LY-294002-424 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the LY-294002-424 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADAP1 ArfGAP with dual PH domains 1
AGBL5 ATP/GTP binding protein-like 5
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AP3D1 adaptor-related protein complex 3, delta 1 subunit
APOC1 apolipoprotein C-I
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ATF6 activating transcription factor 6
ATG13 autophagy related 13
ATP7B ATPase, Cu++ transporting, beta polypeptide
AXIN1 axin 1
BLMH bleomycin hydrolase
BRAP BRCA1 associated protein
C7ORF43 chromosome 7 open reading frame 43
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CD46 CD46 molecule, complement regulatory protein
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDV3 CDV3 homolog (mouse)
COG5 component of oligomeric golgi complex 5
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCTN2 dynactin 2 (p50)
DXO decapping exoribonuclease
E2F1 E2F transcription factor 1
EHD1 EH-domain containing 1
EHMT2 euchromatic histone-lysine N-methyltransferase 2
EMC1 ER membrane protein complex subunit 1
FKBP2 FK506 binding protein 2, 13kDa
FKBP8 FK506 binding protein 8, 38kDa
FXR2 fragile X mental retardation, autosomal homolog 2
GLMN glomulin, FKBP associated protein
GNA13 guanine nucleotide binding protein (G protein), alpha 13
HLA-G major histocompatibility complex, class I, G
HPSE heparanase
HSPA4 heat shock 70kDa protein 4
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
KAZN kazrin, periplakin interacting protein
KDM5A lysine (K)-specific demethylase 5A
KDM6B lysine (K)-specific demethylase 6B
KHNYN KH and NYN domain containing
L1CAM L1 cell adhesion molecule
LPP LIM domain containing preferred translocation partner in lipoma
MED28 mediator complex subunit 28
MPPE1 metallophosphoesterase 1
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MRPL57 mitochondrial ribosomal protein L57
MVK mevalonate kinase
NDRG2 NDRG family member 2
NPEPL1 aminopeptidase-like 1
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
OSBPL11 oxysterol binding protein-like 11
PAQR6 progestin and adipoQ receptor family member VI
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PEX13 peroxisomal biogenesis factor 13
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PKN2 protein kinase N2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLK4 polo-like kinase 4
POT1 protection of telomeres 1
PPAN peter pan homolog (Drosophila)
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPP2R2D protein phosphatase 2, regulatory subunit B, delta
RAB23 RAB23, member RAS oncogene family
RHOT2 ras homolog family member T2
RNF126 ring finger protein 126
S100PBP S100P binding protein
SDC2 syndecan 2
SFPQ splicing factor proline/glutamine-rich
SIKE1 suppressor of IKBKE 1
SMG7 SMG7 nonsense mediated mRNA decay factor
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa
SORT1 sortilin 1
SPN sialophorin
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRF serum response factor (c-fos serum response element-binding transcription factor)
SRSF1 serine/arginine-rich splicing factor 1
SS18 synovial sarcoma translocation, chromosome 18
STAT5A signal transducer and activator of transcription 5A
SUGP2 SURP and G patch domain containing 2
T T, brachyury homolog (mouse)
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TMED5 transmembrane emp24 protein transport domain containing 5
TMEM194A transmembrane protein 194A
TNPO3 transportin 3
TNS1 tensin 1
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TOR1AIP1 torsin A interacting protein 1
TRAFD1 TRAF-type zinc finger domain containing 1
TRIM62 tripartite motif containing 62
TSSC4 tumor suppressing subtransferable candidate 4
UBE4B ubiquitination factor E4B
UBL3 ubiquitin-like 3
UBQLN4 ubiquilin 4
VEGFB vascular endothelial growth factor B
