LCLC-103H Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
Description disease: carcinoma, large cell (Cell Line Ontology, CLO_0007282)
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Genes

356 genes with high or low expression in LCLC-103H relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
FBXO22 F-box protein 22 3.27667
TRIO trio Rho guanine nucleotide exchange factor 3.07417
WDR45 WD repeat domain 45 2.74591
RANGAP1 Ran GTPase activating protein 1 2.48493
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 2.42935
KCTD5 potassium channel tetramerization domain containing 5 2.38898
ABLIM3 actin binding LIM protein family, member 3 2.35232
EIF6 eukaryotic translation initiation factor 6 2.29562
FKBP15 FK506 binding protein 15, 133kDa 2.28708
VAC14 Vac14 homolog (S. cerevisiae) 2.25872
VARS valyl-tRNA synthetase 2.21731
PEX6 peroxisomal biogenesis factor 6 2.16503
SPANXC SPANX family, member C 2.15716
CNN1 calponin 1, basic, smooth muscle 2.13162
DMRT1 doublesex and mab-3 related transcription factor 1 2.13059
MRPS16 mitochondrial ribosomal protein S16 2.07589
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit 1.98998
OPTN optineurin 1.98916
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 1.97134
NELFE negative elongation factor complex member E 1.96143
DYSF dysferlin 1.94904
CRLF2 cytokine receptor-like factor 2 1.93017
NMT2 N-myristoyltransferase 2 1.91732
MAGEB2 melanoma antigen family B2 1.90024
STX4 syntaxin 4 1.87651
CDA cytidine deaminase 1.87488
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 1.86156
TFE3 transcription factor binding to IGHM enhancer 3 1.85693
NXF2 nuclear RNA export factor 2 1.84977
RIC8A RIC8 guanine nucleotide exchange factor A 1.84639
CDCP1 CUB domain containing protein 1 1.83286
RCL1 RNA terminal phosphate cyclase-like 1 1.80719
CTAG2 cancer/testis antigen 2 1.79835
CAMTA2 calmodulin binding transcription activator 2 1.78043
GPN1 GPN-loop GTPase 1 1.77422
RRAGA Ras-related GTP binding A 1.77264
TLN1 talin 1 1.76213
MRPS10 mitochondrial ribosomal protein S10 1.76167
TARS threonyl-tRNA synthetase 1.76039
ECD ecdysoneless homolog (Drosophila) 1.75517
ICE1 interactor of little elongation complex ELL subunit 1 1.7451
KIAA0020 KIAA0020 1.73758
LHFPL2 lipoma HMGIC fusion partner-like 2 1.73695
CYLD cylindromatosis (turban tumor syndrome) 1.73662
PSG9 pregnancy specific beta-1-glycoprotein 9 1.73307
BRD9 bromodomain containing 9 1.73235
WDR46 WD repeat domain 46 1.72708
GTPBP2 GTP binding protein 2 1.7259
CTH cystathionine gamma-lyase 1.71203
KIFC3 kinesin family member C3 1.70838
AATF apoptosis antagonizing transcription factor 1.70311
NDRG4 NDRG family member 4 1.69968
EXOC3 exocyst complex component 3 1.69345
NUDC nudC nuclear distribution protein 1.68528
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 1.67281
ZPR1 ZPR1 zinc finger 1.66918
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 1.66774
FAM65A family with sequence similarity 65, member A 1.66401
NPPB natriuretic peptide B 1.66236
CDC37L1 cell division cycle 37-like 1 1.6623
PAPPA2 pappalysin 2 1.65699
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.64732
GFPT2 glutamine-fructose-6-phosphate transaminase 2 1.63871
DOCK9 dedicator of cytokinesis 9 1.62938
REPS2 RALBP1 associated Eps domain containing 2 1.62864
DROSHA drosha, ribonuclease type III 1.61468
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 1.59138
MAGEA11 melanoma antigen family A11 1.58583
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 1.583
PLIN2 perilipin 2 1.57786
