LY-294002-4463 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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194 genes differentially expressed following the LY-294002-4463 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABI2 abl-interactor 2
AGXT alanine-glyoxylate aminotransferase
AHSP alpha hemoglobin stabilizing protein
AKAP13 A kinase (PRKA) anchor protein 13
AKAP9 A kinase (PRKA) anchor protein 9
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
APAF1 apoptotic peptidase activating factor 1
APOE apolipoprotein E
ARL14 ADP-ribosylation factor-like 14
ARSD arylsulfatase D
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BCL6 B-cell CLL/lymphoma 6
C14ORF79 chromosome 14 open reading frame 79
CA5B carbonic anhydrase VB, mitochondrial
CCNG2 cyclin G2
CEP135 centrosomal protein 135kDa
CNKSR2 connector enhancer of kinase suppressor of Ras 2
COL14A1 collagen, type XIV, alpha 1
CRYAB crystallin, alpha B
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DGKE diacylglycerol kinase, epsilon 64kDa
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DSC2 desmocollin 2
EDRF1 erythroid differentiation regulatory factor 1
ETV1 ets variant 1
EYA3 EYA transcriptional coactivator and phosphatase 3
FBXL2 F-box and leucine-rich repeat protein 2
GAB1 GRB2-associated binding protein 1
GFER growth factor, augmenter of liver regeneration
GRB7 growth factor receptor-bound protein 7
GRM2 glutamate receptor, metabotropic 2
GSTM5 glutathione S-transferase mu 5
GUSBP3 glucuronidase, beta pseudogene 3
HBP1 HMG-box transcription factor 1
HIST1H1D histone cluster 1, H1d
HIST1H1T histone cluster 1, H1t
HIST1H2BC histone cluster 1, H2bc
HIST1H2BG histone cluster 1, H2bg
HIST3H2A histone cluster 3, H2a
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
IL6ST interleukin 6 signal transducer
IRS2 insulin receptor substrate 2
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KERA keratocan
KIAA1107 KIAA1107
KLHL24 kelch-like family member 24
LAMA2 laminin, alpha 2
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRRC37A3 leucine rich repeat containing 37, member A3
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAK male germ cell-associated kinase
MAP2 microtubule-associated protein 2
MAP2K5 mitogen-activated protein kinase kinase 5
MAPK8 mitogen-activated protein kinase 8
MED25 mediator complex subunit 25
MEGF6 multiple EGF-like-domains 6
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
N4BP1 NEDD4 binding protein 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NUMA1 nuclear mitotic apparatus protein 1
OR1G1 olfactory receptor, family 1, subfamily G, member 1
PCNX pecanex homolog (Drosophila)
PDE4B phosphodiesterase 4B, cAMP-specific
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLSCR4 phospholipid scramblase 4
PRKY protein kinase, Y-linked, pseudogene
PRMT2 protein arginine methyltransferase 2
PSORS1C1 psoriasis susceptibility 1 candidate 1
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RAD51 RAD51 recombinase
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RCE1 Ras converting CAAX endopeptidase 1
RET ret proto-oncogene
RNFT1 ring finger protein, transmembrane 1
RPS11 ribosomal protein S11
SEC14L5 SEC14-like 5 (S. cerevisiae)
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SF1 splicing factor 1
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
STON1 stonin 1
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TESK2 testis-specific kinase 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGIF1 TGFB-induced factor homeobox 1
TLN2 talin 2
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TTC12 tetratricopeptide repeat domain 12
USP53 ubiquitin specific peptidase 53
WSB1 WD repeat and SOCS box containing 1
YPEL1 yippee-like 1 (Drosophila)
ZBTB20 zinc finger and BTB domain containing 20
ZBTB7A zinc finger and BTB domain containing 7A

decreased expression

Symbol Name
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BEX1 brain expressed, X-linked 1
C3 complement component 3
CAPN15 calpain 15
CCDC86 coiled-coil domain containing 86
CDH7 cadherin 7, type 2
CHST10 carbohydrate sulfotransferase 10
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
COA7 cytochrome c oxidase assembly factor 7 (putative)
COL9A3 collagen, type IX, alpha 3
CPEB1 cytoplasmic polyadenylation element binding protein 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DDIT4 DNA-damage-inducible transcript 4
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DEAF1 DEAF1 transcription factor
DNAH7 dynein, axonemal, heavy chain 7
EFNA3 ephrin-A3
EPN3 epsin 3
FAM57A family with sequence similarity 57, member A
FBXO31 F-box protein 31
FCHO1 FCH domain only 1
FGFBP1 fibroblast growth factor binding protein 1
FZD8 frizzled class receptor 8
GLS2 glutaminase 2 (liver, mitochondrial)
H2AFY2 H2A histone family, member Y2
HAS2 hyaluronan synthase 2
HOXC13 homeobox C13
HSPB8 heat shock 22kDa protein 8
IFI44L interferon-induced protein 44-like
IL12A interleukin 12A
IL17RB interleukin 17 receptor B
INO80D INO80 complex subunit D
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KCTD14 potassium channel tetramerization domain containing 14
KLHL3 kelch-like family member 3
LIPG lipase, endothelial
LRRC61 leucine rich repeat containing 61
MDFI MyoD family inhibitor
METTL1 methyltransferase like 1
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRPL46 mitochondrial ribosomal protein L46
MTA2 metastasis associated 1 family, member 2
NDP Norrie disease (pseudoglioma)
NOP2 NOP2 nucleolar protein
NPR3 natriuretic peptide receptor 3
NR2F6 nuclear receptor subfamily 2, group F, member 6
NTSR1 neurotensin receptor 1 (high affinity)
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
OXTR oxytocin receptor
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PCOLCE procollagen C-endopeptidase enhancer
PES1 pescadillo ribosomal biogenesis factor 1
PLEKHO1 pleckstrin homology domain containing, family O member 1
POLM polymerase (DNA directed), mu
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
PPAN peter pan homolog (Drosophila)
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PUS1 pseudouridylate synthase 1
RABEPK Rab9 effector protein with kelch motifs
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX1-IT1 RUNX1 intronic transcript 1
SCGB2A2 secretoglobin, family 2A, member 2
SDC3 syndecan 3
SH2D2A SH2 domain containing 2A
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLITRK5 SLIT and NTRK-like family, member 5
SPHK1 sphingosine kinase 1
SPTBN2 spectrin, beta, non-erythrocytic 2
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TEAD4 TEA domain family member 4
THRAP3 thyroid hormone receptor associated protein 3
TMEM180 transmembrane protein 180
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TUBA3D tubulin, alpha 3d
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UGT8 UDP glycosyltransferase 8
USB1 U6 snRNA biogenesis 1
WDR46 WD repeat domain 46
WDR74 WD repeat domain 74
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZHX2 zinc fingers and homeoboxes 2
ZNF239 zinc finger protein 239
ZNF41 zinc finger protein 41
ZNF787 zinc finger protein 787