L-methionine sulfoximine-4151 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the L-methionine sulfoximine-4151 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
ALK anaplastic lymphoma receptor tyrosine kinase
AQP3 aquaporin 3 (Gill blood group)
ATF7IP activating transcription factor 7 interacting protein
ATP10B ATPase, class V, type 10B
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BHMT2 betaine--homocysteine S-methyltransferase 2
BLK BLK proto-oncogene, Src family tyrosine kinase
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BTNL2 butyrophilin-like 2
C11ORF16 chromosome 11 open reading frame 16
C1ORF95 chromosome 1 open reading frame 95
C4ORF29 chromosome 4 open reading frame 29
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CALB1 calbindin 1, 28kDa
CALB2 calbindin 2
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CFDP1 craniofacial development protein 1
CFLAR CASP8 and FADD-like apoptosis regulator
CLGN calmegin
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CTBP2 C-terminal binding protein 2
CTIF CBP80/20-dependent translation initiation factor
CXCR6 chemokine (C-X-C motif) receptor 6
DNALI1 dynein, axonemal, light intermediate chain 1
DPF1 D4, zinc and double PHD fingers family 1
DTX2 deltex 2, E3 ubiquitin ligase
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDA ectodysplasin A
EDN1 endothelin 1
EGR2 early growth response 2
FLT3 fms-related tyrosine kinase 3
FRS3 fibroblast growth factor receptor substrate 3
FZD5 frizzled class receptor 5
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GOLGA4 golgin A4
GRM8 glutamate receptor, metabotropic 8
GUSBP3 glucuronidase, beta pseudogene 3
GYPB glycophorin B (MNS blood group)
HES2 hes family bHLH transcription factor 2
HOXB5 homeobox B5
ICOSLG inducible T-cell co-stimulator ligand
IGL immunoglobulin lambda locus
KALRN kalirin, RhoGEF kinase
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MALL mal, T-cell differentiation protein-like
MAPK7 mitogen-activated protein kinase 7
MBD2 methyl-CpG binding domain protein 2
MED18 mediator complex subunit 18
METTL7A methyltransferase like 7A
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MMP13 matrix metallopeptidase 13
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MT3 metallothionein 3
NACA2 nascent polypeptide-associated complex alpha subunit 2
NCR1 natural cytotoxicity triggering receptor 1
NUP88 nucleoporin 88kDa
OR10H3 olfactory receptor, family 10, subfamily H, member 3
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PCDHB12 protocadherin beta 12
PCOLCE procollagen C-endopeptidase enhancer
POFUT1 protein O-fucosyltransferase 1
POU3F2 POU class 3 homeobox 2
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PTCRA pre T-cell antigen receptor alpha
R3HDM1 R3H domain containing 1
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RGS12 regulator of G-protein signaling 12
RGS4 regulator of G-protein signaling 4
RNGTT RNA guanylyltransferase and 5'-phosphatase
RUNX1 runt-related transcription factor 1
SAYSD1 SAYSVFN motif domain containing 1
SBNO1 strawberry notch homolog 1 (Drosophila)
SECTM1 secreted and transmembrane 1
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC12A8 solute carrier family 12, member 8
SLC35G2 solute carrier family 35, member G2
SNX29 sorting nexin 29
SOX21 SRY (sex determining region Y)-box 21
SP140L SP140 nuclear body protein-like
SPEG SPEG complex locus
STAC SH3 and cysteine rich domain
SYT2 synaptotagmin II
TAOK2 TAO kinase 2
TDRD12 tudor domain containing 12
TEP1 telomerase-associated protein 1
TMEM63A transmembrane protein 63A
TNS1 tensin 1
TPP1 tripeptidyl peptidase I
USP22 ubiquitin specific peptidase 22
YY2 YY2 transcription factor
ZNF652 zinc finger protein 652

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ACTL8 actin-like 8
AMPD1 adenosine monophosphate deaminase 1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARC activity-regulated cytoskeleton-associated protein
ARHGAP4 Rho GTPase activating protein 4
ASIC3 acid sensing (proton gated) ion channel 3
BARX2 BARX homeobox 2
BCL2A1 BCL2-related protein A1
C11ORF21 chromosome 11 open reading frame 21
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCDC71 coiled-coil domain containing 71
CDH18 cadherin 18, type 2
CDHR2 cadherin-related family member 2
CHML choroideremia-like (Rab escort protein 2)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLDN1 claudin 1
CLEC4E C-type lectin domain family 4, member E
CNGB3 cyclic nucleotide gated channel beta 3
CNTFR ciliary neurotrophic factor receptor
CPB2 carboxypeptidase B2 (plasma)
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DCBLD2 discoidin, CUB and LCCL domain containing 2
DLK2 delta-like 2 homolog (Drosophila)
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DSPP dentin sialophosphoprotein
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM155A family with sequence similarity 155, member A
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FRAS1 Fraser extracellular matrix complex subunit 1
FSCN3 fascin actin-bundling protein 3, testicular
GBP2 guanylate binding protein 2, interferon-inducible
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPRC5D G protein-coupled receptor, class C, group 5, member D
GSTTP1 glutathione S-transferase theta pseudogene 1
HAMP hepcidin antimicrobial peptide
HCAR3 hydroxycarboxylic acid receptor 3
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIST1H1E histone cluster 1, H1e
HMOX1 heme oxygenase 1
HPX hemopexin
HSPB6 heat shock protein, alpha-crystallin-related, B6
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNIP1 Kv channel interacting protein 1
KEL Kell blood group, metallo-endopeptidase
LEFTY1 left-right determination factor 1
LHX1 LIM homeobox 1
LHX3 LIM homeobox 3
LY86 lymphocyte antigen 86
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MOB3B MOB kinase activator 3B
MX1 MX dynamin-like GTPase 1
NPTX1 neuronal pentraxin I
NPY4R neuropeptide Y receptor Y4
OCA2 oculocutaneous albinism II
ONECUT1 one cut homeobox 1
ONECUT2 one cut homeobox 2
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PADI1 peptidyl arginine deiminase, type I
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLSCR4 phospholipid scramblase 4
POLH polymerase (DNA directed), eta
POPDC3 popeye domain containing 3
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PTPRM protein tyrosine phosphatase, receptor type, M
REM1 RAS (RAD and GEM)-like GTP-binding 1
RFXAP regulatory factor X-associated protein
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RORC RAR-related orphan receptor C
RPS4Y1 ribosomal protein S4, Y-linked 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SDC3 syndecan 3
SEPP1 selenoprotein P, plasma, 1
SIGLEC15 sialic acid binding Ig-like lectin 15
SIX1 SIX homeobox 1
SPAG4 sperm associated antigen 4
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPTA1 spectrin, alpha, erythrocytic 1
STARD3 StAR-related lipid transfer (START) domain containing 3
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAOK1 TAO kinase 1
TAS2R4 taste receptor, type 2, member 4
TEX14 testis expressed 14
TFF2 trefoil factor 2
THAP9 THAP domain containing 9
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TTC30A tetratricopeptide repeat domain 30A
TTC4 tetratricopeptide repeat domain 4
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WNT10B wingless-type MMTV integration site family, member 10B
ZNF197 zinc finger protein 197
ZNF230 zinc finger protein 230
ZNF484 zinc finger protein 484