BMS1 BMS1 ribosome biogenesis factor 1.57576
EDC3 enhancer of mRNA decapping 3 1.57206
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 1.57194
CCDC22 coiled-coil domain containing 22 1.56758
DAXX death-domain associated protein 1.56252
MRPS18B mitochondrial ribosomal protein S18B 1.56085
RRAD Ras-related associated with diabetes 1.55177
RING1 ring finger protein 1 1.54815
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) 1.54614
TMEM14B transmembrane protein 14B 1.53992
EPHB2 EPH receptor B2 1.53769
MOCS1 molybdenum cofactor synthesis 1 1.53251
CEP250 centrosomal protein 250kDa 1.53136
SAR1B secretion associated, Ras related GTPase 1B 1.52829
ADAM12 ADAM metallopeptidase domain 12 1.5263
NRBP1 nuclear receptor binding protein 1 1.51516
UPP1 uridine phosphorylase 1 1.51267
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 1.51163
FOSL1 FOS-like antigen 1 1.50515
MRPS18A mitochondrial ribosomal protein S18A 1.5036
RPL23AP7 ribosomal protein L23a pseudogene 7 1.49841
PRDM4 PR domain containing 4 1.4982
WDR70 WD repeat domain 70 1.49773
PFDN6 prefoldin subunit 6 1.49698
HARS2 histidyl-tRNA synthetase 2, mitochondrial 1.49581
OLAH oleoyl-ACP hydrolase 1.49473
SCAND1 SCAN domain containing 1 1.49238
NME7 NME/NM23 family member 7 1.49136
LRRC61 leucine rich repeat containing 61 1.4855
GTF2IRD1 GTF2I repeat domain containing 1 1.48371
UBE2Z ubiquitin-conjugating enzyme E2Z 1.47796
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 1.47412
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) 1.46597
RUSC2 RUN and SH3 domain containing 2 1.44695
MRPL28 mitochondrial ribosomal protein L28 1.43947
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 1.43803
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial 1.43202
PSG6 pregnancy specific beta-1-glycoprotein 6 1.41873
LRRC8E leucine rich repeat containing 8 family, member E 1.41807
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 1.41681

low expression

Symbol Name Standardized Value
RBX1 ring-box 1, E3 ubiquitin protein ligase -3.33588
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 -3.09534
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like -3.05021
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -3.01501
SCYL3 SCY1-like 3 (S. cerevisiae) -2.96084
PROL1 proline rich, lacrimal 1 -2.95155
STRN striatin, calmodulin binding protein -2.8739
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 -2.867
IFT74 intraflagellar transport 74 -2.81819
ATXN10 ataxin 10 -2.69483
CIZ1 CDKN1A interacting zinc finger protein 1 -2.62039
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 -2.58493
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 -2.5753
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -2.55351
LATS1 large tumor suppressor kinase 1 -2.53405
TAS2R14 taste receptor, type 2, member 14 -2.52345
TSPYL5 TSPY-like 5 -2.5144
GGT5 gamma-glutamyltransferase 5 -2.43477
CST1 cystatin SN -2.42855
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -2.4268
CARD9 caspase recruitment domain family, member 9 -2.42537
SLC22A17 solute carrier family 22, member 17 -2.42029
PCDHGC3 protocadherin gamma subfamily C, 3 -2.41633
KANK3 KN motif and ankyrin repeat domains 3 -2.40761
ART3 ADP-ribosyltransferase 3 -2.40589
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 -2.38452
ADH6 alcohol dehydrogenase 6 (class V) -2.38069
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) -2.33075
H3F3A H3 histone, family 3A -2.32261
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 -2.30757
NHLH2 nescient helix loop helix 2 -2.29649
