L-methionine sulfoximine-4070 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the L-methionine sulfoximine-4070 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ADAM29 ADAM metallopeptidase domain 29
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ALDOB aldolase B, fructose-bisphosphate
APP amyloid beta (A4) precursor protein
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BCL6 B-cell CLL/lymphoma 6
BLZF1 basic leucine zipper nuclear factor 1
BMP4 bone morphogenetic protein 4
BMP7 bone morphogenetic protein 7
C8ORF44 chromosome 8 open reading frame 44
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CALD1 caldesmon 1
CCR1 chemokine (C-C motif) receptor 1
CDC14A cell division cycle 14A
CDRT1 CMT1A duplicated region transcript 1
CEMP1 cementum protein 1
CEP295 centrosomal protein 295kDa
COL21A1 collagen, type XXI, alpha 1
COL3A1 collagen, type III, alpha 1
COMMD4 COMM domain containing 4
CSF1R colony stimulating factor 1 receptor
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
ESRRG estrogen-related receptor gamma
F2RL2 coagulation factor II (thrombin) receptor-like 2
FAM214B family with sequence similarity 214, member B
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GAST gastrin
GRIP2 glutamate receptor interacting protein 2
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
ICOSLG inducible T-cell co-stimulator ligand
IGF1R insulin-like growth factor 1 receptor
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL1RN interleukin 1 receptor antagonist
IL36A interleukin 36, alpha
IL36G interleukin 36, gamma
INE1 inactivation escape 1 (non-protein coding)
KIF13A kinesin family member 13A
KRT4 keratin 4, type II
LARP4B La ribonucleoprotein domain family, member 4B
LIMD2 LIM domain containing 2
LMX1B LIM homeobox transcription factor 1, beta
LOC100294391 uncharacterized LOC100294391
MAGEA5 melanoma antigen family A5
MAGEB2 melanoma antigen family B2
MAPK11 mitogen-activated protein kinase 11
MARK2 MAP/microtubule affinity-regulating kinase 2
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MTRF1L mitochondrial translational release factor 1-like
MVB12B multivesicular body subunit 12B
NF1 neurofibromin 1
NPC1 Niemann-Pick disease, type C1
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP54 nucleoporin 54kDa
OMG oligodendrocyte myelin glycoprotein
PBX2 pre-B-cell leukemia homeobox 2
PHF3 PHD finger protein 3
PKD2L2 polycystic kidney disease 2-like 2
PLA2G10 phospholipase A2, group X
PON1 paraoxonase 1
PPARD peroxisome proliferator-activated receptor delta
PPP1R37 protein phosphatase 1, regulatory subunit 37
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PRSS8 protease, serine, 8
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
REPS1 RALBP1 associated Eps domain containing 1
RHBDD3 rhomboid domain containing 3
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SCN2B sodium channel, voltage gated, type II beta subunit
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SMOX spermine oxidase
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOCS7 suppressor of cytokine signaling 7
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
STMN3 stathmin-like 3
STOML1 stomatin (EPB72)-like 1
SUGP1 SURP and G patch domain containing 1
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TBX1 T-box 1
TESPA1 thymocyte expressed, positive selection associated 1
TEX15 testis expressed 15
TFCP2L1 transcription factor CP2-like 1
TMEM206 transmembrane protein 206
TRIM29 tripartite motif containing 29
UCN urocortin
VAC14 Vac14 homolog (S. cerevisiae)
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
WNT16 wingless-type MMTV integration site family, member 16
ZNF287 zinc finger protein 287
ZNF516 zinc finger protein 516

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACBD4 acyl-CoA binding domain containing 4
ALB albumin
ANP32A-IT1 ANP32A intronic transcript 1
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
C3AR1 complement component 3a receptor 1
CDKL3 cyclin-dependent kinase-like 3
CIDEC cell death-inducing DFFA-like effector c
CINP cyclin-dependent kinase 2 interacting protein
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CPNE7 copine VII
CRMP1 collapsin response mediator protein 1
CXORF21 chromosome X open reading frame 21
DBF4B DBF4 zinc finger B
DDN dendrin
DMTN dematin actin binding protein
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DSPP dentin sialophosphoprotein
EAF2 ELL associated factor 2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EXD3 exonuclease 3'-5' domain containing 3
FKBP5 FK506 binding protein 5
GAREM GRB2 associated, regulator of MAPK1
GAS8 growth arrest-specific 8
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLS2 glutaminase 2 (liver, mitochondrial)
GMPR guanosine monophosphate reductase
GRM4 glutamate receptor, metabotropic 4
HIST1H2AI histone cluster 1, H2ai
HIST1H3A histone cluster 1, H3a
HOXA6 homeobox A6
HOXB9 homeobox B9
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
IFT140 intraflagellar transport 140
IKZF5 IKAROS family zinc finger 5 (Pegasus)
ITFG2 integrin alpha FG-GAP repeat containing 2
KDM5C lysine (K)-specific demethylase 5C
KIAA1456 KIAA1456
KIFC1 kinesin family member C1
LIME1 Lck interacting transmembrane adaptor 1
LOC100127972 uncharacterized LOC100127972
LRRC2 leucine rich repeat containing 2
MCOLN3 mucolipin 3
MDFI MyoD family inhibitor
MFGE8 milk fat globule-EGF factor 8 protein
MICALL2 MICAL-like 2
MTCP1 mature T-cell proliferation 1
MTSS1L metastasis suppressor 1-like
NAG18 NAG18 mRNA
NNAT neuronatin
NOTCH1 notch 1
NPVF neuropeptide VF precursor
NT5M 5',3'-nucleotidase, mitochondrial
NTSR1 neurotensin receptor 1 (high affinity)
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OSBP2 oxysterol binding protein 2
OXCT2 3-oxoacid CoA transferase 2
PAIP2B poly(A) binding protein interacting protein 2B
PCDH12 protocadherin 12
PGPEP1 pyroglutamyl-peptidase I
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRR4 proline rich 4 (lacrimal)
RAB33B RAB33B, member RAS oncogene family
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
REM1 RAS (RAD and GEM)-like GTP-binding 1
RPL10L ribosomal protein L10-like
S1PR1 sphingosine-1-phosphate receptor 1
SCN1B sodium channel, voltage gated, type I beta subunit
SLC16A6 solute carrier family 16, member 6
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SMA4 glucuronidase, beta pseudogene
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SSTR4 somatostatin receptor 4
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TFDP3 transcription factor Dp family, member 3
THRB thyroid hormone receptor, beta
THSD4 thrombospondin, type I, domain containing 4
TMEM212 transmembrane protein 212
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSPAN2 tetraspanin 2
TUBA3C tubulin, alpha 3c
WDR41 WD repeat domain 41
ZNF205 zinc finger protein 205
ZNF222 zinc finger protein 222
ZNF268 zinc finger protein 268
ZNF428 zinc finger protein 428
ZNF510 zinc finger protein 510
ZNF549 zinc finger protein 549
ZNF667 zinc finger protein 667
ZNF675 zinc finger protein 675
ZNF76 zinc finger protein 76
ZNF85 zinc finger protein 85
ZSCAN2 zinc finger and SCAN domain containing 2