LY-294002-4440 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the LY-294002-4440 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACVR1B activin A receptor, type IB
AHSP alpha hemoglobin stabilizing protein
ALDOB aldolase B, fructose-bisphosphate
AQP4 aquaporin 4
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
ATP9A ATPase, class II, type 9A
CA1 carbonic anhydrase I
CD22 CD22 molecule
CD53 CD53 molecule
CDK20 cyclin-dependent kinase 20
CDO1 cysteine dioxygenase type 1
CDRT1 CMT1A duplicated region transcript 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEP162 centrosomal protein 162kDa
CHI3L2 chitinase 3-like 2
CHRDL1 chordin-like 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CNR2 cannabinoid receptor 2 (macrophage)
CRISP1 cysteine-rich secretory protein 1
CRP C-reactive protein, pentraxin-related
CRTAM cytotoxic and regulatory T cell molecule
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSHL1 chorionic somatomammotropin hormone-like 1
DIAPH2-AS1 DIAPH2 antisense RNA 1
DOCK10 dedicator of cytokinesis 10
DSG3 desmoglein 3
ELAVL3 ELAV like neuron-specific RNA binding protein 3
EXOSC1 exosome component 1
FAM134B family with sequence similarity 134, member B
FGB fibrinogen beta chain
FYB FYN binding protein
GATA4 GATA binding protein 4
GCGR glucagon receptor
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GP1BB glycoprotein Ib (platelet), beta polypeptide
GPR75 G protein-coupled receptor 75
HIST1H1T histone cluster 1, H1t
HOXB7 homeobox B7
HPX hemopexin
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IRF4 interferon regulatory factor 4
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KLF13 Kruppel-like factor 13
KLHL23 kelch-like family member 23
KLK3 kallikrein-related peptidase 3
LENEP lens epithelial protein
LIMS2 LIM and senescent cell antigen-like domains 2
MCF2L MCF.2 cell line derived transforming sequence-like
MED25 mediator complex subunit 25
MIER2 mesoderm induction early response 1, family member 2
MLANA melan-A
MLXIPL MLX interacting protein-like
MUC2 mucin 2, oligomeric mucus/gel-forming
N4BP2L1 NEDD4 binding protein 2-like 1
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NEUROD6 neuronal differentiation 6
NPTX1 neuronal pentraxin I
NR6A1 nuclear receptor subfamily 6, group A, member 1
OBSL1 obscurin-like 1
OCA2 oculocutaneous albinism II
PDCD6 programmed cell death 6
PDE8B phosphodiesterase 8B
PDLIM3 PDZ and LIM domain 3
PDPN podoplanin
PEX3 peroxisomal biogenesis factor 3
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PODNL1 podocan-like 1
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRKCA protein kinase C, alpha
PRPH2 peripherin 2 (retinal degeneration, slow)
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RUNX1 runt-related transcription factor 1
SCUBE3 signal peptide, CUB domain, EGF-like 3
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SORBS1 sorbin and SH3 domain containing 1
SPINK4 serine peptidase inhibitor, Kazal type 4
TAOK2 TAO kinase 2
TBX21 T-box 21
TENM1 teneurin transmembrane protein 1
TGM4 transglutaminase 4
TMPRSS15 transmembrane protease, serine 15
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae)
TSC22D4 TSC22 domain family, member 4
WDR1 WD repeat domain 1
ZIC3 Zic family member 3
ZNF362 zinc finger protein 362
ZNF384 zinc finger protein 384

decreased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ADGRB2 adhesion G protein-coupled receptor B2
AFF4 AF4/FMR2 family, member 4
ANKRD36 ankyrin repeat domain 36
APH1B APH1B gamma secretase subunit
ARSJ arylsulfatase family, member J
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BAG4 BCL2-associated athanogene 4
BAHCC1 BAH domain and coiled-coil containing 1
BATF3 basic leucine zipper transcription factor, ATF-like 3
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BEX1 brain expressed, X-linked 1
C17ORF53 chromosome 17 open reading frame 53
C1RL complement component 1, r subcomponent-like
C1S complement component 1, s subcomponent
CCNO cyclin O
CHM choroideremia (Rab escort protein 1)
CLCN5 chloride channel, voltage-sensitive 5
CLDN14 claudin 14
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CPEB1 cytoplasmic polyadenylation element binding protein 1
CRY2 cryptochrome circadian clock 2
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CXCL2 chemokine (C-X-C motif) ligand 2
DBF4B DBF4 zinc finger B
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
FBXO31 F-box protein 31
FPGS folylpolyglutamate synthase
FRS2 fibroblast growth factor receptor substrate 2
FSD1 fibronectin type III and SPRY domain containing 1
GLS2 glutaminase 2 (liver, mitochondrial)
GNA14 guanine nucleotide binding protein (G protein), alpha 14
HIST1H2AI histone cluster 1, H2ai
HIST1H2AM histone cluster 1, H2am
HIST1H4C histone cluster 1, H4c
HOXA4 homeobox A4
HSPA4L heat shock 70kDa protein 4-like
HYAL3 hyaluronoglucosaminidase 3
IFI6 interferon, alpha-inducible protein 6
IL11RA interleukin 11 receptor, alpha
IL12A interleukin 12A
IL33 interleukin 33
INCENP inner centromere protein antigens 135/155kDa
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KIRREL kin of IRRE like (Drosophila)
KLHL12 kelch-like family member 12
LMCD1 LIM and cysteine-rich domains 1
LOC100127972 uncharacterized LOC100127972
LRRC61 leucine rich repeat containing 61
MAP9 microtubule-associated protein 9
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MGMT O-6-methylguanine-DNA methyltransferase
MMP1 matrix metallopeptidase 1
MMP13 matrix metallopeptidase 13
MOCS3 molybdenum cofactor synthesis 3
MT1M metallothionein 1M
NCALD neurocalcin delta
NCF2 neutrophil cytosolic factor 2
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NID2 nidogen 2 (osteonidogen)
NOL12 nucleolar protein 12
NT5M 5',3'-nucleotidase, mitochondrial
OVGP1 oviductal glycoprotein 1, 120kDa
PAX9 paired box 9
PLAC8 placenta-specific 8
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PMCH pro-melanin-concentrating hormone
RAB33B RAB33B, member RAS oncogene family
RFTN1 raftlin, lipid raft linker 1
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCEL sciellin
SH2D2A SH2 domain containing 2A
SKI SKI proto-oncogene
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC46A3 solute carrier family 46, member 3
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SPATA2L spermatogenesis associated 2-like
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STK4 serine/threonine kinase 4
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TEX40 testis expressed 40
TM7SF2 transmembrane 7 superfamily member 2
TMC7 transmembrane channel-like 7
TMEM180 transmembrane protein 180
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TRPS1 trichorhinophalangeal syndrome I
TTC23 tetratricopeptide repeat domain 23
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UNC119 unc-119 homolog (C. elegans)
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZBTB6 zinc finger and BTB domain containing 6
ZC2HC1C zinc finger, C2HC-type containing 1C
ZNF141 zinc finger protein 141
ZNF711 zinc finger protein 711
ZNF862 zinc finger protein 862