DRP2 dystrophin related protein 2 -2.26193
MSTN myostatin -2.25008
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 -2.24131
CLDN18 claudin 18 -2.225
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -2.22408
FOXE1 forkhead box E1 -2.21056
SAP18 Sin3A-associated protein, 18kDa -2.19169
HIC1 hypermethylated in cancer 1 -2.18305
HIST1H4A histone cluster 1, H4a -2.16285
TULP2 tubby like protein 2 -2.15742
NELFCD negative elongation factor complex member C/D -2.14968
GP2 glycoprotein 2 (zymogen granule membrane) -2.14668
SH2D3C SH2 domain containing 3C -2.143
NUP50 nucleoporin 50kDa -2.12363
DRD3 dopamine receptor D3 -2.11193
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 -2.10829
LHCGR luteinizing hormone/choriogonadotropin receptor -2.08391
ZNF10 zinc finger protein 10 -2.07576
RPE65 retinal pigment epithelium-specific protein 65kDa -2.0751
SEMG1 semenogelin I -2.05121
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) -2.03089
HPD 4-hydroxyphenylpyruvate dioxygenase -2.02589
NRXN2 neurexin 2 -2.02575
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 -2.02206
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa -2.01331
TMPRSS11D transmembrane protease, serine 11D -2.01328
PRDM10 PR domain containing 10 -2.01065
OXT oxytocin/neurophysin I prepropeptide -2.01026
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha -2.00974
HOXA11 homeobox A11 -2.00957
TIA1 TIA1 cytotoxic granule-associated RNA binding protein -1.98882
FSHB follicle stimulating hormone, beta polypeptide -1.98864
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 -1.985
GAB1 GRB2-associated binding protein 1 -1.98376
THAP7 THAP domain containing 7 -1.97362
VIPR2 vasoactive intestinal peptide receptor 2 -1.97055
GIMAP5 GTPase, IMAP family member 5 -1.95611
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -1.94109
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) -1.93313
KLHL22 kelch-like family member 22 -1.92191
CLSTN2 calsyntenin 2 -1.91975
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2 -1.91733
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -1.91047
ZNF135 zinc finger protein 135 -1.90513
GPR18 G protein-coupled receptor 18 -1.90278
GCM1 glial cells missing homolog 1 (Drosophila) -1.89501
CKM creatine kinase, muscle -1.88916
GLP2R glucagon-like peptide 2 receptor -1.88616
CDHR2 cadherin-related family member 2 -1.88441
ADAM3A ADAM metallopeptidase domain 3A (pseudogene) -1.87701
BMP10 bone morphogenetic protein 10 -1.8737
PTTG2 pituitary tumor-transforming 2 -1.86923
GIF gastric intrinsic factor (vitamin B synthesis) -1.86856
CYSLTR2 cysteinyl leukotriene receptor 2 -1.86849
GFI1B growth factor independent 1B transcription repressor -1.86517
SNRPN small nuclear ribonucleoprotein polypeptide N -1.86094
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -1.85798
CTSG cathepsin G -1.85327
EIF4A2 eukaryotic translation initiation factor 4A2 -1.84452
EFNA3 ephrin-A3 -1.82902
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -1.82695
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2 -1.81789
CXCR6 chemokine (C-X-C motif) receptor 6 -1.81294
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) -1.81183
FAM83E family with sequence similarity 83, member E -1.81178
RIC3 RIC3 acetylcholine receptor chaperone -1.81019
POU3F3 POU class 3 homeobox 3 -1.80743
PITPNB phosphatidylinositol transfer protein, beta -1.80628
PSPC1 paraspeckle component 1 -1.80582
CREBZF CREB/ATF bZIP transcription factor -1.80254
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A -1.80164
