LY-294002-1180 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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200 genes differentially expressed following the LY-294002-1180 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACACB acetyl-CoA carboxylase beta
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
APAF1 apoptotic peptidase activating factor 1
APOLD1 apolipoprotein L domain containing 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATP9B ATPase, class II, type 9B
ATRX alpha thalassemia/mental retardation syndrome X-linked
BACE1 beta-site APP-cleaving enzyme 1
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BIN3 bridging integrator 3
BTG2 BTG family, member 2
CCDC170 coiled-coil domain containing 170
CCL20 chemokine (C-C motif) ligand 20
CCSER2 coiled-coil serine-rich protein 2
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CD59 CD59 molecule, complement regulatory protein
CD86 CD86 molecule
CLCA1 chloride channel accessory 1
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
CREM cAMP responsive element modulator
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CUX1 cut-like homeobox 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DDAH2 dimethylarginine dimethylaminohydrolase 2
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAL4 dynein, axonemal, light chain 4
EGR3 early growth response 3
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F11R F11 receptor
FAM127A family with sequence similarity 127, member A
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
HIST1H2AC histone cluster 1, H2ac
HIST1H2AG histone cluster 1, H2ag
HIST1H2BG histone cluster 1, H2bg
IL6ST interleukin 6 signal transducer
ING1 inhibitor of growth family, member 1
ING4 inhibitor of growth family, member 4
INTS5 integrator complex subunit 5
IQCC IQ motif containing C
KDM4C lysine (K)-specific demethylase 4C
KLHL24 kelch-like family member 24
KRCC1 lysine-rich coiled-coil 1
KRT81 keratin 81, type II
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LMF2 lipase maturation factor 2
LOC642236 FSHD region gene 1 pseudogene
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K6 mitogen-activated protein kinase kinase 6
MED20 mediator complex subunit 20
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MTMR12 myotubularin related protein 12
N4BP2L2 NEDD4 binding protein 2-like 2
NAT6 N-acetyltransferase 6 (GCN5-related)
NCOA1 nuclear receptor coactivator 1
NCOA3 nuclear receptor coactivator 3
NPM3 nucleophosmin/nucleoplasmin 3
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PAOX polyamine oxidase (exo-N4-amino)
PARD3 par-3 family cell polarity regulator
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCGF2 polycomb group ring finger 2
PDE4B phosphodiesterase 4B, cAMP-specific
PGP phosphoglycolate phosphatase
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLK3 polo-like kinase 3
PLK4 polo-like kinase 4
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PWAR5 Prader Willi/Angelman region RNA 5
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
SCAI suppressor of cancer cell invasion
SGPL1 sphingosine-1-phosphate lyase 1
SGSM3 small G protein signaling modulator 3
SIGLEC9 sialic acid binding Ig-like lectin 9
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STAT2 signal transducer and activator of transcription 2, 113kDa
STS steroid sulfatase (microsomal), isozyme S
STX5 syntaxin 5
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMEM184C transmembrane protein 184C
TSC22D3 TSC22 domain family, member 3
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae)
XAB2 XPA binding protein 2
ZC3H7B zinc finger CCCH-type containing 7B
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF250 zinc finger protein 250

decreased expression

Symbol Name
ACTR5 ARP5 actin-related protein 5 homolog (yeast)
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AHCTF1 AT hook containing transcription factor 1
ANKRD55 ankyrin repeat domain 55
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ARMC7 armadillo repeat containing 7
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
AURKB aurora kinase B
BATF3 basic leucine zipper transcription factor, ATF-like 3
C16ORF59 chromosome 16 open reading frame 59
C2CD2 C2 calcium-dependent domain containing 2
CAPN15 calpain 15
CBX4 chromobox homolog 4
CCDC86 coiled-coil domain containing 86
CGREF1 cell growth regulator with EF-hand domain 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN15 claudin 15
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae)
CRIP1 cysteine-rich protein 1 (intestinal)
CTNNBL1 catenin, beta like 1
CTSG cathepsin G
DENND2D DENN/MADD domain containing 2D
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DHRS9 dehydrogenase/reductase (SDR family) member 9
DKK2 dickkopf WNT signaling pathway inhibitor 2
ERCC2 excision repair cross-complementation group 2
ERN2 endoplasmic reticulum to nucleus signaling 2
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
F3 coagulation factor III (thromboplastin, tissue factor)
FBXL7 F-box and leucine-rich repeat protein 7
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FMNL1 formin-like 1
FOXN2 forkhead box N2
FYCO1 FYVE and coiled-coil domain containing 1
GOLGA3 golgin A3
GTPBP6 GTP binding protein 6 (putative)
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
INHBE inhibin, beta E
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
KCNK5 potassium channel, two pore domain subfamily K, member 5
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MDN1 MDN1, midasin homolog (yeast)
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MID1IP1 MID1 interacting protein 1
MILR1 mast cell immunoglobulin-like receptor 1
MOGS mannosyl-oligosaccharide glucosidase
MREG melanoregulin
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL4 mitochondrial ribosomal protein L4
NARFL nuclear prelamin A recognition factor-like
NME6 NME/NM23 nucleoside diphosphate kinase 6
NRGN neurogranin (protein kinase C substrate, RC3)
NSUN3 NOP2/Sun domain family, member 3
PCOLCE2 procollagen C-endopeptidase enhancer 2
PELP1 proline, glutamate and leucine rich protein 1
PIEZO1 piezo-type mechanosensitive ion channel component 1
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PPARG peroxisome proliferator-activated receptor gamma
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PRAF2 PRA1 domain family, member 2
PRMT1 protein arginine methyltransferase 1
PRTN3 proteinase 3
PUS7 pseudouridylate synthase 7 (putative)
PYCR1 pyrroline-5-carboxylate reductase 1
QTRT1 queuine tRNA-ribosyltransferase 1
RAD54L2 RAD54-like 2 (S. cerevisiae)
REEP4 receptor accessory protein 4
RETSAT retinol saturase (all-trans-retinol 13,14-reductase)
RGS13 regulator of G-protein signaling 13
RNF31 ring finger protein 31
RSAD1 radical S-adenosyl methionine domain containing 1
SDCCAG3 serologically defined colon cancer antigen 3
SEC31B SEC31 homolog B (S. cerevisiae)
SFXN1 sideroflexin 1
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SND1-IT1 SND1 intronic transcript 1
SPRYD7 SPRY domain containing 7
SREK1IP1 SREK1-interacting protein 1
TERT telomerase reverse transcriptase
TM7SF3 transmembrane 7 superfamily member 3
TMEM209 transmembrane protein 209
TPRA1 transmembrane protein, adipocyte asscociated 1
TRDMT1 tRNA aspartic acid methyltransferase 1
TRIM9 tripartite motif containing 9
UPB1 ureidopropionase, beta
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VANGL1 VANGL planar cell polarity protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZNF212 zinc finger protein 212
ZNF529 zinc finger protein 529
ZNF675 zinc finger protein 675
ZSCAN5A zinc finger and SCAN domain containing 5A