LY-294002-1074 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the LY-294002-1074 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ADCK3 aarF domain containing kinase 3
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ATG13 autophagy related 13
ATG2B autophagy related 2B
ATP9A ATPase, class II, type 9A
BCL6 B-cell CLL/lymphoma 6
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRD8 bromodomain containing 8
BRWD1 bromodomain and WD repeat domain containing 1
BTG1 B-cell translocation gene 1, anti-proliferative
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CFD complement factor D (adipsin)
CHKB choline kinase beta
CRIPT cysteine-rich PDZ-binding protein
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FAM149B1 family with sequence similarity 149, member B1
FAM63A family with sequence similarity 63, member A
FOXN3 forkhead box N3
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45A growth arrest and DNA-damage-inducible, alpha
GLS glutaminase
GRB7 growth factor receptor-bound protein 7
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HIST1H2AC histone cluster 1, H2ac
HIST1H2AG histone cluster 1, H2ag
HIST1H2AM histone cluster 1, H2am
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HIST3H2A histone cluster 3, H2a
ING4 inhibitor of growth family, member 4
INSR insulin receptor
IRS2 insulin receptor substrate 2
ITPKC inositol-trisphosphate 3-kinase C
KDM3A lysine (K)-specific demethylase 3A
KDSR 3-ketodihydrosphingosine reductase
KIAA0430 KIAA0430
KIZ kizuna centrosomal protein
KLF5 Kruppel-like factor 5 (intestinal)
KLF7 Kruppel-like factor 7 (ubiquitous)
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
LGALS8 lectin, galactoside-binding, soluble, 8
MANBA mannosidase, beta A, lysosomal
MED23 mediator complex subunit 23
MED9 mediator complex subunit 9
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MNT MAX network transcriptional repressor
MXD3 MAX dimerization protein 3
MXD4 MAX dimerization protein 4
MXI1 MAX interactor 1, dimerization protein
N4BP2L2 NEDD4 binding protein 2-like 2
NBR1 neighbor of BRCA1 gene 1
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NUMA1 nuclear mitotic apparatus protein 1
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PCYOX1L prenylcysteine oxidase 1 like
PINK1 PTEN induced putative kinase 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PXN paxillin
RBM48 RNA binding motif protein 48
REPS2 RALBP1 associated Eps domain containing 2
RETSAT retinol saturase (all-trans-retinol 13,14-reductase)
RNF31 ring finger protein 31
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RTN2 reticulon 2
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC35E2 solute carrier family 35, member E2
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
STON1 stonin 1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMCO6 transmembrane and coiled-coil domains 6
TXNIP thioredoxin interacting protein
UBE2H ubiquitin-conjugating enzyme E2H
VRK3 vaccinia related kinase 3
WDR19 WD repeat domain 19
WDR48 WD repeat domain 48
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
YPEL5 yippee-like 5 (Drosophila)
ZNF211 zinc finger protein 211
ZNF580 zinc finger protein 580

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ADORA2B adenosine A2b receptor
ALAS1 5'-aminolevulinate synthase 1
ARMC7 armadillo repeat containing 7
ARMCX5 armadillo repeat containing, X-linked 5
ATAD2B ATPase family, AAA domain containing 2B
ATAD5 ATPase family, AAA domain containing 5
BAG2 BCL2-associated athanogene 2
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C12ORF4 chromosome 12 open reading frame 4
C1ORF106 chromosome 1 open reading frame 106
C1ORF216 chromosome 1 open reading frame 216
C2CD2 C2 calcium-dependent domain containing 2
CCDC86 coiled-coil domain containing 86
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKAP4 cytoskeleton-associated protein 4
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CTPS1 CTP synthase 1
CUTC cutC copper transporter
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DBR1 debranching RNA lariats 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EFNA1 ephrin-A1
EHD3 EH-domain containing 3
ENDOD1 endonuclease domain containing 1
EXOSC9 exosome component 9
FA2H fatty acid 2-hydroxylase
FAM57A family with sequence similarity 57, member A
FASTKD1 FAST kinase domains 1
FASTKD5 FAST kinase domains 5
FHOD1 formin homology 2 domain containing 1
FKBP5 FK506 binding protein 5
GATAD2A GATA zinc finger domain containing 2A
GCC1 GRIP and coiled-coil domain containing 1
GHR growth hormone receptor
GINS1 GINS complex subunit 1 (Psf1 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GMPS guanine monphosphate synthase
H2AFY2 H2A histone family, member Y2
HEATR3 HEAT repeat containing 3
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HRAS Harvey rat sarcoma viral oncogene homolog
HSPA4L heat shock 70kDa protein 4-like
IER3 immediate early response 3
IL10RB interleukin 10 receptor, beta
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRRC42 leucine rich repeat containing 42
MAK16 MAK16 homolog (S. cerevisiae)
MARC1 mitochondrial amidoxime reducing component 1
MAT2A methionine adenosyltransferase II, alpha
METTL16 methyltransferase like 16
METTL18 methyltransferase like 18
MID1IP1 MID1 interacting protein 1
MRPL17 mitochondrial ribosomal protein L17
MT1HL1 metallothionein 1H-like 1
MYD88 myeloid differentiation primary response 88
NABP2 nucleic acid binding protein 2
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLEKHO1 pleckstrin homology domain containing, family O member 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAN peter pan homolog (Drosophila)
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRMT7 protein arginine methyltransferase 7
PRR7 proline rich 7 (synaptic)
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RAI14 retinoic acid induced 14
REPIN1 replication initiator 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SFN stratifin
SH2B2 SH2B adaptor protein 2
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMAGP small cell adhesion glycoprotein
SPAG1 sperm associated antigen 1
STRA13 stimulated by retinoic acid 13
SUSD4 sushi domain containing 4
TET3 tet methylcytosine dioxygenase 3
TOE1 target of EGR1, member 1 (nuclear)
TP53I3 tumor protein p53 inducible protein 3
TRMT61B tRNA methyltransferase 61B
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
WDR46 WD repeat domain 46
ZNF574 zinc finger protein 574
ZNF593 zinc finger protein 593
ZNF787 zinc finger protein 787