LM-1685-612 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the LM-1685-612 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALPK1 alpha-kinase 1
ANO10 anoctamin 10
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
B3GAT3 beta-1,3-glucuronyltransferase 3
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
BRAP BRCA1 associated protein
C16ORF59 chromosome 16 open reading frame 59
C1ORF109 chromosome 1 open reading frame 109
C22ORF29 chromosome 22 open reading frame 29
C4BPA complement component 4 binding protein, alpha
CACNG2 calcium channel, voltage-dependent, gamma subunit 2
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHN1 chimerin 1
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COBLL1 cordon-bleu WH2 repeat protein-like 1
CREM cAMP responsive element modulator
CRYAB crystallin, alpha B
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
EFNB3 ephrin-B3
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPS8L1 EPS8-like 1
FGL1 fibrinogen-like 1
GRIP2 glutamate receptor interacting protein 2
GTPBP2 GTP binding protein 2
GUCA2A guanylate cyclase activator 2A (guanylin)
HCRP1 hepatocellular carcinoma-related HCRP1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HHIPL2 HHIP-like 2
HNF4A hepatocyte nuclear factor 4, alpha
HPS1 Hermansky-Pudlak syndrome 1
IFRD1 interferon-related developmental regulator 1
IL19 interleukin 19
KIF25 kinesin family member 25
LHB luteinizing hormone beta polypeptide
LMO4 LIM domain only 4
MAP1B microtubule-associated protein 1B
MAP4 microtubule-associated protein 4
MBNL2 muscleblind-like splicing regulator 2
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MTERF4 mitochondrial transcription termination factor 4
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MVK mevalonate kinase
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NEBL nebulette
NF1 neurofibromin 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NUPR1 nuclear protein, transcriptional regulator, 1
OR5I1 olfactory receptor, family 5, subfamily I, member 1
PAIP2B poly(A) binding protein interacting protein 2B
PCGF1 polycomb group ring finger 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTBP3 polypyrimidine tract binding protein 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RNF43 ring finger protein 43
RPL10 ribosomal protein L10
SGSM2 small G protein signaling modulator 2
SIL1 SIL1 nucleotide exchange factor
SIRPA signal-regulatory protein alpha
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
STK19 serine/threonine kinase 19
TAOK2 TAO kinase 2
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TRIB3 tribbles pseudokinase 3
TRIM33 tripartite motif containing 33
VEGFA vascular endothelial growth factor A
VRK3 vaccinia related kinase 3
WDR18 WD repeat domain 18
ZCCHC11 zinc finger, CCHC domain containing 11
ZNF287 zinc finger protein 287
ZNF451 zinc finger protein 451
ZNF576 zinc finger protein 576

decreased expression

Symbol Name
ADORA3 adenosine A3 receptor
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMN amnion associated transmembrane protein
ANAPC10 anaphase promoting complex subunit 10
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARMC7 armadillo repeat containing 7
ARR3 arrestin 3, retinal (X-arrestin)
ASTE1 asteroid homolog 1 (Drosophila)
ATG14 autophagy related 14
BATF3 basic leucine zipper transcription factor, ATF-like 3
C12ORF43 chromosome 12 open reading frame 43
CA11 carbonic anhydrase XI
CALCOCO1 calcium binding and coiled-coil domain 1
CAMKV CaM kinase-like vesicle-associated
CBR3 carbonyl reductase 3
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CHMP6 charged multivesicular body protein 6
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLSTN2 calsyntenin 2
CNPY3 canopy FGF signaling regulator 3
COG7 component of oligomeric golgi complex 7
COPZ2 coatomer protein complex, subunit zeta 2
DENND1B DENN/MADD domain containing 1B
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKFZP586I1420 uncharacterized protein DKFZp586I1420
DMTN dematin actin binding protein
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EPX eosinophil peroxidase
ERCC6L excision repair cross-complementation group 6-like
ESRP2 epithelial splicing regulatory protein 2
EXOC3 exocyst complex component 3
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GMIP GEM interacting protein
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GOLM1 golgi membrane protein 1
GRIA4 glutamate receptor, ionotropic, AMPA 4
HELLS helicase, lymphoid-specific
HOXC13 homeobox C13
ITPKB inositol-trisphosphate 3-kinase B
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLF15 Kruppel-like factor 15
KLHL3 kelch-like family member 3
KLHL36 kelch-like family member 36
KLK8 kallikrein-related peptidase 8
LHX6 LIM homeobox 6
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAP6D1 MAP6 domain containing 1
MSX1 msh homeobox 1
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NAT6 N-acetyltransferase 6 (GCN5-related)
NBEA neurobeachin
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NRGN neurogranin (protein kinase C substrate, RC3)
OCEL1 occludin/ELL domain containing 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PDZD7 PDZ domain containing 7
PGP phosphoglycolate phosphatase
PHC1 polyhomeotic homolog 1 (Drosophila)
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRKCD protein kinase C, delta
PRPF3 pre-mRNA processing factor 3
PTPN3 protein tyrosine phosphatase, non-receptor type 3
RAMP3 receptor (G protein-coupled) activity modifying protein 3
RBM14 RNA binding motif protein 14
RBM41 RNA binding motif protein 41
RING1 ring finger protein 1
RPIA ribose 5-phosphate isomerase A
RPUSD2 RNA pseudouridylate synthase domain containing 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SNX6 sorting nexin 6
SPON2 spondin 2, extracellular matrix protein
STX1A syntaxin 1A (brain)
SUSD4 sushi domain containing 4
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TBL3 transducin (beta)-like 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCTN1 tectonic family member 1
TGM3 transglutaminase 3
TGM5 transglutaminase 5
TMCC2 transmembrane and coiled-coil domain family 2
TMEM115 transmembrane protein 115
TNS3 tensin 3
VIM vimentin
WDR13 WD repeat domain 13
ZBED1 zinc finger, BED-type containing 1
ZBTB22 zinc finger and BTB domain containing 22
ZCCHC6 zinc finger, CCHC domain containing 6
ZNF394 zinc finger protein 394
ZNF428 zinc finger protein 428