LY-294002-1007 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the LY-294002-1007 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADARB1 adenosine deaminase, RNA-specific, B1
ADCK3 aarF domain containing kinase 3
AKAP9 A kinase (PRKA) anchor protein 9
ALOX15 arachidonate 15-lipoxygenase
AMPD1 adenosine monophosphate deaminase 1
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANKZF1 ankyrin repeat and zinc finger domain containing 1
APOLD1 apolipoprotein L domain containing 1
BCL6 B-cell CLL/lymphoma 6
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C14ORF93 chromosome 14 open reading frame 93
C1QTNF3 C1q and tumor necrosis factor related protein 3
CALCOCO1 calcium binding and coiled-coil domain 1
CARF calcium responsive transcription factor
CBX7 chromobox homolog 7
CCDC186 coiled-coil domain containing 186
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CIR1 corepressor interacting with RBPJ, 1
COPZ2 coatomer protein complex, subunit zeta 2
CYHR1 cysteine/histidine-rich 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DBP D site of albumin promoter (albumin D-box) binding protein
DEPTOR DEP domain containing MTOR-interacting protein
DVL2 dishevelled segment polarity protein 2
EPB41L5 erythrocyte membrane protein band 4.1 like 5
FZD2 frizzled class receptor 2
GK3P glycerol kinase 3 pseudogene
GLS glutaminase
GRB7 growth factor receptor-bound protein 7
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2AG histone cluster 1, H2ag
HIST1H2AM histone cluster 1, H2am
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H2BO histone cluster 1, H2bo
HIST1H3B histone cluster 1, H3b
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2AA3 histone cluster 2, H2aa3
HIST2H2BE histone cluster 2, H2be
IRS2 insulin receptor substrate 2
KIAA0319L KIAA0319-like
KLHL24 kelch-like family member 24
LGALS8 lectin, galactoside-binding, soluble, 8
MAST2 microtubule associated serine/threonine kinase 2
MCL1 myeloid cell leukemia 1
MXD3 MAX dimerization protein 3
MXD4 MAX dimerization protein 4
NBR1 neighbor of BRCA1 gene 1
NDRG1 N-myc downstream regulated 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCM1 pericentriolar material 1
PCNX pecanex homolog (Drosophila)
PDE4DIP phosphodiesterase 4D interacting protein
PNRC1 proline-rich nuclear receptor coactivator 1
PSEN1 presenilin 1
PTCH1 patched 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPRA protein tyrosine phosphatase, receptor type, A
RALGDS ral guanine nucleotide dissociation stimulator
RIN2 Ras and Rab interactor 2
RPL35A ribosomal protein L35a
RPS3A ribosomal protein S3A
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RTN2 reticulon 2
SGSM2 small G protein signaling modulator 2
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SOS2 son of sevenless homolog 2 (Drosophila)
SPPL2B signal peptide peptidase like 2B
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
STAT2 signal transducer and activator of transcription 2, 113kDa
STK11 serine/threonine kinase 11
STON1 stonin 1
SUGP1 SURP and G patch domain containing 1
TBC1D2B TBC1 domain family, member 2B
TCAF1 TRPM8 channel-associated factor 1
TCP11L1 t-complex 11, testis-specific-like 1
TRIM66 tripartite motif containing 66
TXNIP thioredoxin interacting protein
VAC14 Vac14 homolog (S. cerevisiae)
VAMP5 vesicle-associated membrane protein 5
ZER1 zyg-11 related, cell cycle regulator
ZFP2 ZFP2 zinc finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF10 zinc finger protein 10
ZNF23 zinc finger protein 23
ZNF286A zinc finger protein 286A
ZNF33B zinc finger protein 33B
ZNF446 zinc finger protein 446
ZNF606 zinc finger protein 606

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADORA2B adenosine A2b receptor
AEN apoptosis enhancing nuclease
ATG4A autophagy related 4A, cysteine peptidase
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C1ORF106 chromosome 1 open reading frame 106
C2CD2 C2 calcium-dependent domain containing 2
CA2 carbonic anhydrase II
CCDC86 coiled-coil domain containing 86
CCNE1 cyclin E1
CENPB centromere protein B, 80kDa
CEP72 centrosomal protein 72kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CISH cytokine inducible SH2-containing protein
CLDN9 claudin 9
COA7 cytochrome c oxidase assembly factor 7 (putative)
CORO1A coronin, actin binding protein, 1A
CUTC cutC copper transporter
DENND4B DENN/MADD domain containing 4B
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
DUSP5 dual specificity phosphatase 5
DUSP8 dual specificity phosphatase 8
EFHD1 EF-hand domain family, member D1
EFHD2 EF-hand domain family, member D2
EGR3 early growth response 3
EHD3 EH-domain containing 3
ELOVL4 ELOVL fatty acid elongase 4
ERCC4 excision repair cross-complementation group 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHOD1 formin homology 2 domain containing 1
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GJA1 gap junction protein, alpha 1, 43kDa
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GRWD1 glutamate-rich WD repeat containing 1
HELLS helicase, lymphoid-specific
HPS5 Hermansky-Pudlak syndrome 5
HSPA2 heat shock 70kDa protein 2
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
IPP intracisternal A particle-promoted polypeptide
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0125 KIAA0125
LMNB2 lamin B2
MAP7D1 MAP7 domain containing 1
MCM10 minichromosome maintenance complex component 10
MED22 mediator complex subunit 22
MICALL1 MICAL-like 1
MIR22HG MIR22 host gene
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MYBBP1A MYB binding protein (P160) 1a
MYO19 myosin XIX
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NCS1 neuronal calcium sensor 1
NDRG4 NDRG family member 4
OLFML3 olfactomedin-like 3
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PAK1IP1 PAK1 interacting protein 1
PAQR4 progestin and adipoQ receptor family member IV
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PJA1 praja ring finger 1, E3 ubiquitin protein ligase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RGS19 regulator of G-protein signaling 19
RPP25 ribonuclease P/MRP 25kDa subunit
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SCAMP5 secretory carrier membrane protein 5
SCO2 SCO2 cytochrome c oxidase assembly protein
SFMBT1 Scm-like with four mbt domains 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC46A3 solute carrier family 46, member 3
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SNHG3 small nucleolar RNA host gene 3
SPAG1 sperm associated antigen 1
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SUSD4 sushi domain containing 4
SYCP2 synaptonemal complex protein 2
THEM6 thioesterase superfamily member 6
THOP1 thimet oligopeptidase 1
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)
TUBA4A tubulin, alpha 4a
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UNC119 unc-119 homolog (C. elegans)
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
ZBED1 zinc finger, BED-type containing 1
ZCCHC8 zinc finger, CCHC domain containing 8
ZXDC ZXD family zinc finger C