VIM vimentin
VRK3 vaccinia related kinase 3
VWA9 von Willebrand factor A domain containing 9
WDR48 WD repeat domain 48
ZNF24 zinc finger protein 24

decreased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ACSL5 acyl-CoA synthetase long-chain family member 5
ADRA2C adrenoceptor alpha 2C
AEN apoptosis enhancing nuclease
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
AQP8 aquaporin 8
ART1 ADP-ribosyltransferase 1
ATXN2 ataxin 2
C1ORF159 chromosome 1 open reading frame 159
C2CD5 C2 calcium-dependent domain containing 5
C8ORF60 chromosome 8 open reading frame 60
C9ORF114 chromosome 9 open reading frame 114
CALB2 calbindin 2
CCDC25 coiled-coil domain containing 25
CD5 CD5 molecule
CD8A CD8a molecule
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CIDEB cell death-inducing DFFA-like effector b
CNGB3 cyclic nucleotide gated channel beta 3
CPB1 carboxypeptidase B1 (tissue)
CRYAB crystallin, alpha B
CSN2 casein beta
CTNNBIP1 catenin, beta interacting protein 1
CTRB2 chymotrypsinogen B2
CUZD1 CUB and zona pellucida-like domains 1
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
DAO D-amino-acid oxidase
DGKD diacylglycerol kinase, delta 130kDa
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
ERN2 endoplasmic reticulum to nucleus signaling 2
FGF6 fibroblast growth factor 6
FKTN fukutin
FLJ11710 uncharacterized protein FLJ11710
FSD1 fibronectin type III and SPRY domain containing 1
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GAST gastrin
GJD2 gap junction protein, delta 2, 36kDa
HIST1H2AI histone cluster 1, H2ai
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular)
IL2RG interleukin 2 receptor, gamma
INTS12 integrator complex subunit 12
JAM2 junctional adhesion molecule 2
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KIAA0513 KIAA0513
KRT32 keratin 32, type I
KRTAP1-1 keratin associated protein 1-1
LOC729164 hCG1732469
LONRF3 LON peptidase N-terminal domain and ring finger 3
LY6G6D lymphocyte antigen 6 complex, locus G6D
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MEGF6 multiple EGF-like-domains 6
MFGE8 milk fat globule-EGF factor 8 protein
MFSD11 major facilitator superfamily domain containing 11
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NEUROD2 neuronal differentiation 2
NEUROG1 neurogenin 1
NPPA natriuretic peptide A
ORC1 origin recognition complex, subunit 1
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
PARG poly (ADP-ribose) glycohydrolase
PARP16 poly (ADP-ribose) polymerase family, member 16
PES1 pescadillo ribosomal biogenesis factor 1
PF4 platelet factor 4
PHKG1 phosphorylase kinase, gamma 1 (muscle)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLEKHO2 pleckstrin homology domain containing, family O member 2
PODXL podocalyxin-like
PRAME preferentially expressed antigen in melanoma
PTTG3P pituitary tumor-transforming 3, pseudogene
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
RBP1 retinol binding protein 1, cellular
RLBP1 retinaldehyde binding protein 1
RNF39 ring finger protein 39
RORC RAR-related orphan receptor C
RSG1 REM2 and RAB-like small GTPase 1
SKAP1 src kinase associated phosphoprotein 1
SLC17A4 solute carrier family 17, member 4
SLC35F2 solute carrier family 35, member F2
SNTA1 syntrophin, alpha 1
SOD3 superoxide dismutase 3, extracellular
SPX spexin hormone
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TM4SF5 transmembrane 4 L six family member 5
TMEM110 transmembrane protein 110
TMEM204 transmembrane protein 204
TMEM242 transmembrane protein 242
TNNT1 troponin T type 1 (skeletal, slow)
USP29 ubiquitin specific peptidase 29
WDR19 WD repeat domain 19
XPC xeroderma pigmentosum, complementation group C
ZMYM1 zinc finger, MYM-type 1
ZNF354A zinc finger protein 354A
ZNF652 zinc finger protein 652
ZNF669 zinc finger protein 669
ZNHIT2 zinc finger, HIT-type containing 2