L-methionine sulfoximine-2470 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the L-methionine sulfoximine-2470 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADARB1 adenosine deaminase, RNA-specific, B1
ADORA1 adenosine A1 receptor
AMN amnion associated transmembrane protein
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARMC4 armadillo repeat containing 4
ATAT1 alpha tubulin acetyltransferase 1
BIN1 bridging integrator 1
BIRC7 baculoviral IAP repeat containing 7
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CAV2 caveolin 2
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CD6 CD6 molecule
CDC42 cell division cycle 42
CLMN calmin (calponin-like, transmembrane)
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CTSF cathepsin F
DCAF4 DDB1 and CUL4 associated factor 4
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
ESR1 estrogen receptor 1
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FSCN3 fascin actin-bundling protein 3, testicular
GFER growth factor, augmenter of liver regeneration
GFOD2 glucose-fructose oxidoreductase domain containing 2
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPR153 G protein-coupled receptor 153
GPR22 G protein-coupled receptor 22
GRIK5 glutamate receptor, ionotropic, kainate 5
H2AFX H2A histone family, member X
HEYL hes-related family bHLH transcription factor with YRPW motif-like
HSDL2 hydroxysteroid dehydrogenase like 2
IGF2-AS IGF2 antisense RNA
IL18RAP interleukin 18 receptor accessory protein
IL27RA interleukin 27 receptor, alpha
IL6ST interleukin 6 signal transducer
ISL1 ISL LIM homeobox 1
KIF1A kinesin family member 1A
KLF12 Kruppel-like factor 12
KRT18 keratin 18, type I
LIG3 ligase III, DNA, ATP-dependent
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
MAPK8 mitogen-activated protein kinase 8
MAU2 MAU2 sister chromatid cohesion factor
MMP3 matrix metallopeptidase 3
MUC3A mucin 3A, cell surface associated
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
NEBL nebulette
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NOV nephroblastoma overexpressed
NXPH4 neurexophilin 4
OLFML2B olfactomedin-like 2B
OMG oligodendrocyte myelin glycoprotein
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PAIP2B poly(A) binding protein interacting protein 2B
PCDH11X protocadherin 11 X-linked
PCDHGB5 protocadherin gamma subfamily B, 5
PDLIM5 PDZ and LIM domain 5
PER3 period circadian clock 3
PKLR pyruvate kinase, liver and RBC
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLSCR3 phospholipid scramblase 3
PMP22 peripheral myelin protein 22
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PQBP1 polyglutamine binding protein 1
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
RAB6B RAB6B, member RAS oncogene family
RHOBTB3 Rho-related BTB domain containing 3
RNF40 ring finger protein 40, E3 ubiquitin protein ligase
RPL35A ribosomal protein L35a
S100A11 S100 calcium binding protein A11
SBNO2 strawberry notch homolog 2 (Drosophila)
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SIRPA signal-regulatory protein alpha
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SLN sarcolipin
SNX13 sorting nexin 13
SOX4 SRY (sex determining region Y)-box 4
SSX3 synovial sarcoma, X breakpoint 3
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TACR1 tachykinin receptor 1
TBX2 T-box 2
TEF thyrotrophic embryonic factor
TKTL1 transketolase-like 1
TMOD1 tropomodulin 1
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TPH1 tryptophan hydroxylase 1
TRAF4 TNF receptor-associated factor 4
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TUBG2 tubulin, gamma 2
ULBP2 UL16 binding protein 2
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
ZER1 zyg-11 related, cell cycle regulator

decreased expression

Symbol Name
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ABHD17B abhydrolase domain containing 17B
ADAM15 ADAM metallopeptidase domain 15
ADAM23 ADAM metallopeptidase domain 23
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AMDHD2 amidohydrolase domain containing 2
ARRB1 arrestin, beta 1
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
BTBD18 BTB (POZ) domain containing 18
C22ORF29 chromosome 22 open reading frame 29
CCDC186 coiled-coil domain containing 186
CD3D CD3d molecule, delta (CD3-TCR complex)
CEP295 centrosomal protein 295kDa
CHMP7 charged multivesicular body protein 7
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3
CNTLN centlein, centrosomal protein
CNTN1 contactin 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEAF1 DEAF1 transcription factor
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DOC2A double C2-like domains, alpha
ELP6 elongator acetyltransferase complex subunit 6
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM222B family with sequence similarity 222, member B
FBXO31 F-box protein 31
FKBP5 FK506 binding protein 5
FLT4 fms-related tyrosine kinase 4
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GIPC1 GIPC PDZ domain containing family, member 1
GNL1 guanine nucleotide binding protein-like 1
GPR27 G protein-coupled receptor 27
GRIP2 glutamate receptor interacting protein 2
GSTA4 glutathione S-transferase alpha 4
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HAMP hepcidin antimicrobial peptide
HOXA5 homeobox A5
HPSE heparanase
IFT46 intraflagellar transport 46
IL12RB1 interleukin 12 receptor, beta 1
IL22 interleukin 22
IL3RA interleukin 3 receptor, alpha (low affinity)
INA internexin neuronal intermediate filament protein, alpha
INO80D INO80 complex subunit D
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LATS1 large tumor suppressor kinase 1
LTBP3 latent transforming growth factor beta binding protein 3
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MDM4 MDM4, p53 regulator
NRBP1 nuclear receptor binding protein 1
NSD1 nuclear receptor binding SET domain protein 1
NSUN6 NOP2/Sun domain family, member 6
NT5DC3 5'-nucleotidase domain containing 3
NXPE3 neurexophilin and PC-esterase domain family, member 3
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PARP16 poly (ADP-ribose) polymerase family, member 16
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma
PDZD7 PDZ domain containing 7
PEX26 peroxisomal biogenesis factor 26
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PHC1 polyhomeotic homolog 1 (Drosophila)
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLCD1 phospholipase C, delta 1
PROCR protein C receptor, endothelial
PRRC1 proline-rich coiled-coil 1
PTGES2 prostaglandin E synthase 2
QTRT1 queuine tRNA-ribosyltransferase 1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
REC8 REC8 meiotic recombination protein
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RWDD2A RWD domain containing 2A
SCUBE3 signal peptide, CUB domain, EGF-like 3
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SGPP1 sphingosine-1-phosphate phosphatase 1
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC22A14 solute carrier family 22, member 14
SLC35F6 solute carrier family 35, member F6
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SOX12 SRY (sex determining region Y)-box 12
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STX11 syntaxin 11
TBC1D19 TBC1 domain family, member 19
THEM6 thioesterase superfamily member 6
TICAM1 toll-like receptor adaptor molecule 1
TMOD3 tropomodulin 3 (ubiquitous)
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TPST1 tyrosylprotein sulfotransferase 1
TRIM25 tripartite motif containing 25
TTPAL tocopherol (alpha) transfer protein-like
TUBA4B tubulin, alpha 4b
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
ZC3H3 zinc finger CCCH-type containing 3
ZNF215 zinc finger protein 215