LY-294002-401 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the LY-294002-401 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSL6 acyl-CoA synthetase long-chain family member 6
ACVR1B activin A receptor, type IB
ADH6 alcohol dehydrogenase 6 (class V)
ADRA2B adrenoceptor alpha 2B
AMPH amphiphysin
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BMP8B bone morphogenetic protein 8b
C1ORF61 chromosome 1 open reading frame 61
C4ORF29 chromosome 4 open reading frame 29
C8B complement component 8, beta polypeptide
CA6 carbonic anhydrase VI
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCPG1 cell cycle progression 1
CD5 CD5 molecule
CD6 CD6 molecule
CD82 CD82 molecule
CD86 CD86 molecule
CD8B CD8b molecule
CHD2 chromodomain helicase DNA binding protein 2
CLCN6 chloride channel, voltage-sensitive 6
COPZ2 coatomer protein complex, subunit zeta 2
CRYAB crystallin, alpha B
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
DCSTAMP dendrocyte expressed seven transmembrane protein
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DEFA4 defensin, alpha 4, corticostatin
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DUS2 dihydrouridine synthase 2
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EGR1 early growth response 1
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
ELK1 ELK1, member of ETS oncogene family
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ESR2 estrogen receptor 2 (ER beta)
FAM149B1 family with sequence similarity 149, member B1
FBXO41 F-box protein 41
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGL1 fibrinogen-like 1
FLOT1 flotillin 1
FN1 fibronectin 1
FOLR2 folate receptor 2 (fetal)
GOSR2 golgi SNAP receptor complex member 2
GREM1 gremlin 1, DAN family BMP antagonist
HAP1 huntingtin-associated protein 1
HMX1 H6 family homeobox 1
HOXB1 homeobox B1
IFNA4 interferon, alpha 4
IL2RG interleukin 2 receptor, gamma
INA internexin neuronal intermediate filament protein, alpha
KIFAP3 kinesin-associated protein 3
KLHL24 kelch-like family member 24
KLHL28 kelch-like family member 28
LIMS2 LIM and senescent cell antigen-like domains 2
LINC01558 long intergenic non-protein coding RNA 1558
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LRRC23 leucine rich repeat containing 23
LTBP4 latent transforming growth factor beta binding protein 4
MAGEA5 melanoma antigen family A5
MAGEB2 melanoma antigen family B2
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MST1 macrophage stimulating 1
MYO15B myosin XVB
MYOG myogenin (myogenic factor 4)
N4BP2L1 NEDD4 binding protein 2-like 1
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OR12D3 olfactory receptor, family 12, subfamily D, member 3
OR52A1 olfactory receptor, family 52, subfamily A, member 1
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLIN2 perilipin 2
PMEPA1 prostate transmembrane protein, androgen induced 1
PROP1 PROP paired-like homeobox 1
PRSS3 protease, serine, 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB11B RAB11B, member RAS oncogene family
RGSL1 regulator of G-protein signaling like 1
RNMT RNA (guanine-7-) methyltransferase
SAG S-antigen; retina and pineal gland (arrestin)
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SERHL2 serine hydrolase-like 2
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC45A2 solute carrier family 45, member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPON1 spondin 1, extracellular matrix protein
SSTR2 somatostatin receptor 2
SYNDIG1 synapse differentiation inducing 1
TCP11 t-complex 11, testis-specific
TLL2 tolloid-like 2
TRAC T cell receptor alpha constant
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TYMP thymidine phosphorylase
ULK2 unc-51 like autophagy activating kinase 2
USF2 upstream transcription factor 2, c-fos interacting
WNT2B wingless-type MMTV integration site family, member 2B
ZNF460 zinc finger protein 460

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ADGRB2 adhesion G protein-coupled receptor B2
ADORA2B adenosine A2b receptor
ADRA2C adrenoceptor alpha 2C
ANKRD40 ankyrin repeat domain 40
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATXN2 ataxin 2
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C16ORF59 chromosome 16 open reading frame 59
C4BPA complement component 4 binding protein, alpha
CDC45 cell division cycle 45
CDK3 cyclin-dependent kinase 3
CHML choroideremia-like (Rab escort protein 2)
CLDN17 claudin 17
CORT cortistatin
CRY1 cryptochrome circadian clock 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DAGLA diacylglycerol lipase, alpha
DCLRE1A DNA cross-link repair 1A
DDA1 DET1 and DDB1 associated 1
DOK3 docking protein 3
EHD3 EH-domain containing 3
ENDOG endonuclease G
EXOSC10 exosome component 10
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM188A family with sequence similarity 188, member A
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FOXD1 forkhead box D1
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FSD1 fibronectin type III and SPRY domain containing 1
GDF3 growth differentiation factor 3
GMEB1 glucocorticoid modulatory element binding protein 1
GMIP GEM interacting protein
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPR19 G protein-coupled receptor 19
HMHA1 histocompatibility (minor) HA-1
IFT81 intraflagellar transport 81
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IL25 interleukin 25
IL4R interleukin 4 receptor
ITPKB inositol-trisphosphate 3-kinase B
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KIF20B kinesin family member 20B
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KREMEN2 kringle containing transmembrane protein 2
LGMN legumain
LTBP3 latent transforming growth factor beta binding protein 3
MAGOHB mago-nashi homolog B (Drosophila)
MDK midkine (neurite growth-promoting factor 2)
MTRF1 mitochondrial translational release factor 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NCS1 neuronal calcium sensor 1
NKAIN1 Na+/K+ transporting ATPase interacting 1
NOL6 nucleolar protein 6 (RNA-associated)
NRGN neurogranin (protein kinase C substrate, RC3)
OLFML2A olfactomedin-like 2A
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PAK1IP1 PAK1 interacting protein 1
PCDHB12 protocadherin beta 12
PES1 pescadillo ribosomal biogenesis factor 1
PGBD5 piggyBac transposable element derived 5
PHLDA2 pleckstrin homology-like domain, family A, member 2
PTK6 protein tyrosine kinase 6
RAB23 RAB23, member RAS oncogene family
RAB8B RAB8B, member RAS oncogene family
RAD54L RAD54-like (S. cerevisiae)
RAI14 retinoic acid induced 14
RNF121 ring finger protein 121
RORC RAR-related orphan receptor C
RPS17P5 ribosomal protein S17 pseudogene 5
RPS4Y1 ribosomal protein S4, Y-linked 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SMYD5 SMYD family member 5
SNCB synuclein, beta
SPINK4 serine peptidase inhibitor, Kazal type 4
STARD8 StAR-related lipid transfer (START) domain containing 8
T T, brachyury homolog (mouse)
TCEA2 transcription elongation factor A (SII), 2
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMEM127 transmembrane protein 127
TMEM53 transmembrane protein 53
TRAF2 TNF receptor-associated factor 2
TTR transthyretin
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WDR13 WD repeat domain 13
WDR18 WD repeat domain 18
WDR46 WD repeat domain 46
WDR91 WD repeat domain 91
WT1-AS WT1 antisense RNA
WWC2 WW and C2 domain containing 2
ZFP36 ZFP36 ring finger protein
ZNF701 zinc finger protein 701