LY-294002-361 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the LY-294002-361 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
ACP6 acid phosphatase 6, lysophosphatidic
AIM2 absent in melanoma 2
AQP3 aquaporin 3 (Gill blood group)
AQP6 aquaporin 6, kidney specific
ASTE1 asteroid homolog 1 (Drosophila)
ATG13 autophagy related 13
C10ORF12 chromosome 10 open reading frame 12
C7ORF43 chromosome 7 open reading frame 43
CA12 carbonic anhydrase XII
CA6 carbonic anhydrase VI
CADM3 cell adhesion molecule 3
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CBX8 chromobox homolog 8
CBY1 chibby homolog 1 (Drosophila)
CCND1 cyclin D1
CD5 CD5 molecule
CD8A CD8a molecule
CEP72 centrosomal protein 72kDa
CLDN17 claudin 17
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae)
DNAH3 dynein, axonemal, heavy chain 3
DRD2 dopamine receptor D2
ELF4 E74-like factor 4 (ets domain transcription factor)
EPX eosinophil peroxidase
ERMP1 endoplasmic reticulum metallopeptidase 1
FANCF Fanconi anemia, complementation group F
FGFBP1 fibroblast growth factor binding protein 1
FGFR1 fibroblast growth factor receptor 1
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GJB3 gap junction protein, beta 3, 31kDa
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
HUS1 HUS1 checkpoint homolog (S. pombe)
IFT122 intraflagellar transport 122
ING4 inhibitor of growth family, member 4
INSL4 insulin-like 4 (placenta)
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KLF15 Kruppel-like factor 15
KLHL25 kelch-like family member 25
LARP1 La ribonucleoprotein domain family, member 1
LINC00339 long intergenic non-protein coding RNA 339
MAOA monoamine oxidase A
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MASP2 mannan-binding lectin serine peptidase 2
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MZF1 myeloid zinc finger 1
N4BP2L2 NEDD4 binding protein 2-like 2
NEK9 NIMA-related kinase 9
NKIRAS2 NFKB inhibitor interacting Ras-like 2
NPFF neuropeptide FF-amide peptide precursor
NRG1 neuregulin 1
OCRL oculocerebrorenal syndrome of Lowe
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PARVA parvin, alpha
PDPK1 3-phosphoinositide dependent protein kinase 1
PELP1 proline, glutamate and leucine rich protein 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
POPDC2 popeye domain containing 2
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRKCE protein kinase C, epsilon
PRPF18 pre-mRNA processing factor 18
RAB26 RAB26, member RAS oncogene family
RAB33B RAB33B, member RAS oncogene family
RAB4B RAB4B, member RAS oncogene family
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RLBP1 retinaldehyde binding protein 1
RUNDC3A RUN domain containing 3A
SAP30 Sin3A-associated protein, 30kDa
SCYL3 SCY1-like 3 (S. cerevisiae)
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
SH3GL3 SH3-domain GRB2-like 3
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SNX6 sorting nexin 6
SPDEF SAM pointed domain containing ETS transcription factor
SSX3 synovial sarcoma, X breakpoint 3
STX2 syntaxin 2
SYNPO synaptopodin
TFE3 transcription factor binding to IGHM enhancer 3
TMEM127 transmembrane protein 127
TMEM176A transmembrane protein 176A
TMEM63A transmembrane protein 63A
TMPRSS2 transmembrane protease, serine 2
TP63 tumor protein p63
TRIM33 tripartite motif containing 33
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
YLPM1 YLP motif containing 1
ZC3H13 zinc finger CCCH-type containing 13
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF219 zinc finger protein 219
ZNF287 zinc finger protein 287
ZNF473 zinc finger protein 473
ZNF93 zinc finger protein 93

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
AEN apoptosis enhancing nuclease
APOL6 apolipoprotein L, 6
ARG1 arginase 1
ARL4A ADP-ribosylation factor-like 4A
ARRB1 arrestin, beta 1
BIK BCL2-interacting killer (apoptosis-inducing)
BRIX1 BRX1, biogenesis of ribosomes
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C4BPA complement component 4 binding protein, alpha
CAV3 caveolin 3
CCDC86 coiled-coil domain containing 86
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CD151 CD151 molecule (Raph blood group)
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3
DRAM1 DNA-damage regulated autophagy modulator 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMC9 ER membrane protein complex subunit 9
EMG1 EMG1 N1-specific pseudouridine methyltransferase
FAM189B family with sequence similarity 189, member B
FTCD formimidoyltransferase cyclodeaminase
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GAR1 GAR1 ribonucleoprotein
GDF5 growth differentiation factor 5
GMEB1 glucocorticoid modulatory element binding protein 1
HSPB1 heat shock 27kDa protein 1
HSPE1 heat shock 10kDa protein 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
ITGB7 integrin, beta 7
JOSD1 Josephin domain containing 1
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KLHL3 kelch-like family member 3
LMO3 LIM domain only 3 (rhombotin-like 2)
LOC390998 ribosomal protein L10 pseudogene
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRRC16A leucine rich repeat containing 16A
MB myoglobin
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MSMO1 methylsterol monooxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAT10 N-acetyltransferase 10 (GCN5-related)
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
NELL2 NEL-like 2 (chicken)
NOL6 nucleolar protein 6 (RNA-associated)
NXPH3 neurexophilin 3
OR7A17 olfactory receptor, family 7, subfamily A, member 17
ORM1 orosomucoid 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAK1IP1 PAK1 interacting protein 1
PARG poly (ADP-ribose) glycohydrolase
PCDHA9 protocadherin alpha 9
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PFAS phosphoribosylformylglycinamidine synthase
PHACTR1 phosphatase and actin regulator 1
PID1 phosphotyrosine interaction domain containing 1
PLEK2 pleckstrin 2
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPP1R17 protein phosphatase 1, regulatory subunit 17
PPP4C protein phosphatase 4, catalytic subunit
PRDX4 peroxiredoxin 4
PRTN3 proteinase 3
PRY PTPN13-like, Y-linked
PTPRT protein tyrosine phosphatase, receptor type, T
PUS7 pseudouridylate synthase 7 (putative)
QTRT1 queuine tRNA-ribosyltransferase 1
RHOH ras homolog family member H
RPAP2 RNA polymerase II associated protein 2
RRP7A ribosomal RNA processing 7 homolog A (S. cerevisiae)
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SETD6 SET domain containing 6
SLC16A6 solute carrier family 16, member 6
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLIT2 slit homolog 2 (Drosophila)
SLPI secretory leukocyte peptidase inhibitor
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
STAB2 stabilin 2
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TJP2 tight junction protein 2
TMEM147 transmembrane protein 147
TRABD TraB domain containing
TTC27 tetratricopeptide repeat domain 27
UCK2 uridine-cytidine kinase 2
UNC93B1 unc-93 homolog B1 (C. elegans)
VASP vasodilator-stimulated phosphoprotein
WDR46 WD repeat domain 46
ZC3H12A zinc finger CCCH-type containing 12A
ZNF185 zinc finger protein 185 (LIM domain)