LEFTY2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description left-right determination factor 2|This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2010] (NCBI Entrez Gene Database, 7044)
External Link http://www.ncbi.nlm.nih.gov/gene/7044
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Genes

29 interacting proteins for LEFTY2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACSS3 acyl-CoA synthetase short-chain family member 3
ACTL6A actin-like 6A
ACVR1B activin A receptor, type IB
ACVR1C activin A receptor, type IC
ACVR2A activin A receptor, type IIA
ACVR2B activin A receptor, type IIB
ARID1A AT rich interactive domain 1A (SWI-like)
ARID1B AT rich interactive domain 1B (SWI1-like)
BAMBI BMP and activin membrane-bound inhibitor
CFC1 cripto, FRL-1, cryptic family 1
FKBP1A FK506 binding protein 1A, 12kDa
GDF1 growth differentiation factor 1
HRAS Harvey rat sarcoma viral oncogene homolog
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP3K7CL MAP3K7 C-terminal like
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
NODAL nodal growth differentiation factor
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
RRAS related RAS viral (r-ras) oncogene homolog
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD9 SMAD family member 9
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
TDGF1 teratocarcinoma-derived growth factor 1