LY-294002-1077 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the LY-294002-1077 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADARB1 adenosine deaminase, RNA-specific, B1
ADCK3 aarF domain containing kinase 3
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ATG13 autophagy related 13
ATG2B autophagy related 2B
AZI2 5-azacytidine induced 2
BCL6 B-cell CLL/lymphoma 6
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRD8 bromodomain containing 8
BRWD1 bromodomain and WD repeat domain containing 1
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CALCOCO1 calcium binding and coiled-coil domain 1
CALHM2 calcium homeostasis modulator 2
CAPN15 calpain 15
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CDK19 cyclin-dependent kinase 19
ETHE1 ethylmalonic encephalopathy 1
FBXL2 F-box and leucine-rich repeat protein 2
GRB7 growth factor receptor-bound protein 7
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HEMK1 HemK methyltransferase family member 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2AG histone cluster 1, H2ag
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H3B histone cluster 1, H3b
HIST1H3G histone cluster 1, H3g
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HIST3H2A histone cluster 3, H2a
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
ICK intestinal cell (MAK-like) kinase
INF2 inverted formin, FH2 and WH2 domain containing
ING4 inhibitor of growth family, member 4
INSR insulin receptor
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM4A lysine (K)-specific demethylase 4A
KDSR 3-ketodihydrosphingosine reductase
KIAA0141 KIAA0141
KIAA0430 KIAA0430
KLHL24 kelch-like family member 24
LGALS8 lectin, galactoside-binding, soluble, 8
MBD1 methyl-CpG binding domain protein 1
MT1G metallothionein 1G
MXD3 MAX dimerization protein 3
MXD4 MAX dimerization protein 4
MXI1 MAX interactor 1, dimerization protein
NBR1 neighbor of BRCA1 gene 1
NPM3 nucleophosmin/nucleoplasmin 3
NR2C2 nuclear receptor subfamily 2, group C, member 2
NUMA1 nuclear mitotic apparatus protein 1
OGG1 8-oxoguanine DNA glycosylase
PAQR6 progestin and adipoQ receptor family member VI
PCIF1 PDX1 C-terminal inhibiting factor 1
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PCYOX1L prenylcysteine oxidase 1 like
PDLIM7 PDZ and LIM domain 7 (enigma)
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PNRC1 proline-rich nuclear receptor coactivator 1
PRMT2 protein arginine methyltransferase 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTTG3P pituitary tumor-transforming 3, pseudogene
RALGDS ral guanine nucleotide dissociation stimulator
REST RE1-silencing transcription factor
RNF31 ring finger protein 31
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RSRP1 arginine/serine-rich protein 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SESN1 sestrin 1
SH3BGR SH3 domain binding glutamate-rich protein
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC38A2 solute carrier family 38, member 2
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TMCO6 transmembrane and coiled-coil domains 6
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIM66 tripartite motif containing 66
TRIO trio Rho guanine nucleotide exchange factor
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TTLL1 tubulin tyrosine ligase-like family member 1
TXNIP thioredoxin interacting protein
VRK3 vaccinia related kinase 3
WDR19 WD repeat domain 19
WEE1 WEE1 G2 checkpoint kinase
YPEL1 yippee-like 1 (Drosophila)
YPEL5 yippee-like 5 (Drosophila)
ZFYVE26 zinc finger, FYVE domain containing 26

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
ARPC5L actin related protein 2/3 complex, subunit 5-like
AUP1 ancient ubiquitous protein 1
BAG2 BCL2-associated athanogene 2
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
BRMS1 breast cancer metastasis suppressor 1
C12ORF4 chromosome 12 open reading frame 4
C9ORF91 chromosome 9 open reading frame 91
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CBR1 carbonyl reductase 1
CCDC86 coiled-coil domain containing 86
CCNE1 cyclin E1
CCNJ cyclin J
CLDN9 claudin 9
COA7 cytochrome c oxidase assembly factor 7 (putative)
CTPS1 CTP synthase 1
CXCL12 chemokine (C-X-C motif) ligand 12
DBR1 debranching RNA lariats 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
E2F8 E2F transcription factor 8
EGR3 early growth response 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM189B family with sequence similarity 189, member B
FAM216A family with sequence similarity 216, member A
FASTKD5 FAST kinase domains 5
FBXW4 F-box and WD repeat domain containing 4
FHOD1 formin homology 2 domain containing 1
FJX1 four jointed box 1 (Drosophila)
FPGS folylpolyglutamate synthase
GCC1 GRIP and coiled-coil domain containing 1
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GHR growth hormone receptor
GINS1 GINS complex subunit 1 (Psf1 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GNA12 guanine nucleotide binding protein (G protein) alpha 12
HSPA2 heat shock 70kDa protein 2
IER3 immediate early response 3
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
ISG15 ISG15 ubiquitin-like modifier
KLK6 kallikrein-related peptidase 6
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
MCRS1 microspherule protein 1
MED22 mediator complex subunit 22
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYBBP1A MYB binding protein (P160) 1a
MYD88 myeloid differentiation primary response 88
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NABP2 nucleic acid binding protein 2
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NES nestin
NIP7 NIP7, nucleolar pre-rRNA processing protein
NME7 NME/NM23 family member 7
NOP2 NOP2 nucleolar protein
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PHACTR4 phosphatase and actin regulator 4
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PLEKHO1 pleckstrin homology domain containing, family O member 1
PNP purine nucleoside phosphorylase
PP14571 uncharacterized LOC100130449
PRPF38B pre-mRNA processing factor 38B
PRR7 proline rich 7 (synaptic)
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
RAI14 retinoic acid induced 14
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RGS19 regulator of G-protein signaling 19
RHOBTB1 Rho-related BTB domain containing 1
RPP25 ribonuclease P/MRP 25kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SARS2 seryl-tRNA synthetase 2, mitochondrial
SFN stratifin
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SPAG1 sperm associated antigen 1
SPC25 SPC25, NDC80 kinetochore complex component
SRP19 signal recognition particle 19kDa
SUSD4 sushi domain containing 4
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TIPIN TIMELESS interacting protein
TMEM109 transmembrane protein 109
TRIM16 tripartite motif containing 16
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
WDR43 WD repeat domain 43
ZHX2 zinc fingers and homeoboxes 2
ZIC1 Zic family member 1
ZNF253 zinc finger protein 253
ZNF593 zinc finger protein 593
ZNF652 zinc finger protein 652
ZNF672 zinc finger protein 672
ZNF721 zinc finger protein 721