PCF11 PCF11 cleavage and polyadenylation factor subunit -1.79147
SCAF4 SR-related CTD-associated factor 4 -1.79135
KIR2DS2 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2 -1.78441
FN3K fructosamine 3 kinase -1.78157
CCDC130 coiled-coil domain containing 130 -1.77961
IVNS1ABP influenza virus NS1A binding protein -1.77897
PDS5B PDS5 cohesin associated factor B -1.77572
CDX2 caudal type homeobox 2 -1.77349
NDUFA4 NDUFA4, mitochondrial complex associated -1.77181
MAPK10 mitogen-activated protein kinase 10 -1.77036
FLJ11710 uncharacterized protein FLJ11710 -1.76048
GPR88 G protein-coupled receptor 88 -1.7546
CNKSR2 connector enhancer of kinase suppressor of Ras 2 -1.75446
TUBB1 tubulin, beta 1 class VI -1.75153
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker) -1.74962
SYN3 synapsin III -1.74569
HIC2 hypermethylated in cancer 2 -1.74281
CD27 CD27 molecule -1.74213
NPHP1 nephronophthisis 1 (juvenile) -1.73742
ATOH1 atonal homolog 1 (Drosophila) -1.73632
TNRC6B trinucleotide repeat containing 6B -1.72977
FAAH fatty acid amide hydrolase -1.7245
IL1RL2 interleukin 1 receptor-like 2 -1.72198
CHGA chromogranin A -1.71934
VSX1 visual system homeobox 1 -1.7141
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -1.71167
BMP8A bone morphogenetic protein 8a -1.71157
GPR173 G protein-coupled receptor 173 -1.70671
DBP D site of albumin promoter (albumin D-box) binding protein -1.69834
PPA2 pyrophosphatase (inorganic) 2 -1.69211
TAS2R3 taste receptor, type 2, member 3 -1.69086
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 -1.68585
UTF1 undifferentiated embryonic cell transcription factor 1 -1.67523
PTH2R parathyroid hormone 2 receptor -1.67292
AKR1C4 aldo-keto reductase family 1, member C4 -1.6703
HOXA4 homeobox A4 -1.66817
ANGEL1 angel homolog 1 (Drosophila) -1.6675
DLX5 distal-less homeobox 5 -1.66595
SF3B1 splicing factor 3b, subunit 1, 155kDa -1.66011
EI24 etoposide induced 2.4 -1.6521
DGKQ diacylglycerol kinase, theta 110kDa -1.65021
NKX6-1 NK6 homeobox 1 -1.64844
THRB thyroid hormone receptor, beta -1.64431
PNN pinin, desmosome associated protein -1.64406
RPS28 ribosomal protein S28 -1.64251
LRRTM2 leucine rich repeat transmembrane neuronal 2 -1.64128
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2 -1.63991
ADAM20 ADAM metallopeptidase domain 20 -1.63969
SSTR1 somatostatin receptor 1 -1.63764
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) -1.6334
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 -1.62805
ALAS2 5'-aminolevulinate synthase 2 -1.61349
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit -1.61339
RANBP1 RAN binding protein 1 -1.61029
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 -1.60596
NTN1 netrin 1 -1.60368
IRGC immunity-related GTPase family, cinema -1.60338
TRGV7 T cell receptor gamma variable 7 (pseudogene) -1.60091
KRT33B keratin 33B, type I -1.59989
FRAS1 Fraser extracellular matrix complex subunit 1 -1.59935
PUM2 pumilio RNA-binding family member 2 -1.59549
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 -1.5921
KLK10 kallikrein-related peptidase 10 -1.58881
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 -1.57741
FNDC3A fibronectin type III domain containing 3A -1.57288
RGS6 regulator of G-protein signaling 6 -1.57197
KLF15 Kruppel-like factor 15 -1.56749
HPX hemopexin -1.56683
EPS15P1 epidermal growth factor receptor pathway substrate 15 pseudogene 1 -1.5651
DEFA5 defensin, alpha 5, Paneth cell-specific -1.56064
OR7A10 olfactory receptor, family 7, subfamily A, member 10 -1.55975
