L-methionine sulfoximine-2831 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the L-methionine sulfoximine-2831 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTL8 actin-like 8
AKAP11 A kinase (PRKA) anchor protein 11
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALPK1 alpha-kinase 1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATM ATM serine/threonine kinase
BAIAP2 BAI1-associated protein 2
C4ORF29 chromosome 4 open reading frame 29
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CASP2 caspase 2, apoptosis-related cysteine peptidase
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CFLAR CASP8 and FADD-like apoptosis regulator
CLSTN2 calsyntenin 2
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DAAM2 dishevelled associated activator of morphogenesis 2
DGCR8 DGCR8 microprocessor complex subunit
DYM dymeclin
EFHD2 EF-hand domain family, member D2
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2
EMID1 EMI domain containing 1
FLJ11710 uncharacterized protein FLJ11710
GINS4 GINS complex subunit 4 (Sld5 homolog)
GJA4 gap junction protein, alpha 4, 37kDa
GK glycerol kinase
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HDAC7 histone deacetylase 7
HFE hemochromatosis
HIC2 hypermethylated in cancer 2
HOXC10 homeobox C10
HSPB11 heat shock protein family B (small), member 11
IL6ST interleukin 6 signal transducer
JUN jun proto-oncogene
KCTD7 potassium channel tetramerization domain containing 7
KIAA1654 KIAA1654 protein
KLK8 kallikrein-related peptidase 8
LMO4 LIM domain only 4
LOC157562 uncharacterized LOC157562
LRRC37A3 leucine rich repeat containing 37, member A3
LRRC40 leucine rich repeat containing 40
MAOB monoamine oxidase B
MAP2K5 mitogen-activated protein kinase kinase 5
MAP2K7 mitogen-activated protein kinase kinase 7
MCC mutated in colorectal cancers
MED18 mediator complex subunit 18
MR1 major histocompatibility complex, class I-related
MYL10 myosin, light chain 10, regulatory
MYO1B myosin IB
NAT6 N-acetyltransferase 6 (GCN5-related)
NBL1 neuroblastoma 1, DAN family BMP antagonist
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NR4A1 nuclear receptor subfamily 4, group A, member 1
OVGP1 oviductal glycoprotein 1, 120kDa
PCDHB12 protocadherin beta 12
PGR progesterone receptor
PHF3 PHD finger protein 3
PIDD1 p53-induced death domain protein 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PQBP1 polyglutamine binding protein 1
RABGAP1 RAB GTPase activating protein 1
RBBP9 retinoblastoma binding protein 9
RBM3 RNA binding motif (RNP1, RRM) protein 3
RBPMS RNA binding protein with multiple splicing
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNFT1 ring finger protein, transmembrane 1
SBNO1 strawberry notch homolog 1 (Drosophila)
SCARA3 scavenger receptor class A, member 3
SFTPB surfactant protein B
SH3BP2 SH3-domain binding protein 2
SHANK1 SH3 and multiple ankyrin repeat domains 1
SKAP1 src kinase associated phosphoprotein 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOX10 SRY (sex determining region Y)-box 10
SOX3 SRY (sex determining region Y)-box 3
SPHK2 sphingosine kinase 2
SRD5A3 steroid 5 alpha-reductase 3
SSX1 synovial sarcoma, X breakpoint 1
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
STRA6 stimulated by retinoic acid 6
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TM4SF1 transmembrane 4 L six family member 1
TRIM16 tripartite motif containing 16
TRPV6 transient receptor potential cation channel, subfamily V, member 6
UBQLN4 ubiquilin 4
USP2 ubiquitin specific peptidase 2
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
WSCD1 WSC domain containing 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZFP36L2 ZFP36 ring finger protein-like 2
ZFPL1 zinc finger protein-like 1
ZNF137P zinc finger protein 137, pseudogene
ZNF362 zinc finger protein 362
ZNF484 zinc finger protein 484
ZNF652 zinc finger protein 652
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ANKRD40 ankyrin repeat domain 40
ARC activity-regulated cytoskeleton-associated protein
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPHD1 aspartate beta-hydroxylase domain containing 1
BAGE B melanoma antigen
C14ORF79 chromosome 14 open reading frame 79
CCDC176 coiled-coil domain containing 176
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDK20 cyclin-dependent kinase 20
CDK3 cyclin-dependent kinase 3
CDR2L cerebellar degeneration-related protein 2-like
CIC capicua transcriptional repressor
CIDEC cell death-inducing DFFA-like effector c
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CPPED1 calcineurin-like phosphoesterase domain containing 1
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DGAT1 diacylglycerol O-acyltransferase 1
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
EHMT1 euchromatic histone-lysine N-methyltransferase 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM198B family with sequence similarity 198, member B
FBXO22 F-box protein 22
GALK1 galactokinase 1
GK3P glycerol kinase 3 pseudogene
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GSTCD glutathione S-transferase, C-terminal domain containing
HDAC11 histone deacetylase 11
HIST1H4D histone cluster 1, H4d
ICK intestinal cell (MAK-like) kinase
IFT140 intraflagellar transport 140
INPP5J inositol polyphosphate-5-phosphatase J
IPO8 importin 8
ISG20 interferon stimulated exonuclease gene 20kDa
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KIZ kizuna centrosomal protein
KLHL21 kelch-like family member 21
KLHL25 kelch-like family member 25
KLHL36 kelch-like family member 36
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LHX6 LIM homeobox 6
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAST3 microtubule associated serine/threonine kinase 3
MCOLN1 mucolipin 1
MFAP2 microfibrillar-associated protein 2
MSX1 msh homeobox 1
MYO19 myosin XIX
NABP2 nucleic acid binding protein 2
NDE1 nudE neurodevelopment protein 1
NPM3 nucleophosmin/nucleoplasmin 3
NPTX1 neuronal pentraxin I
OASL 2'-5'-oligoadenylate synthetase-like
OLFML3 olfactomedin-like 3
OTUD3 OTU deubiquitinase 3
OXTR oxytocin receptor
PCDHB8 protocadherin beta 8
PECR peroxisomal trans-2-enoyl-CoA reductase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PNPLA6 patatin-like phospholipase domain containing 6
PROS1 protein S (alpha)
PRPH peripherin
PRSS8 protease, serine, 8
PTDSS2 phosphatidylserine synthase 2
PTGES2 prostaglandin E synthase 2
PTK6 protein tyrosine kinase 6
PYGB phosphorylase, glycogen; brain
RAB30 RAB30, member RAS oncogene family
RAB5C RAB5C, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RNF167 ring finger protein 167
SCUBE2 signal peptide, CUB domain, EGF-like 2
SETD1A SET domain containing 1A
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SPON2 spondin 2, extracellular matrix protein
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TBX19 T-box 19
TFF2 trefoil factor 2
TLN1 talin 1
TMEM159 transmembrane protein 159
TMEM209 transmembrane protein 209
TRAPPC13 trafficking protein particle complex 13
TTC30A tetratricopeptide repeat domain 30A
TTLL1 tubulin tyrosine ligase-like family member 1
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
WLS wntless Wnt ligand secretion mediator
ZDHHC14 zinc finger, DHHC-type containing 14
ZMAT5 zinc finger, matrin-type 5
ZNF10 zinc finger protein 10
ZNF124 zinc finger protein 124
ZNF205 zinc finger protein 205
ZNF623 zinc finger protein 623
ZNF639 zinc finger protein 639
ZNF770 zinc finger protein 770
ZNF816 zinc finger protein 816