTCRA pre T-cell antigen receptor alpha
RAB15 RAB15, member RAS oncogene family
RARB retinoic acid receptor, beta
RBKS ribokinase
RBM5 RNA binding motif protein 5
RNF39 ring finger protein 39
RSL1D1 ribosomal L1 domain containing 1
SFTPB surfactant protein B
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3
SLC35F6 solute carrier family 35, member F6
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRSF5 serine/arginine-rich splicing factor 5
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SYNGR1 synaptogyrin 1
TCL1A T-cell leukemia/lymphoma 1A
TESK2 testis-specific kinase 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM156 transmembrane protein 156
TMEM176A transmembrane protein 176A
UBE3A ubiquitin protein ligase E3A
ZC3H13 zinc finger CCCH-type containing 13
ZKSCAN8 zinc finger with KRAB and SCAN domains 8
ZNF480 zinc finger protein 480

decreased expression

Symbol Name
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
BCAS4 breast carcinoma amplified sequence 4
BLMH bleomycin hydrolase
BTBD2 BTB (POZ) domain containing 2
C3ORF18 chromosome 3 open reading frame 18
C7ORF43 chromosome 7 open reading frame 43
CCNO cyclin O
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CHKA choline kinase alpha
CNGB3 cyclic nucleotide gated channel beta 3
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COA7 cytochrome c oxidase assembly factor 7 (putative)
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DNASE1L2 deoxyribonuclease I-like 2
ELAVL2 ELAV like neuron-specific RNA binding protein 2
EMC9 ER membrane protein complex subunit 9
FAF1 Fas (TNFRSF6) associated factor 1
FASTKD5 FAST kinase domains 5
FCGRT Fc fragment of IgG, receptor, transporter, alpha
G0S2 G0/G1 switch 2
GBAP1 glucosidase, beta, acid pseudogene 1
GEMIN6 gem (nuclear organelle) associated protein 6
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GRAMD3 GRAM domain containing 3
GRWD1 glutamate-rich WD repeat containing 1
GSTT1 glutathione S-transferase theta 1
HAS2 hyaluronan synthase 2
HIRA histone cell cycle regulator
HK2 hexokinase 2
HP1BP3 heterochromatin protein 1, binding protein 3
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
KIFC1 kinesin family member C1
LDHC lactate dehydrogenase C
LHX6 LIM homeobox 6
LMNB1 lamin B1
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
MARC1 mitochondrial amidoxime reducing component 1
MFSD12 major facilitator superfamily domain containing 12
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
MRPL17 mitochondrial ribosomal protein L17
MRPS2 mitochondrial ribosomal protein S2
MRPS34 mitochondrial ribosomal protein S34
MYBBP1A MYB binding protein (P160) 1a
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NCF2 neutrophil cytosolic factor 2
NINJ1 ninjurin 1
NIP7 NIP7, nucleolar pre-rRNA processing protein
NOL6 nucleolar protein 6 (RNA-associated)
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PAK1IP1 PAK1 interacting protein 1
PES1 pescadillo ribosomal biogenesis factor 1
PHKG2 phosphorylase kinase, gamma 2 (testis)
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLEKHO2 pleckstrin homology domain containing, family O member 2
POLM polymerase (DNA directed), mu
PUS1 pseudouridylate synthase 1
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)
RPE ribulose-5-phosphate-3-epimerase
RPUSD2 RNA pseudouridylate synthase domain containing 2
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEPHS2 selenophosphate synthetase 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH2B2 SH2B adaptor protein 2
SH3GL1 SH3-domain GRB2-like 1
SIAH2 siah E3 ubiquitin protein ligase 2
SLC10A3 solute carrier family 10, member 3
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMYD5 SMYD family member 5
SNRPF small nuclear ribonucleoprotein polypeptide F
SPATS2 spermatogenesis associated, serine-rich 2
TBL3 transducin (beta)-like 3
THOC6 THO complex 6
TMEM127 transmembrane protein 127
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNS2 tensin 2
TRAPPC12 trafficking protein particle complex 12
TSKU tsukushi, small leucine rich proteoglycan
TSSC4 tumor suppressing subtransferable candidate 4
UBL4A ubiquitin-like 4A
UPP1 uridine phosphorylase 1
VIPR1 vasoactive intestinal peptide receptor 1
WDR46 WD repeat domain 46
ZNF324 zinc finger protein 324
ZNF696 zinc finger protein 696