HTN1 histatin 1 -1.55859
NCAPD3 non-SMC condensin II complex, subunit D3 -1.55694
S100A7 S100 calcium binding protein A7 -1.55679
BHMT2 betaine--homocysteine S-methyltransferase 2 -1.55625
FNTB farnesyltransferase, CAAX box, beta -1.55415
LMBRD1 LMBR1 domain containing 1 -1.55013
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1 -1.54913
CLEC4A C-type lectin domain family 4, member A -1.54782
CD160 CD160 molecule -1.5477
GCLC glutamate-cysteine ligase, catalytic subunit -1.54732
HMGXB4 HMG box domain containing 4 -1.54618
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 -1.54242
CXXC4 CXXC finger protein 4 -1.54026
CAPN3 calpain 3, (p94) -1.53686
TLR1 toll-like receptor 1 -1.53637
FHL5 four and a half LIM domains 5 -1.53458
PLEKHH3 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 -1.52218
LCE2B late cornified envelope 2B -1.51459
MEFV Mediterranean fever -1.51163
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 -1.51161
KCNK7 potassium channel, two pore domain subfamily K, member 7 -1.51033
CDH20 cadherin 20, type 2 -1.50974
CCT8L2 chaperonin containing TCP1, subunit 8 (theta)-like 2 -1.50523
GUCY2D guanylate cyclase 2D, membrane (retina-specific) -1.50332
EPHX3 epoxide hydrolase 3 -1.50315
DCLK2 doublecortin-like kinase 2 -1.50158
RAB11B RAB11B, member RAS oncogene family -1.4993
MAGEF1 melanoma antigen family F1 -1.49801
PSORS1C2 psoriasis susceptibility 1 candidate 2 -1.49573
IL18RAP interleukin 18 receptor accessory protein -1.49517
SEMG2 semenogelin II -1.49439
TNNI1 troponin I type 1 (skeletal, slow) -1.49423
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 -1.49248
RBM4 RNA binding motif protein 4 -1.49226
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) -1.49144
ZNF143 zinc finger protein 143 -1.4914
FGFBP1 fibroblast growth factor binding protein 1 -1.48881
GNRH2 gonadotropin-releasing hormone 2 -1.48674
SUGP1 SURP and G patch domain containing 1 -1.48673
GPR32 G protein-coupled receptor 32 -1.48584
KRT3 keratin 3, type II -1.48329
RAB3A RAB3A, member RAS oncogene family -1.47933
CA7 carbonic anhydrase VII -1.47675
CLC Charcot-Leyden crystal galectin -1.47557
CAMK1G calcium/calmodulin-dependent protein kinase IG -1.47451
CFP complement factor properdin -1.47413
FOXD3 forkhead box D3 -1.46932
POU2AF1 POU class 2 associating factor 1 -1.46686
PLN phospholamban -1.46604
MYL2 myosin, light chain 2, regulatory, cardiac, slow -1.46334
FBLN2 fibulin 2 -1.46093
ADRA2A adrenoceptor alpha 2A -1.45608
ZNF471 zinc finger protein 471 -1.45553
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like -1.45499
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -1.45362
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide -1.45104
ERCC5 excision repair cross-complementation group 5 -1.45087
MRPL57 mitochondrial ribosomal protein L57 -1.44744
G6PC glucose-6-phosphatase, catalytic subunit -1.44634
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 -1.44334
RPS11 ribosomal protein S11 -1.44262
CYBB cytochrome b-245, beta polypeptide -1.44102
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -1.44099
KLK8 kallikrein-related peptidase 8 -1.4392
PLXDC1 plexin domain containing 1 -1.43742
SENP7 SUMO1/sentrin specific peptidase 7 -1.43583
RBP4 retinol binding protein 4, plasma -1.43403
GPR87 G protein-coupled receptor 87 -1.42886
GRIP1 glutamate receptor interacting protein 1 -1.4275
GP9 glycoprotein IX (platelet) -1.42519
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 -1.42503
DNAH9 dynein, axonemal, heavy chain 9 -1.41953
NPPA natriuretic peptide A -1.41929