L-Proline Gene Set

Dataset DrugBank Drug Targets
Category physical interactions
Type drug
Description Pyrrolidine in which the pro-S hydrogen at position 2 is substituted by a carboxylic acid group. L-Proline is the only one of the twenty DNA-encoded amino acids which has a secondary amino group alpha to the carboxyl group. It is an essential component of collagen and is important for proper functioning of joints and tendons. It also helps maintain and strengthen heart muscles. (Chemical Entities of Biological Interest Ontology, CHEBI_17203)
External Link http://www.drugbank.ca/drugs/DB00172
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Genes

22 interacting proteins for the L-Proline drug from the curated DrugBank Drug Targets dataset.

Symbol Name
EPRS glutamyl-prolyl-tRNA synthetase
L3HYPDH L-3-hydroxyproline dehydratase (trans-)
P3H1 prolyl 3-hydroxylase 1
P3H2 prolyl 3-hydroxylase 2
P3H3 prolyl 3-hydroxylase 3
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PARS2 prolyl-tRNA synthetase 2, mitochondrial (putative)
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPIF peptidylprolyl isomerase F
PPIG peptidylprolyl isomerase G (cyclophilin G)
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRODH proline dehydrogenase (oxidase) 1
PROSC proline synthetase co-transcribed homolog (bacterial)
PYCR1 pyrroline-5-carboxylate reductase 1
PYCR2 pyrroline-5-carboxylate reductase family, member 2
PYCRL pyrroline-5-carboxylate reductase-like
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7